1. If a drug solution containing 10 mg/ ml is prescribed to be taken 2 ml every 8 hours, what volume should be dispensed for a 7 day supply?

a) 30 ml b) 42 ml c) 48 ml d) 60 ml e) 64 ml Hint: Every 8 hours = 3 times/day 2. Approximately how many mg of ZnSO4. 4H20 will contain the same amount of ZnSO4 as 200 mg of anhydrous zinc sulphate? Molecular weights: ZnSO4 = 161, H2O = 18. a) 186 mg b) 257 mg c) 289 mg d) 376 mg e) 486 mg Hint: 161 mg of anhydrous zinc sulphate is present in {161 + (4 x 18) = 233} mg of ZnSO4. 4H20 3. A prescription order calls for 120 gm of 0.01% fluocinolone acetonide cream. How much cream base (additive) will you add to 0.2% fluocinolone acetonide to prepare this prescription? a) 119.8 gm b) 117.0 gm c) 114.0 gm d) 113.6 gm e) 107.4 gm Hint: Alligation method, cream base = 0% fluocinolone acetonide 4. A drug reaches a plasma concentration of 18 micrograms/ml twelve hours after IV dose of 500 mg. If it is known that the half life of this drug is 6 hours, how long after administration of first dose will it reach 4.5 micrograms/ml of plasma concentration? a) 12 hours b) 18 hours c) 24 hours d) 30 hours e) 36 hours

Hint: Drug concentration reduces to half every 6 hours. 5. A weakly basic drug has a pKa of 6. What must be the least alkaline pH value of a solution to prevent ionization of this drug? a) 4 b) 8 c) 10 d) 12 e) 14 Hint: pH = pKa + log base/salt, Unionized base = 100% base & 0% salt 6. If the ratio of ionized to un-ionized drug in a solution is 10:1 and the drug has a pKa of 6.2, what is the pH of the solution? a) 6.6 b) 7.2 c) 7.8 d) 8.4 e) 9.6 Hint: pH = pKa + log salt/acid, log 10 = 1 7. How many milligrams of a drug is required to prepare 150 ml of a 0.8% w/v solution? a) 80 b) 120 c) 800 d) 1200 e) 1500 Hint: 1% w/v refers to 1 gm (1000 mg) of drug in 100 ml of solution. 8. If a reaction follows third order kinetics, by what factor will the rate of the reaction change when concentration of one of the reactants is doubled? a) 2 b) 3 c) 4 d) 8 e) 12 Hint: Kinetics, third order formula.

9. A pharmacist has 1 lb of 5% w/w drug in ointment form. How many grams of powdered drug must be added to obtain a 20% w/w strength. a) 25.00 b) 36.78 c) 45.50 d) 78.35 e) 85.12 Hint: Alligation method, 1 lb = 454 gm 10. If 250 g of a drug is dissolved in 1000 mL of glycerin (density of glycerin being 1.25 g/mL), the concentration of the drug in the solution is: a) 25.0% w/w b) 20.0% w/w c) 12.5% w/w d) 10.5% w/w e) 10.0% w/w Hint: Weight of 1000 ml glycerin = 1.25 x 1000 = 1250 gm 11. How many milliequivalents of K+ are in 2.5 milliliters of 10% w/v KCl solution if molecular weight of KCl is given to be 74.5? a) 3.35 b) 0.39 c) 0.0745 d) 74.5 e) 7.45 Hint: 2.5 milliliters of 10% w/v KCl = 250 mg KCL, one milliequivalent weight of KCl = 74.5 mg 12. What is the prevalence ratio if 27 people in a population of 500 were affected by a disease and only 17 got reported? a) 17/27 b) 17/500 c) 27/500 d) 27/17 e) 500/17 Hint: Prevalence ratio is the ratio of number of people affected to the total population.

