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Analgesic DRUG Acetaminophen

CLASSIFICATION

MECHANISM OF ACTION Antipyretic: Reduces fever by. acting directly on the hypothalamic heat-regulating center to cause vasodilatation and sweating, which helps dissipate heat. Analgesic: It blocks the peripheral pain impulses by inhibition of prostaglandin synthesis

DOSAGE & ROUTE Adults: PO or PR By suppository, 325-650 mg q 46 hr or PO,1000 mg tid to qid. Do not exceed 4g/day. Pediatric patient: PO or PR Doses may be repeated 4-5 times/day, do not exceed 5 doses in 24 hr, give PO or by suppository.
Age 0-3 mo 4-11 mo 12-23 mo 2-3 yr 4-5 yr 6-8 yr 9-10 yr 11 yr Dosage (mg) 40 8 120 160 240 320 400 480

INDICATION  Treatment of mild to moderate pain and fever  An appropriate substitute for aspirin  Antipyretic DOC in children and adolescents with flu syndromes.

CONTRA INDICATION  Drug allergy to acetaminoph en  Severe liver disease  Genetic disease known as glucose-6phosphate dehydrogena se (G6PD) deficiency.

INTERACTIONS

ADVERSE EFFECTS     Rash Nausea Vomiting Blood dyscrasias (e.g., anemias)  Nephrotoxici ties

NURSING INTERVENTION

Antipyretic Analgegic (non-opioid)

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