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1bfecebff00cee68ff874effc12cbfe91a7fb007fe21bfecebffcee6beffa2803e00ff874effc12cbfe
91a7fb007fe21bfecebffcee68ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee6beff00a2803
e00ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee68ff874effc12cbfe91a7fb007fe21bfece
bffcee6beffa2803e00ff874effc12cbfe91a7fb007fe21bfecebffcee68ff00874eff00c12cbfe91a7
fb007fe21bfecebff00cee6beff00a2803e00ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee6
8ff874effc12cbfe91a7fb007fe21bfecebffcee6beffa2803e00ff874effc12cbfe91a7fb007fe21bf
ecebffcee68ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee6beff00a2803e00ff00874eff00
c12cbfe91a7fb007fe21bfecebff00cee68ff874effc12cbfe91a7fb007fe21bfecebffcee6beffa280
3e00ff874effc12cbfe91a7fb007fe21bfecebffcee68ff00874eff00c12cbfe91a7fb007fe21bfeceb
ff00cee6beff00a2803e00ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee68ff874effc12cbf
e91a7fb007fe21bfecebffcee6beffa2803e00ff874effc12cbfe91a7fb007fe21bfecebffcee68ff00
874eff00c12cbfe91a7fb007fe21bfecebff00cee6beff00a2803e00ff00874eff00c12cbfe91a7fb00
7fe21bfecebff00cee68ff874effc12cbfe91a7fb007fe21bfecebffcee6beffa2803e00ff874effc12
cbfe91a7fb007fe21bfecebffcee68ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee6beff00a
2803e00ff00874eff00c12cbfe91a7fb007fe21bfecebff00cee68ff874effc12cbfe91a7fb007fe21b
fecebffcee6beffa28039ff09f84fc2be02f0af867c0be05f0cf87fc17e09f05f87f46f09f83bc1de13
d1b4ef0e7857c27e15f0e69d6da3f87bc33e19f0f68f6d67a4683e1fd0b48b3b3d2f46d1b4bb3b5d3b4
bd3ad6dac6c6da0b6822897a0a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a2
a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00fffd9
}}\par}{\phpg\posx2678\pvpg\posy2165\absw7471\absh1487 \f10 \fs15 \cf0 \f10
\fs15 \cf0 tambahan.
\par}{\phpg\posx2678\pvpg\posy2165\absw7471\absh1487 \sl-292 \f10 \fs15 \cf0 \fi679
Penggunaan bahan pemanis aspartam dalam formulasi tablet{\i effervescent}
dimaksudkan
\par}{\phpg\posx2678\pvpg\posy2165\absw7471\absh1487 \sl-292 \f10 \fs15 \cf0 untuk
menutupi rasa tablet yang kurang baik dan membuat produk menjadi lebih menarik
sehingga
\par}{\phpg\posx2678\pvpg\posy2165\absw7471\absh1487 \sl-292 \f10 \fs15 \cf0 akan
diperoleh rasa manis tanpa rasa pahit atau{\i metalic}{\i aftertaste} (Pulungan,
2004). Penelitian ini
\par}{\phpg\posx2678\pvpg\posy2165\absw7471\absh1487 \sl-290 \f10 \fs15 \cf0
bertujuan untuk mendapatkan kadar pemanis aspartam yang menghasilkan tablet
effervescent
\par}{\phpg\posx2678\pvpg\posy2165\absw7471\absh1487 \sl-295 \f10 \fs15 \cf0 dengan
kualitas fisik yang baik serta rasa yang menyenangkan. \par
}
\cf0 METODE PENELITIAN
{\fs15 Bahan }
\fi679 {\b0 \fs15 Bahan-bahan}{\b0 \fs15 yang}{\b0 \fs15 digunakan}{\b0 \fs15
pada}{\b0 \fs15 percobaan}{\b0 \fs15 ini}{\b0 \fs15 yaitu}{\b0 \fs15
simplisia}{\b0 \fs15 kering}{\b0 \fs15 akar}{\b0 \fs15 Ginseng }
{\b0 \fs15 Jawa}{\b0 \fs15 (}{\b0\i \fs15 Talinum}{\b0\i \fs15 paniculatum}
{\b0 \fs15 )}{\b0 \fs15 dari}{\b0 \fs15 daerah}{\b0 \fs15 Kaliurang-Yogyakarta,}
{\b0 \fs15 bahan}{\b0 \fs15 lain}{\b0 \fs15 yang}{\b0 \fs15 digunakan}{\b0
\fs15 adalah }
{\b0 \fs15 asam}{\b0 \fs15 sitrat,}{\b0 \fs15 asam}{\b0 \fs15 tartrat,}{\b0
\fs15 natrium}{\b0 \fs15 bikarbonat,}{\b0 \fs15 aspartam,}{\b0 \fs15 manitol,}
{\b0 \fs15 PEG}{\b0 \fs15 4000.}{\b0 \fs15 Kecuali}{\b0 \fs15 dinyatakan}
{\b0 \fs15 lain }
{\b0 \fs15 bahan}{\b0 \fs15 yang}{\b0 \fs15 digunakan}{\b0 \fs15 memiliki}
{\b0 \fs15 kualitas}{\b0 \fs15 farmasetis. }
{\fs15 Alat }
\fi679 {\b0 \fs15 Alat}{\b0 \fs15 yang}{\b0 \fs15 digunakan}{\b0 \fs15 pada}
{\b0 \fs15 penelitian}{\b0 \fs15 ini}{\b0 \fs15 adalah}{\b0 \fs15 panci}
{\b0 \fs15 infusa,}{\b0\i \fs15 Spray}{\b0\i \fs15 Drying}{\b0 \fs15 (}
{\b0\i \fs15 Buchi}{\b0\i \fs15 Mini }
{\b0\i \fs15 Spray}{\b0\i \fs15 Dryer}{\b0 \fs15 B-290),}{\b0 \fs15 neraca}
{\b0 \fs15 elektrik}{\b0 \fs15 (}{\b0\i \fs15 Metler}{\b0\i \fs15 Toledo}{\b0
