MBS 330-MEDICAL BIOCHEMISTRY II

(Term 1 DEFERRED TEST)/ CBU-SOM

BASIC MEDICAL SCIENCES

Answer all questions in this paper. There are 50 Multiple Choice Questions
(MCQs). Choose the most appropriate answer.

Which one of the following cannot convert glucose to Vitamin C? 1 point

Dogs

Albino rats

Cows

Monkeys

Which of the following is not an enzyme involved in glycolysis? 1 point

Aldolase

Enolase

Glucose oxidase

Hexokinase
Fatty acids cannot be converted into carbohydrates in the body as the 1 point

following reaction is not possible:

Formation of acetyl CoA from fatty acids

Fructose 1, 6-bisphosphate to fructose-6-phosphate

Conversion of glucose-6-phosphate into glucose

Transformation of acetyl CoA to pyruvate

Two conditions in which gluconeogenesis is increased are; 1 point

Diabetes mellitus and atherosclerosis

Alcohol intake and cigarette smoking

Fed condition and thyrotoxicosis

Diabetes mellitus and Starvation

The following metabolic abnormalities occur in Diabetes mellitus except; 1 point

Decreased lipogenesis

Increased plasma FFA

Decreased gluconeogenesis

Increased pyruvate carboxylase activate

The branching enzyme acts on the glycogen when the glycogen chain has 1 point
been lengthened to between glucose units:

1 and 6

6 and 11

3 and 9

2 and 7

How many ATPs are produced in the conversion of phosphoenol pyruvate 1 point
to citrate?

Serum cholesterol is decreased in; 1 point

Myxoedema

Thyrotoxicosis

Endemic goitre

Cretinism
Polyuria can occur in; 1 point

Diarrhoea

High fever

Diabetes mellitus

Acute glomerulonephritis

Obesity increases the risk of; 1 point

Diabetes mellitus

All of the mentioned options

Hypertension

Cardiovascular disease

Cori’s cycle transfers; 1 point

Pyruvate from liver to muscles

Lactate from muscles to liver

Glucose from muscles to liver

Lactate from liver to muscles

Tricarboxylic acid cycle to be continuous requires the regeneration of; 1 point

Alpha-oxoglutaric acid

Malic acid

Pyruvic acid

oxaloacetic acid

Which of the following is a substrate for aldolase in Glycolytic pathway? 1 point

Glyceraldehyde-3-p

Glucose-6-p

Fructose-6-p

Fructose1, 6-bisphosphate

Glycogenin is; 1 point

Polymer of glycogen molecules

Protein primer for glycogen synthesis

Intermediate in glycogen breakdown

Uncoupler of oxidative phosphorylation

The blood sugar raising action of the hormones of suprarenal cortex is due 1 point

to;

Glucagon-like activity

Gluconeogenesis

Glycogenolysis

Due to inhibition of glomerular filtration

In conversion of Lactic acid to Glucose, three reactions of Glycolytic 1 point

pathway are circumvented, which of the following enzymes do not
participate?

Pyruvate Carboxylase

Glucose-6-phosphatase

Phosphoenol pyruvate carboxy kinase

Pyruvate kinase

A substance that is not an intermediate in the formation of D-glucuronic 1 point

acid from glucose is;

UDP-Glucose

Glucose-6-p

6-Phosphogluconate
 Glucoss-1-p

Glycogen structure includes a branch in between________glucose units. 1 point

8–14

12–18

6–10

6–12

Hexokinase has a high affinity for glucose than; 1 point

Fructokinase

Glucokinase

All of the options mentioned

Galactokinase

Under anaerobic conditions the glycolysis of one mole of glucose yields 1 point

______moles of ATP.

Eight

One

Thirty

Two
Transketolase has the coenzyme: 1 point

TPP

FP

Pyridoxol phosphate

NAD+

Gluconeogenesis is increased in the following condition: 1 point

Hypothyroidism

Diabetes Mellitus

Diabetes insipidus

Liver diseases

Rothera's test is not given by 1 point

None of the mentioned options

Bile salts

Glucose

Beta-hydroxy butyrate
An anaplerotic reaction which sustains the availability of oxaloacetate is 1 point

the carboxylation of;

Succinate

Citrate

Glutamate

Pyruvate

Heavy proteinuria occurs in; 1 point

Acute glomerulonephritis

Nephrotic syndrome

Nephrosclerosis

Acute pyelonephritis

The heptose ketose sugar formed as a result of chemical reaction in HMP 1 point

shunt:

