IGF-1 DES Synthesis or Circulation

Posted on May 9, 2014 by Maxim Peptide

IGF-1 DES refers to a cleaved version of the common peptide insulin-like groth factor 1! "his is a truncated
version of the peptide hich includes soamtomedin C! Studies have found that this peptide is around 1# times more
potent and functional than standard IGF-1 in regards to stimulating the proliferation of cells that have $een cultured
as ell as stimulating hypertrophy! IGF-1 DES is also found to $e more potent $ecause this version of the peptide
has removed glutamate from amino acid position %!
&atural insulin-like groth factor 1 may $e referred to interchangea$ly as somatomedin C depending on the
application! "his is a protein hich humans have encoded $y an animal's $ody using the IGF gene! "his is also
knon naturally as the sulfation factor hich causes effects( something that the scientific community has deemed
nonsuppressi$le insulin-like activity!
Synthesis or Circulation
IGF-1 is naturally produced in an animal's liver( though there are some alternative sources for this peptide( hich is
used as an endocrine hormone hich ill target tissues in the autocrine or paracrine system!
"he production of IGF-1 is stimulated $y the presence of groth hormone hich is retarded hen the animal is
lacking the appropriate nutrition for ideal functionality!
Groth hormone sensitivity or a lack of receptors for groth hormone as ell as a failure of the signaling
pathay donstream from these pathays can cause the animal's $ody to fail to produce an ade)uate amount
of IGF! "he production and administration of IGF-1 DES is largely designed to address the needs of animals
that have these conditions ith potential human application if research is successful!
*round +, percent of IGF-1 is designed to $ind ith one of - proteins! "he most common of these is IGF./-%
hich accounts for around ,# percent of all IGF $inding ith in an animal's system!
In rats it has $een found that IGF-1 in the m0&* found ithin the liver can $e positively associated ith dietary
casein as ell as $eing negatively associated ith a diet that is lacking in protein! 1ore recent research has found
that the e2pression of plants in a system can $e used to create a $iologically active recum$ent human version of
IGF-1( knon as rhIGF-1 in transgenic grains of rice!
1echanisms of *ction
"he primary actions of IGF-1 and synthetic versions( including IGF-1 DES( is to $ind to specific receptors(
specifically IGF10 hich is present in a variety of cell types that helps to make up a variety of different types of
tissue!
.inding ith IGF10 creates a tyrosine kinase hich ill help the $ody to initiate intracellular signaling! "he
natural version of IGF-1 is considered to $e the most potent natural activators ithin the signaling pathay
3*4"5! "his helps to signal proliferation as ell as cell groth( and in certain cases cell death!
IGF-1 is one of the primary mediators on the effects that groth hormone ill have on an animal! Groth
hormone is produced ithin the anterior pituitary gland hich ill then release this chemical into the $lood
stream and stimulate the liver to produce the necessary amount of IGF-1 that ill stimulate most cells in the
$ody to gro!
If these pathays are not functioning properly( scientists are hoping to stimulate specific areas of the $ody as
necessary using synthesi6ed or hyper-potent versions of these chemicals such as IGF-1 DES to get the
necessary results!
IGF-1 as ell as other tyrosine kinase groth factor receptors are used through signal pathays! * key of the
pathay is regulated using /1%4 to move through the donstream current through the $ody! "hose that are
deficient in these chemicals are considered to $e recom$inant and often categori6ed as having 7aron syndrome!
"his is particularly common in $eef cattle!
Synthesi6ing IGF-1 DES can $e done ith a variety of chemical processes! "his ill help the chemical take on the
specific properties necessary for a given application ithin an animal! "his peptide is $oth created $y truncating a
standard IGF molecule structure and $y replacing some of the e2isting amino acids or eliminating them all together
in order to create a more sta$le molecule hich has a longer half-life and is capa$le of reaching other tissues ithin
the $ody!
Given the specific nature of this peptide it is important to perform careful research hen looking for la$oratory
supplies in order to get a peptide that ill create the anticipated results!
0esource .o28
http899en!ikipedia!org9iki9Insulin-like:groth:factor:1
http899!ma2impeptide!com9igf-1-des-1-mg9