13. The AUC of Plasma Concentration vs Time for 100 mg drug administered by IV route is 12 mcg/ml and AUC for 250 mg of same drug administered orally is 15 mcg/ml. What percentage of the drug was absorbed when given orally? a) 25 b) 37.5 c) 50 d) 63.75 e) 72 Hint: Proportionately, 250 mg of the drug when administered IV will give AUC of 30 mcg/ml compared to 15 mcg/ml achieved orally. 14. Given that T1/2 is 2 hours, how long will it take for 75% of the drug to be eliminated? a) 2 hours b) 4 hours c) 8 hours d) 12 hours e) 16 hours Hint: 75% of any drug will be eliminated in 2 half life period. 15. The dose of a drug is 0.25 mg/Kg. Approximately, what dose should be given to a 6 years old child who weighs 42 Pounds? a) 10.5 mg b) 0.4 mg c) 4.7 mg d) 0.3 mg e) 3.6 mg Hint: 42 lb = 19.06 Kg 16. How many milliliters of a 20% KCl (Mol Wt = 74.5) solution contains 100 mEq of K+ ? a) 0.03725 b) 37.25 c) 0.0745 d) 74.50 e) 35.50 Hint: 100 mEq of potassium is present in 7450 mg of KCl, 20% KCl is 20gm of KCl per 100 ml of solution

17. An item is reduced in price by 10% and the number of units sold has increased by 15%, what is the coefficient of elasticity? a) 1.5 b) 1.0 c) 5.0 d) 25.0 e) 2.5 Hint: Coefficient of elasticity = Change in sales/Change in price 18. Given that T1/2 of a drug is 120 minutes, how long will it take to degrade 90% of the drug? a) 375 minutes b) 377 minutes c) 398 minutes d) 401 minutes e) 403 minutes Hint: k = 0.693/T1/2, T = 2.3 (log Co/C)/k 19. Calculate the "turn over rate" of a pharmacy given that Total Sales: $1,000,000 Profit Margin: 25% Average Inventory: $90,000 a) 15.55 b) 13.22 c) 11.11 d) 9.77 e) 8.88 Hint: TOR = Total Cost of Goods/Average Inventory 20. Find the value of mOsmols of Dextrose in one liter of D5W. (Molecular Weight of Dextrose: 180) a) 1.2 b) 180 c) 277.7 d) 533.3 e) 833.3 Hint: For non-electrolytes, 1 milliosmole is represented by 1 millimole.

21. If 20 ml of a 10% stock solution is diluted to 500 ml, what will be the final concentration? a) 0.01% b) 0.05% c) 0.2% d) 0.25% e) 0.4% Hint: Concentration of a solution is inversely proportional to the dilution factor which in this case is 500/20 = 25 22. How many milliliters of water is required to make an isotonic solution using 9 tablets of NaCl, 250mg? a) 100 b) 250 c) 300 d) 750 e) 900 Hint: Isotonic solution is equivalent to 0.9% NaCl. 23. How many milliliters of diluent is needed to compound 480 ml of theophylline 80 mg/10ml from a stock solution of theophylline 160 mg/15ml? a) 80 b) 100 c) 120 d) 160 e) 180 Hint: Total amount of theophylline required: 480 x 80/10 mg, milliliters of diluent required = 480 - (milliliters of stock solution used) 24. A 170 pound patient receives 1.2 g/kg/day of protein. Approximately, how many protein calories does he receive in 24 hours? a) 370 b) 816 c) 1836 d) 204 e) 93 Hint: 170 lb = 77.18 kg, 1gm of protein provides 4 calories.

25. If a drug has a pKa valueof 5.5 and the pH of a patient's urine is 7.5, what will be the ratio of dissociated to undissociated drug? a) 100 : 1 b) 1 : 100 c) 2 : 1 d) 1 : 2 e) Drug will remain undissociated Hint: pH = pKa + log salt/acid, log 100/1 = 2 26. A prescription read: amethocaine 0.5% mixed with q.s. Dextrose to form 25 ml of isotonic solution (given that NaCl equivalent of amethocaine is 0.19 and that of dextrose is 0.18). How many grams of anhydrous dextrose is required to prepare the prescription? a) 2.24 b) 4.48 c) 1.12 d) 0.56 e) 0.28 Hint: NaCl equivalent represents amount of NaCl that is equivalent to the amount of the substance in consideration, 25 ml of isotonic solution must contain NaCl equivalent of 0.225 gm of both ingredients in question. 27. Expressing the concentration of 0.1% in parts per million will produce a value of: a) 1 ppm b) 10 ppm c) 100 ppm d) 1000 ppm e) 2 ppm Hint: 1 million = 1,000,000 & 0.1% = 0.1 parts per 100 28. A 50 ml of stock solution contains 8 mg of active drug. How many milliliters of this solution must be injected to provide a patient with 400 mcg of active drug? a) 5.00 b) 7.50 c) 0.63 d) 1.25 e) 2.50 Hint: 400 mcg = 0.4 mg, 0.4 mg of active drug is present in (50/8) x 0.4 ml of stock solution.

