1. What is HMP shunt?

2. What is the significance of HMP shunt?

3. Where does HMP shunt happen?
4. Where is this pathway active?
5. What is the overview of the pathway?
6. NADPH acts as what type of regulator for g6p dehydrogenase?
7. What promotes G6P dehydrogenase gene?
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14. Glucose 6 phosphate starts HMP shunt.
HMP shunt is about oxidizing and generating NADPH, this is crucial in regenerating Glutathione
(GSH) for rbc life. Without GSH the rbcs cause hemolytic anemia. Ribose 5 phosphate is the
backbone for nucleic acids. G6p deficiency causes Heinz bodies hemolytic anemia. NADPH
deficiency cause thriving of bacteria.
1. It is an alternative pathway for glucose (glucose 6 phosphate is shunted away form
glycolysis). NO ATP is produced during this pathway.
2. It produces NADPH +H that is required for anabolism, defense, production of
neurotransmitter, and produces Ribose 5-phosphate required for synthesis of nucleotides
and nucleic acids.
3. The HMP shunt pathway happens in the cytosol of erythrocytes, white blood cells, liver,
adipose tissue, adrenal cortex, testes, ovaries, lactating mammary gland , thyroid glands.
4. It is active in tissues involving the maintenance of glutathione in reduced state, synthesis
of fatty acids, cholesterol and sterols, detoxification of drugs that use cytochrome P450
5.
6. Negative (inhibitor)
7. Insulin
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