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56806449 NAPLEX Calc Practice

# 56806449 NAPLEX Calc Practice

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09/18/2014

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# 1. If a drug solution containing 10 mg/ ml is prescribed to be taken 2 ml every 8 hours, what volume should be dispensed for a 7 day supply?

a) 30 ml b) 42 ml c) 48 ml d) 60 ml e) 64 ml Hint: Every 8 hours = 3 times/day 2. Approximately how many mg of ZnSO4. 4H20 will contain the same amount of ZnSO4 as 200 mg of anhydrous zinc sulphate? Molecular weights: ZnSO4 = 161, H2O = 18. a) 186 mg b) 257 mg c) 289 mg d) 376 mg e) 486 mg Hint: 161 mg of anhydrous zinc sulphate is present in {161 + (4 x 18) = 233} mg of ZnSO4. 4H20 3. A prescription order calls for 120 gm of 0.01% fluocinolone acetonide cream. How much cream base (additive) will you add to 0.2% fluocinolone acetonide to prepare this prescription? a) 119.8 gm b) 117.0 gm c) 114.0 gm d) 113.6 gm e) 107.4 gm Hint: Alligation method, cream base = 0% fluocinolone acetonide 4. A drug reaches a plasma concentration of 18 micrograms/ml twelve hours after IV dose of 500 mg. If it is known that the half life of this drug is 6 hours, how long after administration of first dose will it reach 4.5 micrograms/ml of plasma concentration? a) 12 hours b) 18 hours c) 24 hours d) 30 hours e) 36 hours

How many milligrams of a drug is required to prepare 150 ml of a 0. by what factor will the rate of the reaction change when concentration of one of the reactants is doubled? a) 2 b) 3 c) 4 d) 8 e) 12 Hint: Kinetics. If a reaction follows third order kinetics.4 e) 9. 5. Unionized base = 100% base & 0% salt 6.2.Hint: Drug concentration reduces to half every 6 hours. If the ratio of ionized to un-ionized drug in a solution is 10:1 and the drug has a pKa of 6.6 b) 7. log 10 = 1 7.8 d) 8. A weakly basic drug has a pKa of 6. What must be the least alkaline pH value of a solution to prevent ionization of this drug? a) 4 b) 8 c) 10 d) 12 e) 14 Hint: pH = pKa + log base/salt. third order formula. 8.8% w/v solution? a) 80 b) 120 c) 800 d) 1200 e) 1500 Hint: 1% w/v refers to 1 gm (1000 mg) of drug in 100 ml of solution. what is the pH of the solution? a) 6.2 c) 7.6 Hint: pH = pKa + log salt/acid. .

5 e) 7.0% w/w Hint: Weight of 1000 ml glycerin = 1.0745 d) 74. . the concentration of the drug in the solution is: a) 25.00 b) 36.5 milliliters of 10% w/v KCl = 250 mg KCL. one milliequivalent weight of KCl = 74. a) 25.39 c) 0.50 d) 78.12 Hint: Alligation method.5% w/w d) 10.5 mg 12.5 milliliters of 10% w/v KCl solution if molecular weight of KCl is given to be 74.45 Hint: 2.5% w/w e) 10.35 b) 0. What is the prevalence ratio if 27 people in a population of 500 were affected by a disease and only 17 got reported? a) 17/27 b) 17/500 c) 27/500 d) 27/17 e) 500/17 Hint: Prevalence ratio is the ratio of number of people affected to the total population.25 x 1000 = 1250 gm 11.0% w/w c) 12. A pharmacist has 1 lb of 5% w/w drug in ointment form.5? a) 3.25 g/mL).9.35 e) 85.78 c) 45.0% w/w b) 20. How many milliequivalents of K+ are in 2. How many grams of powdered drug must be added to obtain a 20% w/w strength. 1 lb = 454 gm 10. If 250 g of a drug is dissolved in 1000 mL of glycerin (density of glycerin being 1.

