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  • Chemistry of Natural Products

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    Waleed Y. Hassan
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    This document outlines key biochemical pathways and molecules involved in the biosynthesis of natural products. It shows glycolysis and the pentose phosphate cycle contributing sugars like erythrose 4-P. Photosynthesis, the shikimic acid pathway and acetyl-CoA contribute aromatic amino acids and isoprenoids. The Krebs cycle further processes carbohydrates and amino acids into precursor molecules like alpha-ketoglutarate and acetyl-CoA that feed into secondary metabolic pathways to synthesize a wide range of natural products.

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    a biosynthetic approach

    Original Title

    Chemistry of Natural products

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    This document outlines key biochemical pathways and molecules involved in the biosynthesis of natural products. It shows glycolysis and the pentose phosphate cycle contributing sugars like erythrose 4-P. Photosynthesis, the shikimic acid pathway and acetyl-CoA contribute aromatic amino acids and isoprenoids. The Krebs cycle further processes carbohydrates and amino acids into precursor molecules like alpha-ketoglutarate and acetyl-CoA that feed into secondary metabolic pathways to synthesize a wide range of natural products.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    40 views2 pages

    Chemistry of Natural Products

    Uploaded by

    Waleed Y. Hassan
    This document outlines key biochemical pathways and molecules involved in the biosynthesis of natural products. It shows glycolysis and the pentose phosphate cycle contributing sugars like erythrose 4-P. Photosynthesis, the shikimic acid pathway and acetyl-CoA contribute aromatic amino acids and isoprenoids. The Krebs cycle further processes carbohydrates and amino acids into precursor molecules like alpha-ketoglutarate and acetyl-CoA that feed into secondary metabolic pathways to synthesize a wide range of natural products.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
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    of 2

    Chemistry of Natural Products A Biosynthetic approach

    GLYCOLYSIS OH O HO OH OH OH OH PO OH OH O OH Pentose Phosphate Cycle PO OH erythrose 4-P OH O Photosynthesis

    Glucose 6-P CO2H


    NH2 Glycine CO2H HS NH2 L-Cysteine HO NH2 L-serine PO 3-phosphoglyceric acid HO OH SHIKMIC ACID NH2 CO2H NH2 L-Valine CO2H HO2C O O Pyruvic acid \ CO2H NH2 L-leucine ACETYL-CoA KREBS CYCLE CO2H NH2 L-isoleucine CO2H S NH2 L-methionine NH2 L-lysine H2N HO2C CO2H NH2 L-aspartic acid CO2H HO2C O Oxaloacetic acid NH H2N N H L-arginine CO2H NH2 H2N L-ornithine CO2H NH2 CO2H HO2C CO2H HO2C NH2 L-glutamic Acid CO2H CoAS O HO2C OH MEVALONIC ACID OH OH HO2C OP NH Phosphoenolpyruvate OH OP deoxyxylulose 5-P OH HO L-tyrosine NH2 CO2H CO2H

    OHC
    PO

    OH
    CO2H

    glyceraldehyde 3-P CO2H HO2C OH

    NH2 L-Phenylalanine CO 2H

    O 2- oxoglutaric acid

    BY: Prof.M.H El-Nagd ............................................................................


    PAGE 3

    Chemistry of Natural Products A Biosynthetic approach

    BY: Prof.M.H El-Nagd .........................................................................


    PAGE 3

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