29. How many milliliters of IV solution should be infused per minute in order to provide the patient with 600 units of Heparin per hour if the IV bag contains 5000 units of Heparin in 500 ml of D5W? a) 1 b) 6 c) 10 d) 60 e) 12 Hint: 600 units/hour provides 600/60 = 10 units/minute, 5000 units/500 ml is 5000/500 = 10 units/ml. 30. If the pKa of a drug is 7.4, approximately what fraction of the drug would be ionized at pH 8.4? a) 5% b) 10% c) 50% d) 90% e) 100% Hint: Hint: pH = pKa + log salt/acid 31. A prescription calls for an order for an IV infusion rate of 30 ml/hour. If the IV tubing has a calibration of 20 drops/ml, what must be the rate of flow? a) 5 drops/minute b) 10 drops/minute c) 15 drops/minute d) 20 drops/minute e) 30 drops/minute Hint: 30 ml/hour = 30 ml/60 minutes = 0.5 ml/minute 32. Approximately how many millimoles of potassium are present in 1 gm of potassium chloride? (Molecular Weight of KCl: 74.5) a) 13.4 b) 26.8 c) 39.0 d) 37.2 e) 74.5 Hint: 1 millimole of potassium is present in 74.5 mg KCl.

33. How much of a liquid drug is present in 4000 ml of a 1:5000 solution? a) 0.2 ml b) 0.4 ml c) 0.5 ml d) 0.6 ml e) 0.8 ml Hint: Ratio & Proportion method. 34. How many milliliters of a 3 mEq/ml solution of sodium chloride is required to prepare 1000 ml of TPN solution specifying 60 mEq sodium chloride? a) 10 ml b) 20 ml c) 30 ml d) 50 ml e) 60 ml Hint: 3 mEq of sodium chloride is present in one milliliter of solution, 60 mEq will be present in 60/3 ml solution. 35. In order to prepare a 1:9000 solution from 25 cc of a 1:300 solution, the pharmacist should add how many milliliters of diluent? a) 8700 b) 7500 c) 750 d) 725 e) 650 Hint: Dilution factor = 9000/300 = 30, final volume = 25 x 30 = 750 (725 + 25) 36. A 25 year old female weighing 120 pound has a creatinine clearance rate of 115 ml/min. What is the serum creatinine concentration for this patient? a) 0.50 mg/dl b) 0.64 mg/dl c) 0.75 mg/dl d) 1.30 mg/dl e) 1.50 mg/dl Hint: Cockroft and Gault equation, female patient will have value of 0.85 of the value calculated for males.

37. A 140 pound female patient receives an IV dose of 750 mg of a drug with Cmax of 20 mcg/ml. What is the apparent volume of distribution? a) 17500 ml b) 27500 ml c) 37500 ml d) 57500 ml e) 60000 ml Hint: 750 mg = 750000 mcg, Vd = IV Dose/Cmax 38. A 150 pound male patient has renal clearance rate of 21.7 liters/hour for a drug and volume of distribution of 1.4 liters/kg. What is the elimination rate constant of this drug? a) 0.10 b) 0.14 c) 0.17 d) 0.22 e) 15.5 Hint: Elimination rate constant = Renal clearance/Volume of distribution 39. How many milliequivalents of sodium will a patient receive per day from the infusion of D5W 1/2NS at the rate of 130 ml/hr? (Mol. Wt. of NaCl = 58.5) a) 0.58 b) 184.6 c) 240.0 d) 369.2 e) 480.0 Hint: 1/2NS = 1/2 (0.9% NaCl) = 0.45% NaCl, calculate the value for 24 hours. 40. A prescription calls for 10 mg/kg/dose for a child weighing 40 pounds to be administered for 20 doses. How many milligrams of the drug is required to prepare the prescription? a) 182 b) 400 c) 6374 d) 1816 e) 3632 Hint: One pound = 0.484 kg