Professional Documents
Culture Documents
2011 2013
Submitted by
Guided by
This is to certify that Manish Ranjan Singh, son of Dr. Satyendra Narayan Singh Pursuing
MBA from Institute of Management and Entrepreneurship Development, Pune has
successfully completed the Project Report in our organization on the topic titled,
Marketing Research for New Product Launch: Cisatracurium from 1st June to 10th
August 2012. During his project tenure in the organization/company, we found him hard
working, sincere and diligent person and his behavior and conduct was good. We wish him all
the best for his future endeavors.
Signature
Sandeep Pawar (Group Product Manager)
Name and Designation of the Guide
2|Page
Certificate of Originality
This is to certify that the project report entitled Marketing Research for New Product
Launch: Cisatracurium Submitted to Bharati Vidyapeeth Deemed University, Pune in
partial fulfillment of the requirement for the award of the degree of MBA (Finance &
Marketing) is an original work carried out by Mr. Manish Ranjan Singh, under the guidance
of Ms. Ranpreet Kaur. The matter embodied in this project is a genuine work done by
Manish Ranjan Singh to the best of my knowledge and belief and has not been submitted
before, neither to this University nor to any other University for the fulfillment of the
requirement of any course of study.
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Certificate
This is to certify that the project titled Marketing Research for New Product Launch:
Cisatracurium is an academic work done by Manish Ranjan Singh submitted in the
partial fulfillment of the requirement for the award of the Degree of MBA (Finance &
Marketing) from Bharati Vidyapeeth Deemed University, Pune. It has been completed under
the guidance of Ms. Ranpreet Kaur (Faculty Guide) and Mr. Sandeep Pawar (Corporate
Mentor). We are thankful to Abbott India Ltd. for having allowed our student to undergo
project work training. The authenticity of the project work will be examined by the viva
examiner which includes data verification, checking duplicity of information etc. and it may
be rejected due to non fulfillment of quality standards set by the Institute.
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ACKNOWLEDGEMENT
The satiation and euphoria that accompany the successful completion of the project would be
incomplete without the mention of the people who made it possible.
I would like to take the opportunity to thank and express my deep sense of gratitude to my
corporate mentor Mr. Sandeep Pawar and my faculty mentor Ms. Ranpreet Kaur. I am greatly
indebted to both of them for providing their valuable guidance at all stages of the study, their
advice, constructive suggestions, positive and supportive attitude and continuous
encouragement, without which it would have not been possible to complete the project.
I would also like to thank Mr. Rajesh Pandey (Country Manager) who in spite of busy
schedule has co-operated with me continuously and indeed, his valuable contribution and
guidance have been certainly indispensable for my project work.
I am thankful to Mr. Sandeep Pawar for giving me the opportunity to work with Abbott India
Ltd. and learn.
I owe my wholehearted thanks and appreciation to the entire staff of the company for their
cooperation and assistance during the course of my project.
I hope that I can build upon the experience and knowledge that I have gained and make a
valuable contribution towards this industry in coming future.
Signature
5|Page
Preface
The objective of the project was to understand the Neuro Muscular Blocker (NMB) market
& develop the medical positioning for Cisatracurium for Abbott India Ltd., for that we have
to understand the customer needs (doctors), pricing constraints, response, emotions and
beliefs regarding the product, so that they can contribute their valuable inputs for introducing
the Cisatracurium in India for the company. The objective of this study was to analyze the
clinical practice of the available neuromuscular blocker in Mumbai and Pune city with respect
to the survey in the best hospitals of the city.
The project was started on 1st of June after knowing all the relevant information regarding the
project, under the guidance of Mr. Sandeep Pawar (Group Product Manager). The first part of
my project involves the study of the Anesthetists armamentarium of drugs, Understand the
NMB category & their mechanism of action and Clinical use of NMBs & their place in
therapy. For this I used Internet as a primary source of information for study, also attended a
day with Dr. Amit Arora discussing the topics. Along with the detailed study of NMB
category the study was more focused on Cisatracurium.
Since, the next part of my project was to develop the questionnaire respected to medical
positioning for Cisatracurium and clinical preferences of current NMBs available. Hence, the
detailed study provided me a rough idea in developing questionnaire and my corporate mentor
guided me in finalizing the questionnaire. For this the questionnaire was prepared which gave
the vague idea about the customers, who were really interested in practicing the new molecule
and wanted to know about the availability of the molecule in the country. Go through
questionnaire in different hospitals and people in the Pune and Mumbai city. The marketing
research was undertaken for Pune and Mumbai region during one month. The sample size of
the marketing research was taken to be 40. The questionnaire contains various aspects like
their Name, Contact Number, E-mail Id, Hospital Name, NMB preference and Cisatracurium
advantage etc. The final part of the project consists of 15 days of scanning the questionnaire.
Most important part is analyzing the information.