\fs15 type}{\b0 \fs15 PL303),}{\b0 \fs15 seperangkat}{\b0 \fs15 alat}
{\b0 \fs15 gelas}{\b0 \fs15 (}{\b0\i \fs15 pyrex}{\b0 \fs15 ), }
{\b0 \fs15 oven}{\b0 \fs15 (Memert),}{\b0 \fs15 mesin}{\b0 \fs15 tablet}
{\b0\i \fs15 single}{\b0\i \fs15 punch}{\b0 \fs15 (}{\b0\i \fs15 Korch}{\b0
\fs15 type}{\b0 \fs15 EK}{\b0 \fs15 O),}{\b0\i \fs15 Hardness}{\b0\i \fs15
Tester}{\b0 \fs15 (}{\b0\i \fs15 Vanguard}{\b0 \fs15 type}{\b0 \fs15 YD- }
{\b0 \fs15 2),}{\b0\i \fs15 Friability}{\b0\i \fs15 Tester}{\b0 \fs15 (}
{\b0\i \fs15 Erweka}{\b0 \fs15 type}{\b0 \fs15 T-200),}{\b0 \fs15 alat}{\b0
\fs15 penghisap}{\b0 \fs15 debu}{\b0 \fs15 (}{\b0\i \fs15 lux}{\b0
\fs15 ). }\par
}
\cf0 Preparasi Akar Ginseng Jawa
{\b0 Bagian}{\b0 akar}{\b0 ginseng}{\b0 jawa}{\b0 yang}{\b0 telah}{\b0
dikeringkan,}{\b0 dihaluskan}{\b0 dengan}{\b0\i blender}{\b0 kemudian}{\b0
disari }
{\b0 menggunakan}{\b0 cara}{\b0 infundasi.}{\b0 Ekstrak}{\b0 cair}{\b0
yang}{\b0 diperoleh}{\b0 dikeringkan}{\b0 menggunakan}{\b0 alat}{\b0 Spry
}
{\b0 Drying}{\b0 sehingga}{\b0 dihasilkan}{\b0 serbuk}{\b0 ekstrak}{\b0
kering. }
Pembuatan Tablet{\i effervescent} ekstrak ginseng jawa
{\b0 Formulasi}{\b0 tablet}{\b0 effervescent}{\b0 ekstrak}{\b0 ginseng}{\b0
jawa}{\b0 dibuat}{\b0 sesuai}{\b0 dengan}{\b0 formula}{\b0 yang}{\b0
ditunjukkan }
{\b0 pada}{\b0 tabel}{\b0 1.}{\b0 Serbuk}{\b0 kering}{\b0 ekstrak}{\b0
ginseng}{\b0 jawa}{\b0 dicampur}{\b0 dengan}{\b0 manitol}{\b0 kemudian}{\b0
berturut-turut }
{\b0 ditambahkan}{\b0 asam}{\b0 sitrat,}{\b0 asam}{\b0 tartrat}{\b0 dan}{\b0
natrium}{\b0 bikarbonat.}{\b0 Campuran}{\b0 diaduk}{\b0 sampai}{\b0 homogen }
{\b0 kemudian}{\b0 dikeringkan}{\b0 dalam}{\b0 oven}{\b0 pada}{\b0 suhu}
{\b0 70�C}{\b0 selama}{\b0 45}{\b0 menit.}{\b0 Campuran}{\b0 diayak}
{\b0 dengan }
{\b0 ukuran}{\b0 mesh}{\b0 40,}{\b0 selanjutnya}{\b0 di}{\b0 tambahkan}
{\b0 PEG}{\b0 4000}{\b0 dan}{\b0 pemanis}{\b0 aspartam,}{\b0 campuran}
{\b0 diaduk }
{\b0 sampai}{\b0 homogen}{\b0 dan}{\b0 dicetak}{\b0 menggunakan}{\b0 mesin}
{\b0 cetak}{\b0 tablet}{\b0\i single}{\b0\i punch}{\b0 (}{\b0\i Korch}{\b0
type}{\b0 EK}{\b0 O). }
\fi1334 Tabel 1. Formula Tablet Effervescent Ekstrak Ginseng Jawa \par
}
{\phpg\posx2678\pvpg\posy11664\absw1430\absh2077 \f10 \fs15 \cf0 \fi523 \f10
\fs15 \cf0 Bahan (mg)
\par}{\phpg\posx2678\pvpg\posy11664\absw1430\absh2077 \sl-153 \par\f10 \fs15 \cf0
Ekstrak kering
\par}{\phpg\posx2678\pvpg\posy11664\absw1430\absh2077 \sl-302 \f10 \fs15 \cf0 Asam
sitrat
\par}{\phpg\posx2678\pvpg\posy11664\absw1430\absh2077 \sl-302 \f10 \fs15 \cf0 Asam
tartrat
Natrium bikarbonat
\par}{\phpg\posx2678\pvpg\posy11664\absw1430\absh2077 \sl-300 \f10 \fs15 \cf0 PEG
4000
Aspartam
Manitol \par
}
Formula I
\par}{\phpg\posx4814\pvpg\posy11369\absw994\absh2343 \sl-300 \f10 \fs15 \cf0 3%
aspartam
\par}{\phpg\posx4814\pvpg\posy11369\absw994\absh2343 \sl-302 \f10 \fs15 \cf0 150
\par
}
Formula II
\par}{\phpg\posx6679\pvpg\posy11369\absw1136\absh2343 \sl-300 \f10 \fs15 \cf0 3,5%
aspartam
\par
}
Formula III
aspartam
\par
}
44 \par
}
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10101010101010101010101010101010101010101010101010101010101010101010101010101010101
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1010101010101010101010101010101010101010101010101010101010101010101ffc0001108031802
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a0028a28a0028a28a0028a28a0028a28a0028a28a0028af883c59e3eff829259f8abc4d67e05fd943f6
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e3dd23c27e20d53485b3bed67c33a5f8ebc69a7685a8cf73a5d8f8b3c476d6b16b179f6fd0014514500
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51450014514500145145001451450014514500145145001451450014514500145145001451450014514
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1451450014514500145145001451450014514500145145001451450015e7ff0014be25f873e0ff00813
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1e59fb3affd139fdbff00ff00153bff00054dff00e837a3fe1e59fb3aff00d139fdbfff00f153bff054
