Course

Duration
Purpose

COURSE
DESCRIPTION
1)
Innate &
Acquire
d
Immunit
y

2)
Cellular
Basis of
Immune
Respons
e

The class presents basic features of

Immune system and its types
Cellular basis of immune response
Antibodies
Humoral immunity
Hypersensitivity
MHC and transplantation
Autoimmune diseases
AIDs / HIV (reterovirus) Immunodeficiency.

I.
II.

Function of immune system

Table 57-1
Table 57-2
Table 57-3
III.
Cell mediated immunity
Bacteria (MHC II) ( IL -2 , gama
interferon)
Virus (MHC I) (IL-2)
IV.
Antibody mediated immunity
(MHC II) (IL 2,4,5)
B cell -> Plasma Cells -> antibodies.
T-cell independent antigens ( IgM )
V.
Receptors
TLR
MBL
NOD
TLR
RIG-1 Helicase.
VI.
Adaptive Immunity
NOD
(figure 57-4)
VII.
Antigen
RIG-1
MBL
VIII.
Hapten ( conjugate vaccine)
hehelicas
ORIGIN OF IMMUNE RESPONSE
i.
CD4 CD8 - - (Double negative)
Cortex
ii.
CD4 CD8 ++ (Double positive)
iii.
CD4 CD8 (Either) -------------Medulla
Table 58-2
Table 58-3
Table 58-4
Table 58-5
Table 58-6
Table 58-7
T Cells

thymus

3)
Antibodi
es
4)
Humoral
immunit
y

5) MHC
and
Transpla
ntation
6)
Comple
ment
7)
Hpersen
sitivity

CD4 & CD8 TYPES

o CD4
Th 1 IL-2
Th-2 IL-4,5
Th-17 IL-17
Thymic education
Positive selection
Negative selection
Memory cells
4 features pg 482
Superantigens
NKC
Functions of
Neutrophils
Eosinophils
Basophils & mast cells.

Structure (important)
Functions of antibodies (GAMED)
table pg 497 + pg 504
Figures pg 498 & 496
Figures 60-1 for understanding
Construct table to diff b/w primary & secondary immune
response
PRIMARY:
Longer lag period (7 -10 days)
Small clone of Bcells & plasma cells formed
IgM (appear first)
IgM followed by IgG or IgA
SECONDARY:
Rapid (3-5 days)
Memory cells
Large amount of IgG.

Table 62-1
Autograft, syngeneic graft , xenograft , allograft.
Graft versus host reaction
Why fetus is not rejected?
Biologic effects of complement pg 516
Coombs Test pg 523.
Table 62-1 (imp)
Important mediators of type 1 reaction.
Type 3

 Arthus reaction
Serum sickness
Immune complex diseases
Glomerulonephritis & Rh.arthritis ( from special
bacterio pg 121)
SLE
Type 4 table pg 534.
8)
Autoim
mune
diseases
9) AIDS/
HIV
reterovi
rus

Table 66-1 (diseases involve one cell / oragan / system

Names of diseases only

BOOK

CHAPTER 45
Reterovirus , SS linear , RNA virus , 2 identical strands
(diploid)
Positive polarity, Enveloped , icosahedral.
Important properties of virus (brief)
Transmission
Pathogenesis (detail)
Clinical findings
Early , acute stage
Middle , latent stage
Late, immunodeficiency stage.
Lab diagnosis (points)
Prevention (brief)
LEVINSON
Chapters 57-68
Chapter 45 (for AIDS / HIV)