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    Paget's disease causes bones to enlarge and weaken. About one million people in the US have Paget's disease, which is caused by genetic mutations. Symptoms include enlarged bones, broken bones, and damaged joints. The karyotype in one Paget's patient was 47,XYY. Genetics research has identified mutations in the TNFRSF11B and SQSTM1 genes as common causes. Treatment involves orthopedic surgeons, neurologists, and otolaryngologists to manage symptoms and repair bone damage.

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    Paget's disease causes bones to enlarge and weaken. About one million people in the US have Paget's disease, which is caused by genetic mutations. Symptoms include enlarged bones, broken bones, and damaged joints. The karyotype in one Paget's patient was 47,XYY. Genetics research has identified mutations in the TNFRSF11B and SQSTM1 genes as common causes. Treatment involves orthopedic surgeons, neurologists, and otolaryngologists to manage symptoms and repair bone damage.

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    36 views1 page

    Pagentsdisease

    Uploaded by

    api-340838836
    Paget's disease causes bones to enlarge and weaken. About one million people in the US have Paget's disease, which is caused by genetic mutations. Symptoms include enlarged bones, broken bones, and damaged joints. The karyotype in one Paget's patient was 47,XYY. Genetics research has identified mutations in the TNFRSF11B and SQSTM1 genes as common causes. Treatment involves orthopedic surgeons, neurologists, and otolaryngologists to manage symptoms and repair bone damage.

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    of 1

    Pagets Disease

    What is Pagets Disease


    Pagets disease causes bones to
    grow too large and weak.
    Symptoms of Pagets disease:
    Enlarged bones
    Easily broken bones
    Damaged cartilage in
    joints.

    Nate Poris
    Period 7

    Karyotype of Pagets
    Disease
    The karyotype is 47 xyy in a
    patient with pagets disease.

    About one million people in the


    United States have Paget's
    disease.
    Genetics: It is a gene disorder, it
    is Dominant and x- it is located
    on the chromosome 18q and on
    the gene TNFRSF11A. Pagets
    disease is caused by mutations
    in the TNFRSF11B gene.
    Cell Biology and DNA for
    Pagets Disease:

    Mutations SQSTM1,
    TNFRSF11A, TNFRSF11B,
    SQSTM1 gene are the most
    common genetic cause of
    Paget disease of the bone.

    Citations:

    "Questions and Answers about


    Paget's Disease of Bone." Questions
    and Answers about Paget's Disease
    of Bone. N.p., n.d. Web. 03 Feb.
    2014.
    "Paget's Disease of Bone-OrthoInfo AAOS." Paget's Disease of BoneOrthoInfo - AAOS. N.p., n.d. Web. 03
    Feb. 2014.
    "Paget Disease of Bone." - Genetics
    Home Reference. N.p., n.d. Web. 03
    Feb. 2014.
    "Paget Disease ." Paget Disease.
    N.p., n.d. Web. 01 Feb. 2014.
    N.p., n.d. Web.

    Lifestyle of Pagets disease:


    If you have Pagents disease these
    doctors can help you become cured.

    How to know if you have


    Pagets disease:
    Spine: Curved spine, back
    pain, or damage to nerves
    causing problems such as
    tingling and numbness.
    Leg: Bowed legs, pain, or
    arthritis in the hip and knee
    joints.
    Pelvis: Pain or arthritis in the
    hip joint.
    Skull: Enlarged head, hearing

    Pagents disease expands the


    the cell to a very extreme
    extent.

    Orthopaedic surgeons: who


    specialize in diagnosing,
    treating, and preventing injuries
    and disorders of the
    musculoskeletal system, which
    includes bones, joints,
    ligaments, muscles, nerves, and
    tendons.
    Neurologists: who are trained to
    diagnose and treat disorders of
    the nervous system, which
    includes the brain, spinal cord,
    nerves, and muscles.
    Otolaryngologists: who
    specialize in conditions of the
    ear, nose, and throat.
    Pagents disease give you pains
    where it has affected you, the
    goal of the treatment is to help
    repair your bones, it can be lived
    with but if not treated it will
    become serious.

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