dffe837afbfe8a00f803fe1e59fb3aff00d139fdbfff00f153bff054dffe837ae83c27ff000506f80de
34f157867c1da3f807f6dfb3d5fc59e20d1bc33a5de78b3fe0993ff000524f017856d751d7751b6d2ec
6e7c4de3af1d7eca1e1cf04f82fc3f05cdd452eb3e2cf18f88742f0af8734e5b9d63c43ace97a459de5
f41f6fd1400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
14514005145140051451400514514005145140051451400514514005145140051451400514514005145
14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
14514005145140051451400514514005145140051451400514514005145140051451400514514005145
14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
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14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
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05145140051451400514514005145140051451400514514005145140051451400514514005145140051
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05145140051451400514514005145140051451400514514005145140051451400514514005145140051
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40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
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05145140051451400514514005145140051451400514514005145140051451400514514005145140051
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40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
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05145140051451400514514005145140051451400514514005145140051451400514514005145140051
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51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
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14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
14514005145140051451400514514005145140051451400514514005145140051451400514514005145
14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
14514005145140051451400514514005145140051451400514514005145140051451400514514005145
14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
14514005145140051451400514514005145140051451400514514005145140051451400514514005145
14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451400
51451400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514514
00514514005145140051451400514514005145140051451400514514005145140051451400514514005
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14005145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140051
45140051451400514514005145140051451400514514005145140051451400514514005145140051451
40051451400514514005145140051451400514514005145140051451400514514005145140051451401
ffd9
}}\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh2539 \b \f10 \fs15 \cf0 \b
\f10 \fs15 \cf0 Uji Kualitas Tablet Effervescent
\fi679 Uji sifat fisik granul{\b0 .}{\b0 Sebelum}{\b0 granul}{\b0
dicetak,}{\b0 terlebih}{\b0 dahulu}{\b0 dilakukan}{\b0 uji}{\b0 sifat}
{\b0 fisik }
{\b0 granul}{\b0 yang}{\b0 meliputi}{\b0 kecepatan}{\b0 alir,}{\b0 sudut}{\b0
diam,}{\b0 pengetapan,}{\b0 dan}{\b0 densitas}{\b0 massa }
\fi679 Kecepatan alir.{\b0 Granul}{\b0 seberat}{\b0 100}{\b0 gram}{\b0
dituang}{\b0 perlahan-lahan}{\b0 kedalam}{\b0 corong}{\b0 yang }
{\b0 tertutup}{\b0 bagian}{\b0 bawahnya}{\b0 lewat}{\b0 tepi}{\b0
corong.}{\b0 Buka}{\b0 tutup}{\b0 corong}{\b0 secara}{\b0 perlahan-lahan}
{\b0 biarkan }
{\b0 granul}{\b0 mengalir}{\b0 keluar.}{\b0 Dicatat}{\b0 waktu}{\b0 yang}
{\b0 diperlukan}{\b0 (detik)}{\b0 dengan}{\b0\i stop}{\b0\i watch}{\b0
sampai}{\b0 semua }
{\b0 granul}{\b0 melewati}{\b0 corong}{\b0 (Parrott,}{\b0 1971).}{\b0
Kecepatan}{\b0 alir}{\b0 granul}{\b0 yang}{\b0 baik}{\b0 adalah}{\b0
lebih}{\b0 dari}{\b0 10 }
{\b0 gram/detik}{\b0 (Carstensen}{\b0 dan}{\b0 Chan,}{\b0 1977). }
\fi679 Sudut diam.{\b0 Granul}{\b0 seberat}{\b0 100}{\b0 gram}{\b0
dituang}{\b0 secara}{\b0 perlahan}{\b0 melalui}{\b0 dinding}{\b0
corong. }
{\b0 Buka}{\b0 penutup}{\b0 corong}{\b0 dan}{\b0 biarkan}{\b0 granul}{\b0
