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  • Pentose Phosphate Pathway 13

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    savinder singh
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    The document discusses the pentose phosphate pathway (PPP), also known as the hexose monophosphate pathway (HMP). It has two main functions: to provide NADPH for reductive biosynthesis and to provide ribose-5-phosphate for nucleotide and nucleic acid biosynthesis. The pathway consists of an oxidative phase that forms NADPH and CO2, and a non-oxidative phase that forms ribose-5-phosphate. A deficiency in glucose-6-phosphate dehydrogenase (G6PD) can cause hemolytic anemia by reducing the ability to detoxify oxidizing agents. The net reaction of the oxidative phase generates 2 molecules of NADPH, oxidizes 1 carbon to CO2,

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    Pentose phosphate pathway by Prof.Dr.Savinder Singh

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    pentose phosphate pathway 13

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    The document discusses the pentose phosphate pathway (PPP), also known as the hexose monophosphate pathway (HMP). It has two main functions: to provide NADPH for reductive biosynthesis and to provide ribose-5-phosphate for nucleotide and nucleic acid biosynthesis. The pathway consists of an oxidative phase that forms NADPH and CO2, and a non-oxidative phase that forms ribose-5-phosphate. A deficiency in glucose-6-phosphate dehydrogenase (G6PD) can cause hemolytic anemia by reducing the ability to detoxify oxidizing agents. The net reaction of the oxidative phase generates 2 molecules of NADPH, oxidizes 1 carbon to CO2,

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    2 views8 pages

    Pentose Phosphate Pathway 13

    Uploaded by

    savinder singh
    The document discusses the pentose phosphate pathway (PPP), also known as the hexose monophosphate pathway (HMP). It has two main functions: to provide NADPH for reductive biosynthesis and to provide ribose-5-phosphate for nucleotide and nucleic acid biosynthesis. The pathway consists of an oxidative phase that forms NADPH and CO2, and a non-oxidative phase that forms ribose-5-phosphate. A deficiency in glucose-6-phosphate dehydrogenase (G6PD) can cause hemolytic anemia by reducing the ability to detoxify oxidizing agents. The net reaction of the oxidative phase generates 2 molecules of NADPH, oxidizes 1 carbon to CO2,

    Copyright:

    © All Rights Reserved
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    of 8

    Metabolism Lecture -13

    Pentose phosphate pathway (PPP)

    Hexose monophosphate pathway (HMP).

    Phosphogluconate Pathway
    😀😀😀😀😀😀😀😀😀
    HMP Shunt
    • Alternative to Glucose oxidation .
    • Enzyme Location – Cytosol, plastids(plant)
    • Function:--
    1. To provide NADPH for Reductive Biosynthesis
    2. To provide ribose -5-, Phosphate for nucleotide and nucleic acid biosynthesis.
    • The sequence of reactions of HMP shunt is divided into two phase .
    1. Oxidative (Irreversible) = Formation of NADPH & CO2.
    2. Non – Oxidative ( Reversible) = Formation of Ribose 5 phosphate
    • G6PD deficiency is an X – Linked recessive disease, G6PD deficiency result in
    hemolytic anemia caused by the inability to detoxify oxidizing agent.
    • In a 1 cycle net result of the oxidative phase is generation of 2 mole of NADPH,
    oxidation of 1 carbon to CO2, and the synthesis of 1mole of Pentose phosphate.
    6 NADP+  6 NADPH
    3 × G3P ------------------------- 3 × Ru5P + 3 × CO2

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