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  • Relative Potency of Vasopressors and Inotropes for Different Receptors

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    Rolando Juan Dávila Salcedo
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    The table shows the relative receptor potency of various vasopressor and inotropic agents at different receptor types. It finds that dobutamine, dopamine, epinephrine, and norepinephrine have varying degrees of affinity for alpha-1, beta-1, and beta-2 receptors, while phenylephrine is highly selective for alpha-1 receptors and vasopressin is highly selective for vasopressin-1 receptors. The document examines the physiology and clinical use of these drugs in cardiovascular disease.

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    USO RACIONAL DE VASOACTIVOS, INOTROPICOS, INODILATADORES

    Original Title

    Tabla Accion Vasoactivos

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    The table shows the relative receptor potency of various vasopressor and inotropic agents at different receptor types. It finds that dobutamine, dopamine, epinephrine, and norepinephrine have varying degrees of affinity for alpha-1, beta-1, and beta-2 receptors, while phenylephrine is highly selective for alpha-1 receptors and vasopressin is highly selective for vasopressin-1 receptors. The document examines the physiology and clinical use of these drugs in cardiovascular disease.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    4 views1 page

    Relative Potency of Vasopressors and Inotropes for Different Receptors

    Uploaded by

    Rolando Juan Dávila Salcedo
    The table shows the relative receptor potency of various vasopressor and inotropic agents at different receptor types. It finds that dobutamine, dopamine, epinephrine, and norepinephrine have varying degrees of affinity for alpha-1, beta-1, and beta-2 receptors, while phenylephrine is highly selective for alpha-1 receptors and vasopressin is highly selective for vasopressin-1 receptors. The document examines the physiology and clinical use of these drugs in cardiovascular disease.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Table 1

    Relative Receptor Potency3


    Agent
    Dobutamine
    Dopamine
    Epinephrine
    Milrinone
    Norepinephrine
    Phenylephrine
    Vasopressin

    Alpha-1
    +
    +++
    +++++
    0
    +++++
    +++++
    0

    Beta-1
    +++++
    ++++
    ++++
    0
    +++
    0
    0

    Beta-2
    +++
    ++
    +++
    0
    ++
    0
    0

    Dopamine
    0
    +++++
    0
    0
    0
    0
    0

    Vasopressin-1
    0
    0
    0
    0
    0
    0
    +++++

    0 = no significant receptor affinity; + through +++++ = minimal to maximal receptor


    affinity

    3. Overgaard CB, Dzavik V. Inotropes and vasopressors: review of physiology


    and clinical use in cardiovascular disease. Circulation. 2008;118:10471056.
    [PubMed]

    Pollard S, Edwin SB, Alaniz C. Vasopressor and Inotropic Management Of Patients


    With Septic Shock. Pharmacy and Therapeutics. 2015;40(7):438-450.

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