mengalir.}{\b0 Ukur}{\b0 tinggi}{\b0 kerucut}{\b0 dan}{\b0 jari-jari}{\b0
kerucut}{\b0 yang }\par
}
terbentuk. Sudut diam dihitung berdasarkan rumus berikut : Tg{\f20
{\field{\*\fldinst SYMBOL 97 \\f Symbol }}}= \par
}
{\phpg\posx7718\pvpg\posy5083\absw146\absh508 \i \f20 \fs20 \cf0 \i \f20 \fs20 \cf0
h
\par}{\phpg\posx7718\pvpg\posy5083\absw146\absh508 \sl-314 \i \f20 \fs20 \cf0 r
\par
}
\f10 \fs15 \cf0 Pengetapan.{\b0 Granul}{\b0 dituang}{\b0 pelan-pelan}{\b0
kedalam}{\b0 gelas}{\b0 ukur}{\b0 sampai}{\b0 volume}{\b0 100}{\b0 ml}{\b0
dan }
{\b0 dicatat}{\b0 sebagai}{\b0 Vo.}{\b0 Gelas}{\b0 ukur}{\b0 dipasang}{\b0
pada}{\b0 alat}{\b0 dan}{\b0 motor}{\b0 dihidupkan.}{\b0 Catat}{\b0
perubahan}{\b0 volume }
{\b0 pada}{\b0 tap}{\b0 ke}{\b0 5,}{\b0 10,}{\b0 15}{\b0 dan}{\b0
seterusnya}{\b0 sampai}{\b0 volume}{\b0 granul}{\b0 konstan}{\b0 dan}{\b0
dicatat}{\b0 sebagai}{\b0 Vt. }
{\b0 Kemudian}{\b0 bobot}{\b0 granul}{\b0 ditimbang.}{\b0 Pengurangan}{\b0
volume}{\b0 granul}{\b0 akibat}{\b0 pengetapan}{\b0 dinyatakan }
{\b0 sebagai}{\b0 harga}{\b0 Tap}{\b0 (%)}{\b0 (Fassihi}{\b0 &}{\b0 Kanfer,}
{\b0 1986). }\par
}
{\phpg\posx2726\pvpg\posy7375\absw423\absh170 \f10 \fs15 \cf0 \f10 \fs15 \cf0 %T
= \par
}
Vo{\i0 \f40 {\f63 \u61485\'3f}}Vt
\par}{\phpg\posx3165\pvpg\posy7162\absw652\absh531 \sl-314 \i \f20 \fs20 \cf0
\fi199 Vo \par
}
x{\i0 100% }\par
}
{\phpg\posx2678\pvpg\posy7838\absw7470\absh697 \b \f10 \fs15 \cf0 \fi679 \b \f10
\fs15 \cf0 Densitas massa.{\b0 Gelas}{\b0 ukur}{\b0 100}{\b0 ml}{\b0
ditimbang,}{\b0 granul}{\b0 dimasukkan}{\b0 kedalam}{\b0 gelas}{\b0
ukur }
\par}{\phpg\posx2678\pvpg\posy7838\absw7470\absh697 \sl-292 \b \f10 \fs15 \cf0 {\b0
hingga}{\b0 volumenya}{\b0 mencapai}{\b0 100}{\b0 ml}{\b0 lewat}{\b0
tepi}{\b0 gelas}{\b0 ukur.}{\b0 Gelas}{\b0 ukur}{\b0 yang}{\b0 sudah}
{\b0 diisi}{\b0 granul }
tersebut}{\b0 kemudian}{\b0 ditimbang.}{\b0 Densitas}{\b0 granul}{\b0
tersebut}{\b0 dihitung}{\b0 dengan}{\b0 rumus}{\b0 berikut. }\par
}
{\phpg\posx2678\pvpg\posy8899\absw266\absh170 \f10 \fs15 \cf0 \f10 \fs15 \cf0 P
= \par
}
{\phpg\posx3035\pvpg\posy8684\absw5350\absh533 \f20 \fs20 \cf0 \f20 \fs20 \cf0 ({\i
bobot}{\i gelas}{\i ukur}{\f40 {\f63 \u61483\'3f}}{\i granul}){\f40 {\f63
\u61485\'3f}}{\i bobot}{\i gelas}{\i ukur}{\i kosong }
{\i volume}{\i gelas}{\i ukur }\par
}
\cf0 Uji Sifat Fisik Tablet.
Untuk}{\b0 mengetahui}{\b0 kualitas}{\b0 tablet}{\b0 yang}{\b0 telah}{\b0
dicetak,}{\b0 maka}{\b0 dilakukan}{\b0 uji}{\b0 sifat}{\b0 fisik}{\b0 tablet}
{\b0 yang }
meliputi,}{\b0 keseragaman}{\b0 bobot,}{\b0 kekerasan,}{\b0 kerapuhan,}{\b0
dan}{\b0 waktu}{\b0 larut. }
\fi679 Keseragaman bobot{\b0 .}{\b0 Dua}{\b0 puluh}{\b0 tablet}{\b0\i
effervescent}{\b0 ditimbang}{\b0 satu}{\b0 persatu}{\b0 dengan }\par
}
{\phpg\posx7046\pvpg\posy10861\absw37\absh87 \f20 \fs6 \cf0 \f20 \fs6 \cf0 _ \par
}
neraca elektrik. Kemudian dihitung harga rata-rata ({\i \f20 \fs11 x}
), Standar Deviasi (SD) dan persen
penyimpangan bobot. Hasil yang diperoleh dibandingkan dengan persyaratan
yang ada dalam
Farmakope Indonesia (Anonim, 1979).
\fi679 {\b Kekerasan.} Sebuah tablet diletakkan pada alat{\i hardness}{\i
tester} ({\i Vanguard} type YD-2)
\par}{\phpg\posx2678\pvpg\posy10882\absw7472\absh2803 \sl-290 \f10 \fs15 \cf0 Alat
ini secara otomatis akan menentukan kekerasan tablet yang kemudian
hasilnya dapat dilihat
\par}{\phpg\posx2678\pvpg\posy10882\absw7472\absh2803 \sl-292 \f10 \fs15 \cf0 dari
angka yang muncul pada alat tersebut. Dilakukan terhadap 10 tablet.
\fi679 {\b Kerapuhan.} Dua puluh tablet dibebas debukan dengan aspirator kemudian
ditimbang lalu
dimasukkan ke{\i friability}{\i tester} ({\i Erweka} type T-200) Alat dihidupkan
dan diputar dengan kecepatan
rpm selama 4 menit. Setelah selesai tablet dikeluarkan dari alat dibebasdebukan dan
ditimbang
\par}{\phpg\posx2678\pvpg\posy10882\absw7472\absh2803 \sl-295 \f10 \fs15 \cf0 lagi.
Dihitung persentase bobot tablet yang berkurang dari bobot tablet mula-mula.
