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Salivary Gland Tumors
Salivary Gland Tumors
Benign Malignant
Pleomorphic Adenoma
It is the most common benign salivary gland tumor composed predominantly by the proliferation of the myoepithelial cells and a wide spectrum of the epithelial and the mesenchymal tissue component surrounded by a distinctive capsule.
Pleomorphic Adenoma
Pleomorphic Adenoma
CLINICAL FEATURES: PA accounts for 60% of all parotid gland tumors,50% of submandibular tumors and 25% of sublingual tumors PA is encountered in patients of all ages. PA is a slow growing tumor. It is soft or slightly firm on palpation and on larger gland it is freely movable. In parotid glands the tumor id spherical and arises in the superficial lobe as an obvious mass. In minor gland there is soft to slightly firm swelling without any ulceration.
Pleomorphic Adenoma
Pleomorphic Adenoma
Pleomorphic Adenoma
DIAGNOSIS: MRI is the most reliable source of diagnosis and to determine the extent of the disease particularly in the major salivary glands. Biopsy has always been a best tool for the definitive diagnosis.
Pleomorphic Adenoma
HISTOPATHOLOGY: In PA there is presence of a pronounced fibrous capsule. This is the most important histological feature when distinguishing between the benign and the malignant tumors Some lesions of the long standing lesions are multinodular and each nodule is surrounded by the fibrous capsule. The tumor cells shoe wide variation of the cells involved that is why the name pleomorphic has been given. The most prominent pattern contains the ductal and the myoepithelial cells contd
Pleomorphic Adenoma
Sheets of the myoepithelial cells loose there typical spindle shape becoming polygonal with eccentric nuclei with hyalinized cytoplasm. Although PA,s are well capsulated it uncommon for the tumor cells to perforate the capsule and creating new tumor foci. There is less than 1% chances of malignant transformation for those which have undergone recurrences. The tumors are termed as Carcinoma ex. Pleomorphic adenoma.
Pleomorphic Adenoma
Pleomorphic Adenoma
Pleomorphic Adenoma
TREATMENT: Lobulectomy is done in the larger salivary glands. Enucleation is not done because of the chances of recurrence (deposition) of exracapsular foci of tumor cells) PA,s of the lip are enucleated as there chances of recurrence are minimal as some normal tissue is also excised with the tumor.
Pleomorphic Adenoma
Monomorphic adenoma
Monomorphic adenomas lack wide cellular diversity as seen in pleomorphic adenomas. They are composed of single cell type that is why term monomorphic has been used There are to distinct entities in this group: 1. The Basal cell Adenoma 2. Canalicular adenoma
Canalicular Adenoma
CLINICAL FEATURES: The lesion originates from the intraoral accessory salivary glands. It occurs in the upper lip and there are instances when it occurs on the palate or the buccal mucosa. The tumor is a well circumscribed firm nodule which is not fixed and moves through the tissues.
Canalicular Adenoma
HISTOPATHOLOGY: There long strands or cords of epithelial cells, arranged in a double row There cystic spaces of varying sizes enclosed by these cords. The cystic spaces are filled with eosinophilic coagulum. The supporting stroma is loose and fibrillar with delicate vascularity.
Canalicular Adenoma
Canalicular Adenoma
TREATMENT: Enucleation or surgical excision can be done. Recurrence is rare.