THVLPFEKINEGFDLLRSGESI

Side chain
Amino
group

Carboxyl
group

zwitterionic

Polar

Aliphatic
A

Charged
M

I
D

Aromatic
Conformationally
unique
W

Chemically
unique
C

Aspartate

Glutamate

Asp
3.9
C-terminus
2.0

Glu
4.3

Mostly deprotonated at
pH 7.4

His
6.0

N-terminus
9.0
Tyr
10.1
Cys
Lys
8.3
10.5

Thr/Ser
13.0
Arg
12.5

Mostly protonated at
pH 7.4

Methionine

Cysteine

Leucine

Oxidation

Reduction

Glycine

Proline

Non-polar

tiny
P

CS-S

aliphatic

V
L

small

G
CH T S N

D

Y
K E
F
H
W R

polar

aromatic
positive
charged

Non-polar

tiny
P

CS-S

aliphatic

V
L

small

G
CH T S N

D

K E
Y
F
H
W R

polar

aromatic
positive
charged

Non-polar

tiny
P

CS-S

aliphatic

V
L

small

G
CH T S N

D

K E
Y
F
H
W R

polar

aromatic
positive
charged

THVLPFEKINEGFDLLRSGESI

Primary

Quaternary

Secondary

Tertiary

THVLPFEKINEGFDLLRSGESI

Primary

Secondary

Image credits:

All molecular structures were created from copyright-free PDB files available at www.pdb.org.
The PDB identifier of each file, and the original reference, are provided here for scholarly
purposes.

Alcohol dehydrogenase: PDB ID 1ADC

Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, et al. (1994) Crystallographic
studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate
binding in two ternary complexes. Biochemistry 33: 1173411744.


Hen egg lysozyme: PDB ID 2LYZ

Diamond R (1974) Real-space refinement of the structure of hen egg-white lysozyme. J Mol
Biol 82: 371391.