\fi679 {\b Waktu}{\b larut.} Sebuah tablet dimasukkan ke dalam air dengan
volume 200 ml pada suhu \par
}
45 \par
}
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\fs15 \cf0 sekitar 25�C. Waktu dicatat dengan{\i stop}{\i watch} sampai tablet
hancur dan larut semua.
\par}{\phpg\posx2678\pvpg\posy2165\absw7473\absh1487 \sl-292 \f10 \fs15 \cf0 {\b
Uji}{\b Tanggapan}{\b Rasa }
\par}{\phpg\posx2678\pvpg\posy2165\absw7473\absh1487 \sl-292 \f10 \fs15 \cf0 Uji
tanggapan rasa dilakukan dengan memberikan angket pada 20 orang responden
yang telah
meminum tablet tersebut untuk menilai rasa dari tablet{\i effervescent}
yang dibuat. Data yang
diperoleh dianalisis secara deskriptif untuk mengetahui tanggapan responden
terhadap rasa tablet
effervescent ekstrak ginseng jawa. \par
}
\cf0 HASIL DAN PEMBAHASAN
\fi679 {\fs15 Sifat}{\fs15 Fisik}{\fs15 Granul}{\b0 \fs15 .}{\b0 \fs15 Hasil}
{\b0 \fs15 uji}{\b0 \fs15 sifat}{\b0 \fs15 fisik}{\b0 \fs15 granul}{\b0
\fs15 yang}{\b0 \fs15 meliputi}{\b0 \fs15 kecepatan}{\b0 \fs15 alir,}
{\b0 \fs15 sudut}{\b0 \fs15 diam, }
{\b0 \fs15 pengetapan}{\b0 \fs15 dan}{\b0 \fs15 densitas}{\b0 \fs15 massa}
{\b0 \fs15 menunjukkan}{\b0 \fs15 bahwa}{\b0 \fs15 semua}{\b0 \fs15
formula}{\b0 \fs15 memiliki}{\b0 \fs15 sifat}{\b0 \fs15 fisik}{\b0 \fs15
granul }
{\b0 \fs15 yang}{\b0 \fs15 baik.}{\b0 \fs15 Hasil}{\b0 \fs15 uji}{\b0 \fs15
sifat}{\b0 \fs15 fisik}{\b0 \fs15 granul}{\b0 \fs15 ditunjukkan}{\b0 \fs15
pada}{\b0 \fs15 table}{\b0 \fs15 2.}{\b0 \fs15 Kecepatan}{\b0 \fs15 alir}
{\b0 \fs15 granul}{\b0 \fs15 yang}{\b0 \fs15 dibuat }
{\b0 \fs15 berkisar}{\b0 \fs15 antara}{\b0 \fs15 17}{\b0 \fs15 g/det}{\b0 \fs15
sampai}{\b0 \fs15 19}{\b0 \fs15 g/det}{\b0 \fs15 (Tabel}{\b0 \fs15 2).}{\b0
\fs15 Hasil}{\b0 \fs15 yang}{\b0 \fs15 diperoleh}{\b0 \fs15 tersebut}{\b0
\fs15 lebih}{\b0 \fs15 besar}{\b0 \fs15 dari }
{\b0 \fs15 batas}{\b0 \fs15 toleransi}{\b0 \fs15 minimum,}{\b0 \fs15 yaitu}
{\b0 \fs15 10}{\b0 \fs15 g/det,}{\b0 \fs15 sehingga}{\b0 \fs15 diharapkan}
{\b0 \fs15 apabila}{\b0 \fs15 masa}{\b0 \fs15 granul}{\b0 \fs15 tersebut}
{\b0 \fs15 dicetak }
{\b0 \fs15 dengan}{\b0 \fs15 mesin}{\b0 \fs15 pencetak}{\b0 \fs15 tablet}{\b0
\fs15 akan}{\b0 \fs15 dihasilkan}{\b0 \fs15 tablet}{\b0 \fs15 dengan}{\b0 \fs15
keseragaman}{\b0 \fs15 bobot}{\b0 \fs15 yang}{\b0 \fs15 baik. }
\fi679 {\b0 \fs15 Sudut}{\b0 \fs15 diam}{\b0 \fs15 granul}{\b0 \fs15 yang}
{\b0 \fs15 baik}{\b0 \fs15 adalah}{\b0 \fs15 antara}{\b0 \fs15 25-45�}
{\b0 \fs15 (Voigt,1984),}{\b0 \fs15 uji}{\b0 \fs15 ini}{\b0 \fs15
merupakan }
{\b0 \fs15 rangkaian}{\b0 \fs15 dari}{\b0 \fs15 uji}{\b0 \fs15 waktu}{\b0 \fs15
alir}{\b0 \fs15 yang}{\b0 \fs15 bertujuan}{\b0 \fs15 untuk}{\b0 \fs15
mengetahui}{\b0 \fs15 baik}{\b0 \fs15 tidaknya}{\b0 \fs15 kecepatan}{\b0 \fs15
alir}{\b0 \fs15 granul. }
{\b0 \fs15 Semua}{\b0 \fs15 formula}{\b0 \fs15 memenuhi}{\b0 \fs15
persyaratan}{\b0 \fs15 sudut}{\b0 \fs15 diam}{\b0 \fs15 yang}{\b0 \fs15
optimal}{\b0 \fs15 (table}{\b0 \fs15 2).}{\b0 \fs15 Pengetapan }
{\b0 \fs15 menunjukkan}{\b0 \fs15 penurunan}{\b0 \fs15 volume}{\b0 \fs15
granul}{\b0 \fs15 akibat}{\b0 \fs15 hentakan}{\b0 \fs15 dan}{\b0 \fs15
getaran.}{\b0 \fs15 Besar}{\b0 \fs15 kecilnya}{\b0 \fs15 indeks }
{\b0 \fs15 pengetapan}{\b0 \fs15 dipengaruhi}{\b0 \fs15 oleh}{\b0 \fs15
bentuk}{\b0 \fs15 granul,}{\b0 \fs15 kerapatan}{\b0 \fs15 dan}{\b0 \fs15
ukuran}{\b0 \fs15 granul.}{\b0 \fs15 Semakin}{\b0 \fs15 besar}{\b0 \fs15
indeks }
{\b0 \fs15 pengetapan}{\b0 \fs15 mengakibatkan}{\b0 \fs15 sifat}{\b0 \fs15
alir}{\b0 \fs15 yang}{\b0 \fs15 kurang}{\b0 \fs15 baik,}{\b0 \fs15 pada}
{\b0 \fs15 formula}{\b0 \fs15 III}{\b0 \fs15 menunjukkan}{\b0 \fs15
indeks }
