Reno Jun M.

Nagasan , BSN-3J , Group 33 University of San Carlos, Cebu City

Name of Drug
Indications, Route, &
(Generic & Brand Classifications Mechanism of Action Contraindications Side & Adverse Effects Nursing Responsibilities
Dosage
Names)
Undergoes intracellular Breast-feeding, >To treat systemic CNS: Ataxia, dizziness,  If pt has adverse CNS
Metronidazole Antibiotic chemical reduction hypersensitivity to anaerobic infections encephalopathy, fever, reactions, such as
(Brand Name: Amebicide during anaerobic metronidazole or its caused by Bacteroides headache, light- seizures or peripheral
Anerobizol) Antiprotozoal metabolism. After components, fragilis, Clostidium headedness, peripheral neuropathy, tell
metronidazole is trichomoniasis during difficile, Clostridium neuropathy, seizures (high prescriber and stop drug
reduced, it damages first trimester of perfingens, Eubacterium, doses) immediately.
DNA’s helical structure pregnancy Fusobacterium, EENT: Dry mouth,  Monitor pt with severe
and breaks its strands, Peptococcus, lacrimation (topical form), liver disease because
which inhibits bacterial Peptostreptococcus, and metallic taste, pharyngitis slowed metronidazole
nucleic acid synthesis Veillonella sp. GI: Abdominal cramps or metabolism may cause
and causes cell death, Capsules, Tablets pain, anorexia, diarrhea, drug to accumulate in the
Children. 7.5 mg/kg q 6hr nausea, pancreatitis, body and increase the
or 10 mg/kg q 8 hr vomiting risk of adverse effects.
GU: Darkened urine,  If skin irritation occurs,
>To treat amebiasis vaginal candidiasis (oral, apply topical gel less
(Entamoeba histolytica) parenteral, and topical frequently or discontinue
Capsules, Tablets forms); burning or irritation it, as ordered.
Children. 11.6 to 16/7 of sexual partener’s penis,  Monitor CBC and culture
mg/kg t.i.d. for 10 days candidal cervicitis or and sensitivity test if
vaginitis, dysuria, urinary therapy lasts longer than
frequency, vulvitis (vaginal 10 days or if second
form) course of treatment is
HEME: Leukopenia needed
MS: Back pain  Give IV drug by slow
SKIN: burning sensation, infusion over 1 hr; don’t
stinging sensation, dry skin give by direct IN injection
(topical form); erythema,
pruritus, rash, urticaria
(oral and parenteral forms)
OTHER: injection site
edema, pain, or,
tenderness.
Reno Jun M. Nagasan , BSN-3J , Group 33 University of San Carlos, Cebu City