Title: Solubilizing

Aim:
Prepare Salicylic acid solution (2.5%)
Material:
Salicylic acid, Propylene Glycol, Ethanol, NaOH, Metabisulfate, Water
Method:
1- Cosolvent
S.A 1.25 g
Metabisulfate 0.05 g
PG 10 ml
Ethanol 20 ml
Water 10 ml

2- Changing PH
S.A 1.25 g
Metabisulfate 0.05 g
NaOH 3.6 ml
Water 46.4 ml

S.A + NaOH → Na Salisilate

138 g 40 g
1.25 g X g X= 0.36 NaOH

For 10% solution of NaOH 10 g 100 ml

0.36 g Y ml
Y= (0.36 x 100)/10= 3.6 ml
NaOH in 10% Solution

Result:
Solubility of S.A was enhanced by adding co-solvent or by changing PH.
Conclusion:
Perparing S.A solution 2.5% by : 1- Adding co-solvent.
2- Changing PH.