Researches to prove the clinical efficacy of Lactobacillus casei Shirota

1. Aso Y., et al. Preventive effect of a Lactobacillus casei preparation on the recurrence of

superficial bladder cancer in a double-blind trial. European Urology, 27: 104-109, 1995. 2. Ohashi Y., et al. Habitual intake of Lactic acid bacteria and risk reduction of bladder cancer. Urologia Internationalis, 68: 273-280, 2002. 3. Koebnick, C. et al. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can. J. Gastroenterol, 17: 655-659, 2003. 4. Candy, D.C.A. et al. Effect of administration of Lactobacillus casei Shirota on sodium balance in an infant with short bowel syndrome. J. Pediatr. Gastroenterol, Nutr: 32, 506-508, 2001. 5. Kanamori, Y. et al. Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically Improved the intestinal function in a girl with short bowel syndromeA novel Synbiotic therapy for Intestinal failure. Digestive diseases and Science, 46: 2010-2016, 2001. 6. Ishikawa, H. et al. Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors. Int. J. Cancer, 20:762-763, 2005. 7. Kanazawa, H. et al. Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy. Langenbecks Arch. Surg, 390:104-113, 2005. 8. Sugawara, G. et al. 714, 2006. 9. Matsuzaki, T. et al. A prospective uncontrolled trial of fermented milk drink containing viable Lactobacillus casei strain Shirota in the treatment of HTLV-1 associated myelopathy/tropical spastic paraparesis. J. Neurol. Sci, 15:75-81, 2005. Perioperative synbiotic treatment to prevent postoperative infectious Ann. Surg, 244:706complications in biliary cancer surgery: a randomized controlled trial.