HMP SHUNT PATHWAY

Pathways that Require NADPH

Detoxification:

 Reduction of oxidized glutathione

 Cytochrome P450 mono-oxygenases
 Reductive Synthesis
 Fatty acid synthesis
 Fatty acid chain elongation
 Cholesterol synthesis
 Steroid synthesis
 Deoxyribonucleotide synthesis

Metabolites in HMP Shunt Pathway:

 Glucose 6 Phosphate
 6 Phosphogluconate
 Ribulose 5 Phosphate
 Xylulose 5 Phosphate
 Ribose 5 Phosphate
 Glyceraldehyde 3 Phosphate
 Sedoheptulose 7 Phosphate
 Fructose 6 phosphate
 Erythrose 4 Phosphate

Key points to remember in HMP (Pentose Phosphate) Pathway:

 Main source of NADPH02012and Pentoses.

 Two transketolation and one transaldolation reactions areinvolved.
 No ATP is produced.
 CO2 is produced in this pathway and not in glycolytic Pathway.
 Deficiency of Glucose 6 phosphate dehydrogenase is a majorcause of acute hemolysis in
erythrocytes.
 NADPH is used for reductive biosynthetic pathways, likefatty acid synthesis, steroid
synthesis, Amino acids by Glutamatedehydrogenase.
 NADPH is required for regeneration of reduced Glutathione,that clears free radicals from
erythrocytes and lens.
 Wernicke's Korsakoff's syndrome is exacerbated by defect intransketolase.