{\b0 \fs15 pengetapan}{\b0 \fs15 yang}{\b0 \fs15 paling}{\b0 \fs15 besar}{\b0
\fs15 (tabel}{\b0 \fs15 2)}{\b0 \fs15 sehingga}{\b0 \fs15 berpotensi}{\b0 \fs15
meurunkan}{\b0 \fs15 kecepatan}{\b0 \fs15 alir}{\b0 \fs15 granul. }
\fi679 {\b0 \fs15 Densitas}{\b0 \fs15 massa}{\b0 \fs15 merupakan}{\b0 \fs15
perbandingan}{\b0 \fs15 antara}{\b0 \fs15 bobot}{\b0 \fs15 dan}{\b0 \fs15
volume}{\b0 \fs15 granul.}{\b0 \fs15 Semakin }
{\b0 \fs15 besar}{\b0 \fs15 densitas}{\b0 \fs15 massa}{\b0 \fs15 granul}
{\b0 \fs15 maka}{\b0 \fs15 semakin}{\b0 \fs15 mudah}{\b0 \fs15 granul}
{\b0 \fs15 mengalir.}{\b0 \fs15 Formula}{\b0 \fs15 I}{\b0 \fs15 memiliki}
{\b0 \fs15 densitas }
{\b0 \fs15 yang}{\b0 \fs15 paling}{\b0 \fs15 besar}{\b0 \fs15 dibanding}{\b0
\fs15 dengan}{\b0 \fs15 formula}{\b0 \fs15 lainnya}{\b0 \fs15 yaitu}{\b0 \fs15
0,63}{\b0 \fs15 g/ml}{\b0 \fs15 (tabel}{\b0 \fs15 2). }\par
}
\cf0 Tabel 2. Hasil Uji sifat Fisik Granul Tablet Effervescent Ekstrak Ginseng Jawa
\par
}
\f10 \fs15 \cf0 Sifat Fisik
{\b0 Kecepatan}{\b0 alir}{\b0 (g/dtk) }
{\b0 Sudut}{\b0 diam}{\b0 (�) }
{\b0 Pengetapan}{\b0 (%) }
{\b0 Densitas}{\b0 massa}{\b0 (g/ml) }\par
}
\f10 \fs15 \cf0 Formula I
\fi170 (Aspartam 3%)
{\b0 19,2}{\b0 �}{\b0 1,4 }
{\b0 29,9}{\b0 �}{\b0 0,6 }
{\b0 11,3}{\b0 �}{\b0 0,3 }
{\b0 0,63}{\b0 �}{\b0 0,05 }\par
}
\f10 \fs15 \cf0 Formula II
\fi192 (Aspartam 3,5%)
{\b0 18,4}{\b0 �}{\b0 0,9 }
{\b0 30,4}{\b0 �}{\b0 2,4 }
{\b0 12,5}{\b0 �}{\b0 0,5 }
{\b0 0,51}{\b0 �}{\b0 0,02 }\par
}
\f10 \fs15 \cf0 Formula III
{\b0 17,9}{\b0 �}{\b0 0,6 }
{\b0 32,3}{\b0 �}{\b0 0,3 }
{\b0 14,8}{\b0 �}{\b0 0,8 }
{\b0 0,51}{\b0 �}{\b0 0,00 }\par
}
\f10 \fs15 \cf0 Sifat fisik tablet.{\b0 Pelaksanaan}{\b0 uji}{\b0 sifat}
{\b0 fisik}{\b0 tablet}{\b0\i effervescent}{\b0 seluruhnya}{\b0
dilakukan}{\b0 di }
{\b0 ruang}{\b0 dengan}{\b0 kelembaban}{\b0 relatif}{\b0 40%,}{\b0 hal}
{\b0 tersebut}{\b0 untuk}{\b0 menghindari}{\b0 pengaruh}{\b0 kelembaban }
{\b0 karena}{\b0 sifat}{\b0 dari}{\b0 tablet}{\b0\i effervescent}{\b0
yang}{\b0 dihasilkan}{\b0 sangat}{\b0 higroskopis}{\b0 sehingga}{\b0
dikhawatirkan }
{\b0 dapat}{\b0 berpengaruh}{\b0 pada}{\b0 hasil}{\b0 uji. }
{\b0 Kekerasan}{\b0 tablet}{\b0 effervescent}{\b0 ekstrak}{\b0 ginseng}
{\b0 jawa}{\b0 diperoleh}{\b0 bahwa}{\b0 hasil}{\b0 uji}{\b0
memenuhi }
{\b0 persyaratan}{\b0 mutu}{\b0 kekerasan}{\b0 tablet}{\b0 yang}{\b0
baik,}{\b0 yaitu}{\b0 masuk}{\b0 dalam}{\b0 range}{\b0 4-8}{\b0 kg}{\b0
(Banker}{\b0 dan }
{\b0 Anderson}{\b0\i ,}{\b0 1986)}{\b0 (tabel}{\b0 3).}{\b0 Antara}{\b0
formula}{\b0 I,}{\b0 II}{\b0 dan}{\b0 III,}{\b0 kekerasan}{\b0
tablet}{\b0 tidak}{\b0 menunjukkan }
{\b0 perbedaan}{\b0 yang}{\b0 bermakna}{\b0 setelah}{\b0 di}{\b0
analisis}{\b0 dengan}{\b0 menggunakan}{\b0 Analisis}{\b0 variansi}{\b0
satu}{\b0 arah }
{\b0 (ANOVA)}{\b0 (p<0,05). }
\fi679 {\b0 Kerapuhan}{\b0 tablet}{\b0 juga}{\b0 tidak}{\b0 menunjukkan}{\b0
perbedaan}{\b0 yang}{\b0 bermakna}{\b0 pada}{\b0 tiap}{\b0 formulasi }\par
}
46 \par
}
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45140051451400514514005145140051451400514514005145140051451400514514005145140051451
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ff00fe1b9ff82597ff004b4e8ff8637fda2bfe92c5fb7fff00e1b9ff0082597ff4b4ebeffa2803e00ff
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004b4ebeff00a2803e60fd8bff00643f835fb05fecbff083f647f80165e20b3f853f063c3f7ba3787a5
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8a2800a28a2800a28a2800a28a2800a28a2800a
2800a28a2800a28a2800a28a2800a28a2800a28a2800a28a2803ffd9
\fs15 \cf0 tablet effervescent yang dibuat, namun prosentase kerapuhan
yang dihasilkan tiap formula
memenuhi syarat mutu tablet yang baik yaitu di bawah 1% (Banker
dan Anderson, 1986).
