The immune system has evolved to protect animals from invading pathogenic microorganisms and cancer. An immune response can be divided into two related activities--recognition and response. Immune recognition is remarkable for its specificity. Later exposure to the same foreign organism induces a memory response.
The immune system has evolved to protect animals from invading pathogenic microorganisms and cancer. An immune response can be divided into two related activities--recognition and response. Immune recognition is remarkable for its specificity. Later exposure to the same foreign organism induces a memory response.
The immune system has evolved to protect animals from invading pathogenic microorganisms and cancer. An immune response can be divided into two related activities--recognition and response. Immune recognition is remarkable for its specificity. Later exposure to the same foreign organism induces a memory response.
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Overview of the Immune System chapter 1
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defense system that has evolved to protect animals from invading pathogenic microorganisms and cancer. It is able to generate an enormous variety of cells and molecules capable of specifically recognizing and eliminat- ing an apparently limitless variety of foreign invaders. These cells and molecules act together in a dynamic network whose complexity rivals that of the nervous system. Functionally, an immune response can be divided into Numerous T Lymphocytes Interacting with a Single two related activities—recognition and response. Immune Macrophage recognition is remarkable for its specificity. The immune system is able to recognize subtle chemical differences that distinguish one foreign pathogen from another. Further- ■ Historical Perspective more, the system is able to discriminate between foreign ■ Innate Immunity molecules and the body’s own cells and proteins. Once a for- eign organism has been recognized, the immune system ■ Adaptive Immunity recruits a variety of cells and molecules to mount an appro- ■ Comparative Immunity priate response, called an effector response, to eliminate or neutralize the organism. In this way the system is able to ■ Immune Dysfunction and Its Consequences convert the initial recognition event into a variety of effector responses, each uniquely suited for eliminating a particular type of pathogen. Later exposure to the same foreign organ- ism induces a memory response, characterized by a more rapid and heightened immune reaction that serves to elimi- Like the later chapters covering basic topics in immu- nate the pathogen and prevent disease. nology, this one includes a section called “Clinical Focus” This chapter introduces the study of immunology from that describes human disease and its relation to immunity. an historical perspective and presents a broad overview of These sections investigate the causes, consequences, or treat- the cells and molecules that compose the immune system, ments of diseases rooted in impaired or hyperactive immune along with the mechanisms they use to protect the body function. against foreign invaders. Evidence for the presence of very simple immune systems in certain invertebrate organisms then gives an evolutionary perspective on the mammalian immune system, which is the major subject of this book. El- Historical Perspective ements of the primitive immune system persist in verte- The discipline of immunology grew out of the observation brates as innate immunity along with a more highly evolved that individuals who had recovered from certain infectious system of specific responses termed adaptive immunity. diseases were thereafter protected from the disease. The These two systems work in concert to provide a high degree Latin term immunis, meaning “exempt,” is the source of the of protection for vertebrate species. Finally, in some circum- English word immunity, meaning the state of protection stances, the immune system fails to act as protector because from infectious disease. of some deficiency in its components; at other times, it be- Perhaps the earliest written reference to the phenomenon comes an aggressor and turns its awesome powers against its of immunity can be traced back to Thucydides, the great his- own host. In this introductory chapter, our description of torian of the Peloponnesian War. In describing a plague in immunity is simplified to reveal the essential structures and Athens, he wrote in 430 BC that only those who had recov- function of the immune system. Substantive discussions, ex- ered from the plague could nurse the sick because they perimental approaches, and in-depth definitions are left to would not contract the disease a second time. Although early the chapters that follow. societies recognized the phenomenon of immunity, almost