Signature
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Index
1. CHAPTER 1: Introduction..9-30
1.1. Overview of the Industry..10
1.1.1. Pharmaceutical Industry in India
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CHAPTER 1
Introduction
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Playing a key role in promoting and sustaining development in the vital field of medicines,
Indian Pharma Industry boasts of quality producers and many units approved by regulatory
authorities in USA and UK. International companies associated with this sector have
stimulated, assisted and spearheaded this dynamic development in the past 53 years and
helped to put India on the pharmaceutical map of the world.
The Indian Pharmaceutical sector is highly fragmented with more than 20,000 registered units
with severe price competition and government price control. It has expanded drastically in the
last two decades. There are about 250 large units that control 70 per cent of the market with
market leader holding nearly 7 per cent of the market share and about 8000 Small Scale Units
together which form the core of the pharmaceutical industry in India (including 5 Central
Public Sector Units). These units produce the complete range of pharmaceutical formulations,
i.e., medicines ready for consumption by patients and about 350 bulk drugs, i.e., chemicals
having therapeutic value and used for production of pharmaceutical formulations.
Following the de-licensing of the pharmaceutical industry, industrial licensing for most of the
drugs and pharmaceutical products has been done away with. Manufacturers are free to
produce any drug duly approved by the Drug Control Authority. Technologically strong and
totally self-reliant, the pharmaceutical industry in India has low costs of production, low R&D
costs, innovative scientific manpower, strength of national laboratories and an increasing
balance of trade.
The number of purely Indian pharma companies is fairly low. Indian pharma industry is
mainly operated as well as controlled by dominant foreign companies having subsidiaries in
India due to availability of cheap labour in India at lowest cost. Most pharma companies
operating in India, even the multinationals, employ Indians almost exclusively from the
lowest ranks to high level management. Mirroring the social structure, firms are very
hierarchical. Homegrown pharmaceuticals, like many other businesses in India, are often a
mix of public and private enterprise. Although many of these companies are publicly owned,
leadership passes from father to son and the founding family holds a majority share.
The total Indian production constitutes about 13 per cent of the world market in value terms
and, 8 per cent in volume terms. The per capita consumption of drugs in India, stands at
US$3, is amongst the lowest in the world, as compared to Japan- US$412, Germany- US$222
and USA- US$191.
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Company Profile
About The Company
Abbott Laboratories is a Chicago-based global, diversified (multi-division)
pharmaceuticals and health care products company. It has 90,000 employees and operates in
over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois.
The company was founded by Chicago physician, Dr. Wallace Calvin Abbott in 1888. In
2011, Abbott had over $38.9 billion in revenue. Abbott Laboratories is one of the major
multinational company in the pharmaceutical industry. Abbott, is a company that focuses on
turning science into caring ABBOTT, A Promise for Life. For more than a century, Abbott
Laboratories has been working to advance health care for people around the world. Founded
in 1888 by a young Chicago physician, Dr Wallace Calvin Abbott, Abbott Laboratories has
evolved into a diversified health care company that discovers, develops, manufactures and
markets innovative products and services. Products and services of Abbott, span the
continuum of care from prevention and diagnosis, to treatment and cure. Abbott today is a
global, diversified health care company devoted to the discovery, development, manufacture
and marketing of pharmaceutical, diagnostic, nutritional and hospital products.
Abbott extends this commitment with a strong presence in India as it has grown and evolved
its operations in India over many decades. The products encircle life from newborns to ageing
adults. Abbott has built expertise and leadership in primary care therapeutic areas like
Gastroenterology and Paincare. Our specialty areas include Neuroscience, Metabolics and
Hospital Care. Abbott serves the needs of Indian consumers with products backed by science
and R&D. It has locally developed brands like Digene, Cremaffin, Epilex, Zolfresh and
Obimet. Abbott has also brought global products including Brufen, Prothiaden, Ganaton,
Sevorane, Thyronorm and Leptos to Indian consumers. Abbotts pioneering products like
Survanta help infants. As of 2010, Abbott India Ltd. tops the list of publicly listed life science
companies in India and the revenue generated in the year 2011 is the highest than any other
pharmaceutical company doing business in the country.
Abbott India, today has strong brand equity and commands esteem in the market place. To
reach the customer, Abbott India has a network of 18 distribution points, which cater to
11,000 stockists and 70,000 retailers. Behind Abbott Indias success, is a team of competent,
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committed people, driven by the principles of Value Based Management, and aided by strong
alliances and partnerships.
Abbott India Limited, provides healthcare solutions through its four business units:
1. Primary Care - which markets products in the areas of Pain Management,
Gastroenterology, with well-known brands like Brufen, Digene, Cremaffin.
2. Specialty Care - Metaboloics & Urology provides solutions in the areas of Thyroid,
Obesity, Diabetes and Benign Prostratic Hyperplasia.
3. Specialty Care - Neuroscience has a varied portfolio, with specialty products in the
Neurology and Psychiatric segments.
4. Hospital Care - offers products in the field of anesthesiology and neonatology namely
Forane, Sevorane and Survanta.