Kerapuhan yang paling kecil diperoleh dari formula III (tabel 3). Kerapuhan
merupakan gambaran
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-292 \f10 \fs15 \cf0 dari
kekuatan ikatan partikel dari bahan-bahan pembentuk tablet, semakin kompak
ikatan antar
penyusun tablet tersebut maka tablet akan semakin tahan terhadap proses
pengikisan. Terdapat
hubungan antara kekerasan tablet dan kerapuhan, yaitu semakin tinggi
kekerasan tablet maka
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-290 \f10 \fs15 \cf0 ikatan
antar partikel penyusun tablet semakin kuat sehingga kerapuhannya akan
semakin kecil.
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-292 \f10 \fs15 \cf0 Begitu
pula sebaliknya.
Hasil uji waktu larut tablet dari semua formula menunjukkan bahwa
waktu yang
dibutuhkan untuk melarut tidak memenuhi pesyaratan mutu tablet yang baik.
Tablet effervescent
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-292 \f10 \fs15 \cf0 yang
baik akan larut dalam waktu 1-2 menit, sedangkan waktu larut tablet
effervescent tablet
ekstrak ginseng jawa adalah 7-8 menit (tabel 3). Factor yang sangat berpengaruh
terhadap waktu
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-292 \f10 \fs15 \cf0 larut
tablet effervescent adalah bahan penghancur berupa sumber asam (asam
tartrat dan asam
sitrat) dan sumber basa (Natrium bikarbonat). Oleh karena itu dalam
proses pencampuran kedua
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-292 \f10 \fs15 \cf0 bahan
ini dilakukan dengan hati-hati sehingga tidak terjadi reaksi dini
yang mengakibatkan
\par}{\phpg\posx2678\pvpg\posy2165\absw7472\absh4200 \sl-189 \par\f10 \fs15 \cf0
terlepasnya CO{\dn006 \f20 \fs11 2}. \par
}
\cf0 Tabel 3. Hasil Uji Sifat Fisik Tablet Effervescent Ekstrak Ginseng Jawa \par
}
{\phpg\posx3227\pvpg\posy7507\absw799\absh170 \b \f10 \fs15 \cf0 \b \f10 \fs15 \cf0
Sifat Fisik \par
}
Kekerasan (kg)
Kerapuhan (%)
\par}{\phpg\posx2678\pvpg\posy8100\absw1430\absh714 \sl-302 \f10 \fs15 \cf0 Waktu
larut (menit) \par
}
\f10 \fs15 \cf0 Formula I
{\b0 9,03}{\b0 �}{\b0 0,99 }
{\b0 0,56}{\b0 �}{\b0 0,17 }
{\b0 7,64}{\b0 �}{\b0 0,20 }\par
}
\f10 \fs15 \cf0 Formula II
\fi192 (Aspartam 3,5%)
{\b0 9,39}{\b0 �}{\b0 0,85 }
{\b0 0,47}{\b0 �}{\b0 0,09 }
{\b0 8,09}{\b0 �}{\b0 0,03 }\par
}
\f10 \fs15 \cf0 Formula III
{\b0 9,64}{\b0 �}{\b0 0,76 }
{\b0 0,41}{\b0 �}{\b0 0,21 }
{\b0 8,42}{\b0 �}{\b0 0,03 }\par
}
{\phpg\posx2678\pvpg\posy9298\absw7469\absh960 \f10 \fs15 \cf0 \fi679 \f10 \fs15
\cf0 Tanggapan responden terhadap tablet effervescent ekstrak ginseng jawa
menunjukkan
dari seluruh responden menerima rasa tablet dan tidak ada perbedaan bermakna
tanggapan
responden terhadap ketiga formula tersebut, namun beberapa saran dan komentar dari
responden
\par}{\phpg\posx2678\pvpg\posy9298\absw7469\absh960 \sl-292 \f10 \fs15 \cf0 agar
tampilan dan warna tablet dibuat lebih menarik. \par
}
{\phpg\posx2678\pvpg\posy10858\absw7469\absh2304 \b \f10 \fs16 \cf0 \b \f10
\fs16 \cf0 KESIMPULAN
\par}{\phpg\posx2678\pvpg\posy10858\absw7469\absh2304 \sl-154 \par\b \f10 \fs16
\cf0 \fi340 {\b0 \fs15 1.}{\b0 \fs15 Penambahan}{\b0 \fs15 pemanis}{\b0
\fs15 aspartam}{\b0 \fs15 terhadap}{\b0 \fs15 tablet}{\b0 \fs15
effervescent}{\b0 \fs15 ekstrak}{\b0 \fs15 ginseng}{\b0 \fs15 jawa }
\fi679 {\b0 \fs15 menghasilkan}{\b0 \fs15 keseragaman,}{\b0 \fs15 kekerasan}
{\b0 \fs15 dan}{\b0 \fs15 kerapuhan}{\b0 \fs15 tablet}{\b0 \fs15 memenuhi}
