Protein Protein Interactions

Sai Krishna
Department of Computer Science
IIT Kanpur

October 27, 2016

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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What are proteins?

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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DNA to Protein

Figure: DNA to proteins

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Why are proteins important?

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Why are proteins important?

Control vital body functions including release of hormones, transporting

molecules, responding to stimuli etc.

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Pathogen Host Interactions

Pathogen enters host body

Pathogen injects proteins and genetic material into host cells.

These proteins interact with other proteins and disrupt the normal
functioning of the cell.

Host gets the disease.

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Why prediction is important

40k X 4k = 160M
Only 68 pairs are known to interact.

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Outline
1

Pathogen Host Interactions

Why prediction is important?

Take aways

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Take aways

What are proteins

Why proteins are important
How a pathogen attacks a host
Why predicting PPI is important.

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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Questions?

Sai Krishna (IIT Kanpur)

Protein Protein Interactions

October 27, 2016

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