24 Gy Radiation Plus Avastin ®

1
Measure MARINA
Lucentis 0.5 mg,
12 months

Number of subjects 240

Vision maintenance 95%
% of subjects losing <15 ETDRS letters

Subjects gaining 0 or more letters 71%

Subjects gaining 15 or more letters 34%
Subjects gaining 30 or more letters 4%
Mean change in visual acuity (letters) +7.2
1. Lucentis [prescribing information]. South San Francisco, CA: Genentech Inc: 2007.
Confidential 1
 24 Gy Radiation Plus Avastin ®

1
MARINA ANCHOR1 NeoVista
Measure Lucentis 0.5 mg Lucentis 0.5 mg Procedure
12 months 12 months 12 months

Number of subjects 240 139 33

Vision maintenance
95% 96.4% 94%
% of subjects losing <15 ETDRS letters

71% 77.7% 70%

Subjects gaining 0 or more letters
Subjects gaining 15 or more letters 34% 40.3% 39%
Subjects gaining 30 or more letters 4% 12.2% 12%
Mean change in visual acuity (letters) +7.2 +11.3 +10.0
1. Lucentis [prescribing information]. South San Francisco, CA: Genentech Inc: 2007.
Confidential 2