{\b0 \fs15 persyaratan }
\fi679 {\b0 \fs15 kualitas}{\b0 \fs15 fisik}{\b0 \fs15 tablet}{\b0 \fs15
yang}{\b0 \fs15 baik,}{\b0 \fs15 sedangkan}{\b0 \fs15 waktu}{\b0 \fs15
larutnya}{\b0 \fs15 tidak}{\b0 \fs15 memenuhi}{\b0 \fs15 persyaratan }
\fi679 {\b0 \fs15 kualitas}{\b0 \fs15 fisik}{\b0 \fs15 tablet}{\b0 \fs15 yang}
{\b0 \fs15 baik. }
\fi340 {\b0 \fs15 2.}{\b0 \fs15 Variasi}{\b0 \fs15 pemanis}{\b0 \fs15
aspartam}{\b0 \fs15 3%,}{\b0 \fs15 3,5%}{\b0 \fs15 dan}{\b0 \fs15 4%}
{\b0 \fs15 tidak}{\b0 \fs15 menghasilkan}{\b0 \fs15 perubahan}{\b0 \fs15
sifat}{\b0 \fs15 fisik }
\fi679 {\b0 \fs15 tablet}{\b0 \fs15 effervescent}{\b0 \fs15 ekstrak}{\b0 \fs15
ginseng}{\b0 \fs15 jawa. }
\fi340 {\b0 \fs15 3.}{\b0 \fs15 Sebanyak}{\b0 \fs15 70%}{\b0 \fs15
responden}{\b0 \fs15 menanggapi}{\b0 \fs15 dengan}{\b0 \fs15 puas}{\b0
\fs15 rasa}{\b0 \fs15 ketiga}{\b0 \fs15 formula}{\b0 \fs15 tablet }
\fi679 {\b0 \fs15 effervescent}{\b0 \fs15 ekstrak}{\b0 \fs15 ginseng}{\b0 \fs15
jawa. }\par
}
47 \par
}
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101010
10101010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101ffdb0043010101010101010101010101010101010101010101010101010101010101010
1010101010101010101010101010101010101010101010101010101010101010101ffc0001108031802
6403012200021101031101ffc4001f00000105010101010101000000000000000001020304050607080
90a0bffc400b5100002010303020403050504040000017d010203000411051221314106135161072271
14328191a1082342b1c11552d1f02433627282090a161718191a25262728292a3435363738393a43444
5464748494a535455565758595a636465666768696a737475767778797a838485868788898a92939495
0102030405060708090a0bffc400b511000201020404030407050404000102770001020311040521310
61241510761711322328108144291a1b1c109233352f0156272d10a162434e125f11718191a26272829
2a35363738393a434445464748494a535455565758595a636465666768696a737475767778797a82838
0028a28a0028a28a0028a28a0028a28a0028a28
28a0028a28a0028a28a0028a28a0028a28a0028a28a00ffd9
}}\par}{\phpg\posx2678\pvpg\posy2165\absw7466\absh727 \b \f10 \fs16 \cf0 \b \f10
\fs16 \cf0 DAFTAR PUSTAKA
{\b0 \fs15 Anonim,}{\b0 \fs15 1979,}{\b0\i \fs15 Farmakope}{\b0\i \fs15
Indonesia}{\b0 \fs15 ,}{\b0 \fs15 Edisi}{\b0 \fs15 III,}{\b0 \fs15
Departemen}{\b0 \fs15 Kesehatan}{\b0 \fs15 Republik}{\b0 \fs15
Indonesia, }
\fi933 {\b0 \fs15 Jakarta:}{\b0 \fs15 Halaman}{\b0 \fs15 xxx,}{\b0 \fs15 6,}{\b0
\fs15 7,}{\b0 \fs15 9. }\par
}
Banker, G. S. Dan Anderson, N. R., 1986, Tablet, Dalam Lachman, L., Lieberman, H.
A., Kanig, J.
L. (Eds),{\i Teori}{\i dan}{\i Praktek}{\i Farmasi}{\i Industri},
Diterjemahkan oleh Siti Suyatmi, UI
Press, Jakarta: Halaman 645-646, 651, 653, 655, 674-679, 697-699, 701-703. \par
}
Carstensen, J. T., Chan. P.C., 1977, Flow Rates and Repose
Angles of Wet- Processed
Granulation{\i ,}{\i J.}{\i Pharm.}{\i Sci}, 66(9), p. 1235-1238 \par
}
Fassihi, A.R., Kanfer, I., 1986{\i ,} Effect of Compressibility and Powder
Flow Properties on Tablet
Weight Variation :{\i Drug}{\i Development}{\i and}{\i Industrial}{\i
Pharmacy}, Twelfth Edition, Marcel
Dekker, New York: Halaman 321-358, 1947-1966. \par
}
Hidayat, Syamsul, 2005,{\i Ginseng}{\i Multivitamin}{\i Alami}{\i
Berkhasiat}, Penebar Swadaya, Jakarta:
Halaman 3, 6-8, 13-15. \par
}
Lachman L., Lieberman, H. A., dan Kanig, J. L., 1986,{\i Teori}{\i
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}

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