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PATHOPHYSIOLOGY OF TETANUS

Clostridium tetani

Enter damaged
tissue

Production of toxins

TETANOSPASMIN TETANOLYSIN

Peripheral nerves/
bloodstream

CNS

Binds irreversely
to receptor sites

Production of
Blocks neurotransmission
symptoms

Loss of control of Disinhibition of


adrenal autonomic neurons
catecholamine

Autonomic instability Hypersympathetic


state

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