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COLON CANCER &

URINARY BLADDER
ADENOCARCINOMA

CNS preoptic Inflammatory


area cytokines Direct extension of
cancer to adjacent
organ like bladder,
Triggers prostaglandin E series abdominal muscles
& skin

Activates Bacterial
hypothalamic area to invasion
increase body
temperature
Bladder
infection (UTI)
HYPERTHERMIA

Damaged &
Detrusor inflamed
Detrusor spasm
irritation mucosa

PAIN ON
URINATION

Activated
inflammatory
response

U/A: (+) RBC,


(+)WBC, bacteria &
epithelial cells
Activation of
erythropoiesis-
inhibiting
interleukins

Secondary anemia

Tumor growth in
abdominopelvic Sense of
Decreased
region fullness
RBC,
haemoglobin
& hematocrit
Decreased
Delayed gastric food intake
emptying Decrease O2
carrying capacity

WEIGHT LOSS &


GI tract vagal MUSCLE
afferents WASTING FATIGUE

Activation of IMBALANCED
vomiting center NUTRITION

Activation of
NAUSEA & receptors found in CHEMOTHERAP
VOMITING chemoreceptor
Y
trigger zone

Loss of gastric juice Immunosuppression


& fluids

Decrease
ELECTROLYTE immunologic
IMBALANCE response

HIGH RISK FOR


INFECTION

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