The AUC of Plasma Concentration vs Time for 100 mg drug administered by IV route is 12 mcg/ml and AUC for 250 mg of same drug administered orally is 15 mcg/ml.5) solution contains 100 mEq of K+ ? a) 0. 250 mg of the drug when administered IV will give AUC of 30 mcg/ml compared to 15 mcg/ml achieved orally. How many milliliters of a 20% KCl (Mol Wt = 74.3 mg e) 3.75 e) 72 Hint: Proportionately.06 Kg 16. how long will it take for 75% of the drug to be eliminated? a) 2 hours b) 4 hours c) 8 hours d) 12 hours e) 16 hours Hint: 75% of any drug will be eliminated in 2 half life period.6 mg Hint: 42 lb = 19.5 c) 50 d) 63. what dose should be given to a 6 years old child who weighs 42 Pounds? a) 10.25 mg/Kg. The dose of a drug is 0. Approximately.50 Hint: 100 mEq of potassium is present in 7450 mg of KCl.25 c) 0.03725 b) 37. 14.4 mg c) 4.0745 d) 74.50 e) 35. What percentage of the drug was absorbed when given orally? a) 25 b) 37.7 mg d) 0.5 mg b) 0. 15.13. 20% KCl is 20gm of KCl per 100 ml of solution . Given that T1/2 is 2 hours.

how long will it take to degrade 90% of the drug? a) 375 minutes b) 377 minutes c) 398 minutes d) 401 minutes e) 403 minutes Hint: k = 0.17. .88 Hint: TOR = Total Cost of Goods/Average Inventory 20. T = 2. Calculate the "turn over rate" of a pharmacy given that Total Sales: \$1.55 b) 13. An item is reduced in price by 10% and the number of units sold has increased by 15%.0 c) 5. (Molecular Weight of Dextrose: 180) a) 1.0 e) 2.000 Profit Margin: 25% Average Inventory: \$90.3 (log Co/C)/k 19.0 d) 25.000.693/T1/2.3 Hint: For non-electrolytes.77 e) 8.11 d) 9.3 e) 833. 1 milliosmole is represented by 1 millimole.5 Hint: Coefficient of elasticity = Change in sales/Change in price 18.22 c) 11.000 a) 15. Given that T1/2 of a drug is 120 minutes.7 d) 533.2 b) 180 c) 277. Find the value of mOsmols of Dextrose in one liter of D5W. what is the coefficient of elasticity? a) 1.5 b) 1.

25% e) 0.9% NaCl. what will be the final concentration? a) 0.2% d) 0.(milliliters of stock solution used) 24.05% c) 0. 250mg? a) 100 b) 250 c) 300 d) 750 e) 900 Hint: Isotonic solution is equivalent to 0. How many milliliters of water is required to make an isotonic solution using 9 tablets of NaCl. A 170 pound patient receives 1. milliliters of diluent required = 480 . If 20 ml of a 10% stock solution is diluted to 500 ml.21. 1gm of protein provides 4 calories.01% b) 0. . 23.4% Hint: Concentration of a solution is inversely proportional to the dilution factor which in this case is 500/20 = 25 22. How many milliliters of diluent is needed to compound 480 ml of theophylline 80 mg/10ml from a stock solution of theophylline 160 mg/15ml? a) 80 b) 100 c) 120 d) 160 e) 180 Hint: Total amount of theophylline required: 480 x 80/10 mg. how many protein calories does he receive in 24 hours? a) 370 b) 816 c) 1836 d) 204 e) 93 Hint: 170 lb = 77. Approximately.2 g/kg/day of protein.18 kg.

19 and that of dextrose is 0.1 parts per 100 28.12 d) 0. A prescription read: amethocaine 0.5 and the pH of a patient's urine is 7.1% in parts per million will produce a value of: a) 1 ppm b) 10 ppm c) 100 ppm d) 1000 ppm e) 2 ppm Hint: 1 million = 1. 0.24 b) 4.000.48 c) 1.18).s. 25 ml of isotonic solution must contain NaCl equivalent of 0. How many milliliters of this solution must be injected to provide a patient with 400 mcg of active drug? a) 5.28 Hint: NaCl equivalent represents amount of NaCl that is equivalent to the amount of the substance in consideration.50 c) 0.25 e) 2.225 gm of both ingredients in question.56 e) 0.4 mg of active drug is present in (50/8) x 0.25. How many grams of anhydrous dextrose is required to prepare the prescription? a) 2.4 mg. If a drug has a pKa valueof 5. what will be the ratio of dissociated to undissociated drug? a) 100 : 1 b) 1 : 100 c) 2 : 1 d) 1 : 2 e) Drug will remain undissociated Hint: pH = pKa + log salt/acid.5% mixed with q. Dextrose to form 25 ml of isotonic solution (given that NaCl equivalent of amethocaine is 0.63 d) 1. 27.50 Hint: 400 mcg = 0.5. .00 b) 7. A 50 ml of stock solution contains 8 mg of active drug. Expressing the concentration of 0. log 100/1 = 2 26.000 & 0.1% = 0.4 ml of stock solution.

