DRUG STUDY

DATE ORDERE D

GENERIC NAME (BRAND NAME) Piperacillin sodium and tazobactam sodium

CLASSIFIC ATION

DOSAG E

MECHANIS M OF ACTION

INDICATIO NS

CONTRAINDICA TIONS

SIDE EFFECTS/ ADVERSE EFFECTS

NURSING IMPLICATIONS RESPONSIBILITIES 1. Administer medication via IVTT. 2. Position client in high fowlers upon administration of medication to prevent aspiration. 3. Check the placement of NGT. 4. Assess and ask client or SO about previous allergic reactions to penicillins. 5. Monitor for any adverse reactions. 6. Ensure right amount of dose is given.

July 22, 2012

Penicillin Antibiotic

4.45gm IVTT q 8

Piperacillin inhibits cell wall synthesis during microorganis m multiplication ; tazobactam increases piperacillin effectiveness by inactivating betalactamase which destroys penicillins.

Moderate to severe nosocomial pneumonia caused by piperacillinresistant.

Patients hypersensitive to the drug or other penicillin. Use cautiously in patients with other drug allergies, especially to cephalosporin and in those with bleeding tendencies, uremia or hypokalemia.

CNS: pain, headache, insomnia, agitation, fever, dizziness, anxiety. CV: hypertension, tachycardia, chest pain, edema GI: diarrhea, nausea, constipation, vomiting, dyspepsia, stool changes, abdominal pain. Hematologic: thrombocytopenia Respiratory: dyspnea