Mannoheptose

Galactoheptose

Glucoheptose

Sedoheptulose
Amylo 1, 6 glucosidase is called; 1 point

Debranching enzyme

Branching enzyme

Phosphorylase

Glucantransferase

Glycogen synthetase activity is depressed by; 1 point

Glucose

Fructokinase

Cyclic AMP

Insulin

Dehydrogenase enzymes of the hexose monophosphate shunt (HMP) are; 1 point

FAD specific

NADP+ specific

FMN specific

NAD+ specific
The conversion of alanine to glucose is termed; 1 point

Glycolysis

Gluconeogenesis

Specific dynamic action

Oxidative decarboxylation

Phenylalanine is the precursor of; 1 point

Throxine

L-DOPA

Histamine

Tyrosine

The tissues with the highest total glycogen content are; 1 point

Liver and muscle

Muscle and kidneys

Kidneys and liver

Brain and Liver

The “Primaquine sensitivity types of haemolytic anaemia has been found 1 point
related to reduced R.B.C activity of which enzyme?

Hexokinase deficiency

Glucose-6-p dehydrogenase deficiency

Pyruvate kinase deficiency

Glucose-6-phosphatase deficiency

Glucosamine is an important constituent of; 1 point

Heteropolysaccharide

Homopolysaccharide

Dextran

Mucopolysaccharide

During starvation, ketone bodies are used as a fuel by; 1 point

Liver

Erythrocytes

Brain

All of the the mentioned options

The ratio that approximates the number of net molecule of ATP formed per 1 point
mole of Glucose oxidized in presence of oxygen to the net number formed
in abscence of oxygen is;

4:1

12 : 1

10 : 2

18 : 1

Dihydroxyacetone phosphate and glyceraldehyde-3-phosphate are 1 point

interconverted by;

Triose isomerase

Phosphotriose isomerase

Diphosphotriose isomerase

Dihydroxyacetone phosphorylase

Excessive intake of ethanol increases the ratio of: 1 point

NAD+ : NADH

FADH2 : FAD

FAD : FADH2

NADH : NAD+
 NADH : NAD+

The hydrolysis of Glucose-6-P is catalysed by a phosphatase that is not 1 point

formed in which of the following?

Muscle

Kidney

Small intestine

Liver

Compared to the resting state, vigorously contracting muscle shows; 1 point

Decreased concentration of AMP

A decreased NADH/NAD+ ratio

Decreased oxidation of pyruvate of CO2 and water

An increased conversion of pyruvate to lactate

Galactose is a main constituent of; 1 point

Chitin

Honey

Cane sugar

Milk sugar
Glycogen is converted to glucose-1-phosphate by; 1 point

Branching enzyme

Phosphorylase

UDPG transferase

Phosphatase

Cyclic AMP is formed from ATP by the enzyme adenylate cyclase which is 1 point
activated by the hormone:

Progesterone

Testosterone

Insulin

Epinephrine

In the diet of a diabetic patient, the recommended carbohydrate intake 1 point

should preferably be in the form of;

All of the mentioned options

Monosaccharides

Polysaccharides

Dissaccharides
An essential for converting Glucose to Glycogen in Liver is; 1 point

CTP

Lactic acid

UTP

GTP

UDP-glucuronic acid is required for the biosynthesis of; 1 point

Glycogen

Starch

Lactose

Chondroitin sulphates

Animal fat is in general: 1 point

Rich in saturated and polyunsaturated fatty acids

Rich in saturated and poor in polyunsaturated fatty acids

Poor in saturated and rich in polyunsaturated fatty acids

Poor in saturated and polyunsaturated fatty Acids

Dehydrogenation of succinic acid to fumaric acid requires the following 1 point
hydrogen carrier:

NAD+

flavoprotein

Glutathione

NADP+

Ethanol decreases gluconeogenesis by; 1 point

Converting NAD+ into NADH and decreasing the availability of pyruvate

Inhibiting glucose-6-phosphatase

Converting NAD+ into NADH and decreasing the availability of lactate

Inhibiting PEP carboxykinase

Reduced glutathione functions in R.B.Cs to; 1 point

Produce NADH

Produce NADPH

Reduce oxidizing agents such as H2O2

Reduce methemoglobin to hemoglobin

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