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  • NA01 Structure

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    Mary Joseph
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    The document summarizes some basic structures and properties of nucleic acids. It describes that nucleotides are composed of a phosphate, sugar (ribose or deoxyribose), and a nitrogenous base. Nucleotides are linked by phosphodiester bonds to form polynucleotides. The two strands of DNA have antiparallel structures, with one strand running 5' to 3' and the other 3' to 5'. Together they form the characteristic double helix structure of DNA.

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    The document summarizes some basic structures and properties of nucleic acids. It describes that nucleotides are composed of a phosphate, sugar (ribose or deoxyribose), and a nitrogenous base. Nucleotides are linked by phosphodiester bonds to form polynucleotides. The two strands of DNA have antiparallel structures, with one strand running 5' to 3' and the other 3' to 5'. Together they form the characteristic double helix structure of DNA.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    5 views5 pages

    NA01 Structure

    Uploaded by

    Mary Joseph
    The document summarizes some basic structures and properties of nucleic acids. It describes that nucleotides are composed of a phosphate, sugar (ribose or deoxyribose), and a nitrogenous base. Nucleotides are linked by phosphodiester bonds to form polynucleotides. The two strands of DNA have antiparallel structures, with one strand running 5' to 3' and the other 3' to 5'. Together they form the characteristic double helix structure of DNA.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    of 5

    Basic Structure of Nucleic Acids

    Acid

    5 4

    Base

    1 Adenine

    Monophosphate Diphosphate Triphosphate


    3

    Sugar

    Purine Guanine Thymine Pyrimidine Cytosine 2 Uracil


    Juang RH (2004) BCbasics

    Nucleotide (Adenosine monophosphate, AMP

    Nucleoside (Adenosine)

    Ribose, Deoxyribose

    Nucleotides Linked by Phosphodiester Bond


    2 -

    PO4

    1
    3
    O O-P=O O OH
    2 -

    PO4

    2
    3 OH

    Phosphodiester bond

    5 P 1 R P 2 R P 3 R P 4 R P 5 R P 6 R 3

    Juang RH (2004) BCbasics

    A kind of phospho-polysaccharides

    The Notation for Nucleic Acids


    A T C G A T C G

    5
    P OH

    B R P 5

    1 2 3

    pApTpCpGpApTpCpG-OH 3
    5 pATCGATCG-OH 3

    ATCGATCG
    Juang RH (2004) BCbasics

    The Two Chains of DNA Are Antiparallel

    5 5

    pApTpCpGpApTpCpG-OH 3
    5
    5
    Juang RH (2004) BCbasics

    pCpGpApTpCpGpApT-OH 3
    3

    Characteristics of Double Helix

    5
    1 2 3 4 5

    36

    Small groove

    6 7 8 9 10

    Large groove

    1 Twist = 10.5 bp

    3
    Juang RH (2004) BCbasics

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