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    The document outlines the immune mediated process involved in multiple sclerosis, including how activated T cells and antibodies may lead to damage of the myelin sheath and oligodendrocytes in the central nervous system, potentially through endothelial cell penetration of the blood brain barrier and secretion of pro-inflammatory cytokines. A complex interplay between pro- and anti-inflammatory cytokines, antibodies, antigen presenting cells, and glial cells are depicted.

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    Presentation1

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    The document outlines the immune mediated process involved in multiple sclerosis, including how activated T cells and antibodies may lead to damage of the myelin sheath and oligodendrocytes in the central nervous system, potentially through endothelial cell penetration of the blood brain barrier and secretion of pro-inflammatory cytokines. A complex interplay between pro- and anti-inflammatory cytokines, antibodies, antigen presenting cells, and glial cells are depicted.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views1 page

    Presentation 1

    Uploaded by

    babbicho1642
    The document outlines the immune mediated process involved in multiple sclerosis, including how activated T cells and antibodies may lead to damage of the myelin sheath and oligodendrocytes in the central nervous system, potentially through endothelial cell penetration of the blood brain barrier and secretion of pro-inflammatory cytokines. A complex interplay between pro- and anti-inflammatory cytokines, antibodies, antigen presenting cells, and glial cells are depicted.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Auto reactive T-Cell

    adhesion Demylinating antibodies

    Endothelial cells
    Blood brain barrier

    Central Nervous
    penetration system
    Activated antigen
    presenting cell

    Interferon-Г, TNF-β Oligodendrocyte


    precursor cell

    B7-1, B7-2

    CD28 Anti inflammatory


    Class II MHC triggering IL-4,10&13
    Activated
    B cell
    Putative MS antigen
    IL-1,4&10
    IL-12 & interferon -Г
    IL-4,5,6 , Glial growth
    10 &13 factor

    TNFα,
    interferon-Г Anti Proliferation &
    bod Remyleination of
    ies
    neurons
    Cytokine
    mediated injury

    Macrophage

    Neuronal
    Complement cell body

    Immune
    Antibody mediated lesion
    mediated injury

    Class I MHC Primary


    molecule oligodendrogliopathy

    oligodendrocyte

    Degeneration of
    inner Glial loop

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