Scribd Logo
Upload

Welcome to Scribd!

  • Pathway

    Uploaded by

    Khalid Mahmud Arifin
    28 views2 pages
    The extrinsic and intrinsic pathways are two pathways involved in blood coagulation. The extrinsic pathway involves three steps: 1) release of tissue factor from traumatized tissue, 2) activation of factor X by the tissue factor complex, and 3) formation of a prothrombin activator complex from activated factor X. The intrinsic pathway involves five steps: 1) activation of factor XII and release of platelet phospholipids upon blood trauma, 2) activation of factor XI by activated factor XII, 3) activation of factor IX, 4) activation of factor X, and 5) formation of a prothrombin activator complex from activated factor X.

    Original Description:

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The extrinsic and intrinsic pathways are two pathways involved in blood coagulation. The extrinsic pathway involves three steps: 1) release of tissue factor from traumatized tissue, 2) activation of factor X by the tissue factor complex, and 3) formation of a prothrombin activator complex from activated factor X. The intrinsic pathway involves five steps: 1) activation of factor XII and release of platelet phospholipids upon blood trauma, 2) activation of factor XI by activated factor XII, 3) activation of factor IX, 4) activation of factor X, and 5) formation of a prothrombin activator complex from activated factor X.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    28 views2 pages

    Pathway

    Uploaded by

    Khalid Mahmud Arifin
    The extrinsic and intrinsic pathways are two pathways involved in blood coagulation. The extrinsic pathway involves three steps: 1) release of tissue factor from traumatized tissue, 2) activation of factor X by the tissue factor complex, and 3) formation of a prothrombin activator complex from activated factor X. The intrinsic pathway involves five steps: 1) activation of factor XII and release of platelet phospholipids upon blood trauma, 2) activation of factor XI by activated factor XII, 3) activation of factor IX, 4) activation of factor X, and 5) formation of a prothrombin activator complex from activated factor X.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Extrinsic pathway occurs according to the three

    basic steps:
    1.Release of tissue factor: Traumatized tissue
    releases tissue factor or tissue thromboplastin,
    which includes specially phospholipids &
    lipoprotein complex, that functions mainly as a
    proteolytic enzymes.
    2.Activation of factor X: The lipoprotein complex
    of tissue factor complexes with coagulation factor
    and in the presence of ca+2, acts enzymatically on
    factor X to form activated factor X.
    3.Effect of activated factor X to form prothrombin
    activator: The activated factor X combines with
    tissue phospholipids of tissue factor or with
    additional phospholipids released from platelets as
    well as with factor to form the complex of
    prothrombin activator.

    Intrinsic pathway occurs according to the five


    basic steps:
    1.Activation of factor XII and release of platelet
    phospholipid: Trauma to the blood or exposure of
    the blood to vascular wall collagen alters two
    important clotting factor in the blood.They are
    factor XII & the platelets.When factor XII is
    disturbed by coming into contact with collagen or
    with a wettable surface such as glass, it takes on a
    new cofiguration that converts it into a proteolytic
    enzyme called XIIa. The blood trauma also
    damages the platelets because of adherence to
    either collagen or a wettable surface and this
    releases platelet phospholipids that contains the
    lipoprotein called platelet factor 3,which also plays
    a role in clotting reaction.
    2.Activation of factor XI: The activated factor XII
    acts enzymatically on factor XI to activate this.
    This reaction also requires HMW kininogen and a
    accelerator, called prekallikrein.
    3.Activation of factor IX: The activated factor XI
    acts enzymatically on factor IX to activate this in
    presence of Ca+2.
    4.Activation of factor X: The activated factor IX,
    acts on factor X in concert with factor III, platelet
    phospholipids and factor III.
    5.Activation of activated factor X to form
    prothrombin activator: Activated factor X
    combines with factor , platelet phospholipids &
    factor III to form the complex called prothrombin
    activator.

    You might also like