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  • Phases of Drug Metabolism

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    Enzymes involved in the phase 1 and phase 2 metabolism of xenobiotics include cytochrome P450s, flavin-containing monooxygenases, epoxide hydrolases, sulfotransferases, UDP-glucuronosyltransferases, glutathione-S-transferases, N-acetyltransferases, methyltransferases, alcohol dehydrogenases, aldehyde dehydrogenases, and NADPH-quinone oxidoreductase, which catalyze reactions such as oxidation, hydrolysis, sulfate, glucuronide, and glutathione conjugation, acetylation, methylation, and reductions.

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    Enzymes involved in the phase 1 and phase 2 metabolism of xenobiotics include cytochrome P450s, flavin-containing monooxygenases, epoxide hydrolases, sulfotransferases, UDP-glucuronosyltransferases, glutathione-S-transferases, N-acetyltransferases, methyltransferases, alcohol dehydrogenases, aldehyde dehydrogenases, and NADPH-quinone oxidoreductase, which catalyze reactions such as oxidation, hydrolysis, sulfate, glucuronide, and glutathione conjugation, acetylation, methylation, and reductions.

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    5 views1 page

    Phases of Drug Metabolism

    Uploaded by

    kvnptrck11
    Enzymes involved in the phase 1 and phase 2 metabolism of xenobiotics include cytochrome P450s, flavin-containing monooxygenases, epoxide hydrolases, sulfotransferases, UDP-glucuronosyltransferases, glutathione-S-transferases, N-acetyltransferases, methyltransferases, alcohol dehydrogenases, aldehyde dehydrogenases, and NADPH-quinone oxidoreductase, which catalyze reactions such as oxidation, hydrolysis, sulfate, glucuronide, and glutathione conjugation, acetylation, methylation, and reductions.

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    Enzymes Phase 1 "oxygenases" Cytochrome P450s (P450 or CYP) Flavin-containing monooxygenases (FMO) Epoxide hydrolases (mEH, sEH) Phase

    2 "transferases" Sulfotransferases (SULT) UDP-glucuronosyltransferases (UGT) Glutathione-S-transferases (GST) N-acetyltransferases (NAT) Methyltransferases (MT) Other Enzymes Alcohol dehydrogenases Aldehyde dehydrogenases NADPH-quinone oxidoreductase (NQO)

    Reactions C and O oxidation, dealkylation, others N, S, and P oxidation Hydrolysis of epoxides

    Addition of sulfate Addition of glucuronic acid Addition of glutathione Addition of acetyl group Addition of methyl group

    Reduction of alcohols Reduction of aldehydes Reduction of quinones

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