Tablet composition

Diluent (frtunningsmedel, utspdningsmedel) Dicalcium phosphate Lactose Mannitol Starch Magnesium stearate Cellulose Diluent properties * To provide improved cohesion * To allow direct compression manufacturing * To enhance flow * To adjust weight of tablet as per die capacity Lubricant (glidmedel, smrjmedel) Magnesium stearate (especially in tablet formulations) Lubricant properties: * Improves flow properties of granules * Reduces powder adhesion onto the dies and punches * Reduces punsch and die wear * Faciliates tablet ejection from the die * Water insoluble ( difficult to wet) Glidant Talc Sweetener Aspartame Mannitol Bulking agent (gr partiklarna strre s att man ser nr mnet r lst) Mannitol Antimicrobial perservative Benzyl alhocol Propyl Methyl Benzyl Antiadherent Colloidal silica Sodium lauryl sulfate Cornstarch Stearates

Antiadherent * Aiding picking by puches * Avoiding sticking to die walls Colourants * Facilitate identification of similar looking products with in a product line to avoid confusion * To overcome colour change on aging * To enhance the aesthetic appearance of the product to have better patient compliance * For brand image in the market Pregelatinized Starch can be used as a (multifunctional excipient): * Disintegrant * Flow aid * Diluent * Tablet binder Tablet disintegrant Starch Cellulose Alignates Ion-echange resins Chelating agents (wetting agent) Aids water uptake and thereby enhancing disintegration and assisting in drug dissolution. Chelator Tartaric Acid Granule formation steps 1) Nucleation 2) Transition 3) Ball growth Colorant Indigotine Erythrosin Tartrazine Emulsifying agent Other names: Wetting agents, surfactants, surfactive agents. It lowers the surface and interfacial tension. These agents permit more inimate contact between an aqueous phase and a lipid phase. Emulsifying agents Soaps

Sodium lauryl sulfate Dioctyl sodium