5 mg KCl. approximately what fraction of the drug would be ionized at pH 8.5 Hint: 1 millimole of potassium is present in 74.29.4? a) 5% b) 10% c) 50% d) 90% e) 100% Hint: Hint: pH = pKa + log salt/acid 31. 30. If the IV tubing has a calibration of 20 drops/ml. .5 ml/minute 32.4.8 c) 39.2 e) 74. If the pKa of a drug is 7. 5000 units/500 ml is 5000/500 = 10 units/ml.4 b) 26. A prescription calls for an order for an IV infusion rate of 30 ml/hour.0 d) 37.5) a) 13. what must be the rate of flow? a) 5 drops/minute b) 10 drops/minute c) 15 drops/minute d) 20 drops/minute e) 30 drops/minute Hint: 30 ml/hour = 30 ml/60 minutes = 0. How many milliliters of IV solution should be infused per minute in order to provide the patient with 600 units of Heparin per hour if the IV bag contains 5000 units of Heparin in 500 ml of D5W? a) 1 b) 6 c) 10 d) 60 e) 12 Hint: 600 units/hour provides 600/60 = 10 units/minute. Approximately how many millimoles of potassium are present in 1 gm of potassium chloride? (Molecular Weight of KCl: 74.

2 ml b) 0.5 ml d) 0. . female patient will have value of 0. the pharmacist should add how many milliliters of diluent? a) 8700 b) 7500 c) 750 d) 725 e) 650 Hint: Dilution factor = 9000/300 = 30. How many milliliters of a 3 mEq/ml solution of sodium chloride is required to prepare 1000 ml of TPN solution specifying 60 mEq sodium chloride? a) 10 ml b) 20 ml c) 30 ml d) 50 ml e) 60 ml Hint: 3 mEq of sodium chloride is present in one milliliter of solution.6 ml e) 0.75 mg/dl d) 1.85 of the value calculated for males. 60 mEq will be present in 60/3 ml solution. 34.8 ml Hint: Ratio & Proportion method.30 mg/dl e) 1. final volume = 25 x 30 = 750 (725 + 25) 36. How much of a liquid drug is present in 4000 ml of a 1:5000 solution? a) 0. A 25 year old female weighing 120 pound has a creatinine clearance rate of 115 ml/min. In order to prepare a 1:9000 solution from 25 cc of a 1:300 solution.64 mg/dl c) 0. What is the serum creatinine concentration for this patient? a) 0.50 mg/dl b) 0.50 mg/dl Hint: Cockroft and Gault equation. 35.4 ml c) 0.33.

Vd = IV Dose/Cmax 38.37.14 c) 0.9% NaCl) = 0. calculate the value for 24 hours. Wt. What is the elimination rate constant of this drug? a) 0. What is the apparent volume of distribution? a) 17500 ml b) 27500 ml c) 37500 ml d) 57500 ml e) 60000 ml Hint: 750 mg = 750000 mcg.2 e) 480. of NaCl = 58.0 d) 369.484 kg . A 150 pound male patient has renal clearance rate of 21.17 d) 0. A 140 pound female patient receives an IV dose of 750 mg of a drug with Cmax of 20 mcg/ml.6 c) 240.5 Hint: Elimination rate constant = Renal clearance/Volume of distribution 39.5) a) 0. A prescription calls for 10 mg/kg/dose for a child weighing 40 pounds to be administered for 20 doses. How many milligrams of the drug is required to prepare the prescription? a) 182 b) 400 c) 6374 d) 1816 e) 3632 Hint: One pound = 0.10 b) 0.22 e) 15.7 liters/hour for a drug and volume of distribution of 1.45% NaCl.0 Hint: 1/2NS = 1/2 (0. How many milliequivalents of sodium will a patient receive per day from the infusion of D5W 1/2NS at the rate of 130 ml/hr? (Mol.58 b) 184.4 liters/kg. 40.

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