The company has over 1000 employees and a state-of-the-art formulation plant at Verna in
Goa. The manufacturing locations are designed to produce quality, high volume formulations
using cost efficient processes. The plant has well equipped laboratories and trained personnel
to ensure international standards of quality at each step of the manufacturing process.
The company has in-house development and medical teams to undertake product and clinical
development tailored to the needs of the Indian market.
Abbott provides quality health care worldwide by creating healthcare solutions, which directly
affects the life of the common man.
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Primary Businesses
Medical Products Key lines of business include vascular, laboratory and molecular
diagnostics, diabetes care, vision care and animal health.
Nutritionals Abbott offers a variety of nutrition products for infants, children, active
adults and patients with special dietary needs.
Areas of Expertise:
Pharmaceuticals
Medical Products
Nutritional Products
Anesthesia
Animal Health
Pediatric Nutrition
Anti-infectives
Diabetes Care
Healthy Living
Cardiovascular
Diagnostics
Medical Nutrition
Immunology
Hematology
Metabolics
Molecular
Neuroscience
Point of Care
Oncology
Vascular
Pain Care
Renal Care
Virology
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Number of Employees:
2011 Revenue:
$38.9 billion
$4.1 billion
Pharmaceutical
Research Centers:
Countries Where
Products are Sold:
Revenue: $38.9B
Net Income: $4.7B
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Vision
To be the worlds premier health care company
Dedication
To employees, customers, shareholders, suppliers and the public
Strategy
Value Based Management is our integral philosophy, directed towards maximizing long-term
cash flow and shareholder value through:
Focus on the Company's core profitable segments to build up our position as one of
the leading pharmaceutical companies;
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Company History
and codeine),
Early Decades
Abbott Laboratories has its origin in the late 19th century in a small
pharmaceutical operation run from the kitchen of a Chicago physician named Wallace Calvin
Abbott. As did other physicians of the time, Dr. Abbott commonly prescribed morphine,
quinine, strychnine, and codeine--all of which were liquid alkaloid extracts--for his patients.
Because they existed only in a liquid form, these drugs were prone to spoilage over time,
mitigating their effectiveness as treatments. In 1888, Dr. Abbott heard that a Belgian surgeon
18 | P a g e
had developed alkaloids in solid form. Alkaloid pills soon became available in Chicago, but
Dr. Abbott was dissatisfied with their quality, and he decided to manufacture his own.
Dr. Abbott began to advertise his products to other doctors in 1891. So successful was his
business that he eventually sold shares to other doctors and incorporated his operation in 1900
as the Abbott Alkaloidal Company. By 1905, annual sales had grown to $200,000. Ten years
later, the company changed its name to Abbott Laboratories. During World War I, Abbott's
company was essential to the medical community, as several important drugs, manufactured
exclusively by German companies, were no longer available in the United States. Abbott
developed procaine, a substitute for the German novocaine, and barbital, a replacement for
veneral.
After the war, Abbott continued to concentrate on the research and development of new drugs.
In 1921, the company established a laboratory in Rocky Mount, North Carolina, which
developed a number of new drugs, including sedatives, tranquilizers, and vitamins. Even after
Dr. Abbott's death that year, the company continued to invest heavily in new product
development and aggressive marketing campaigns. The company went public in 1929 with a
listing on the Chicago Stock Exchange. Two years later, Abbott expanded outside the United
States for the first time with the establishment of an affiliate in Montreal, Canada.
DeWitt Clough was named president of the company in 1933, ending a period of somewhat
stale communal leadership. A more dynamic character than any since Dr. Abbott, Clough is
best remembered for the inauguration of the company magazine, What's New? The
publication had such a positive impact on worker morale and public opinion that several of
Abbott's competitors started similar publications. In 1936 Abbott began its long-term
association with anesthetics when it introduced sodium pentothal, which had been developed
by Abbott scientists Ernest Volwiler and Donalee Tabern (who in 1986 were named to the
U.S. Inventors Hall of Fame for this discovery).
During World War II, Abbott once again played an important role in battlefield and hospital
healthcare. By this time, American pharmaceutical companies such as Abbott were much less
dependent on Germany's companies, particularly the IG Farben--a conglomeration of the
world's most advanced drug manufacturers. After the war, much of the IG Farben's research
was turned over to American manufacturers. Abbott, however, had little to gain from this
information; it was already a worthy competitor on its own.
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After the departure of DeWitt Clough in 1945, Abbott shifted its attention to the development
of antibiotics. The company developed the antibiotic erythromycin, which, introduced under
the brand names Erythrocin and E.E.S. in 1952, constituted a significant portion of Abbott's
prescription drug sales for several decades--even after the expiration of its 17-year patent.
Sales of the drug increased dramatically when it was found to be an effective treatment for
Legionnaire's disease.
Abbott stumbled onto a lucrative new product when one of its researchers accidentally
discovered that a chemical with which he had been working had a sweet taste. The chemical, a
cyclamate, could be used as an artificial sweetener. Initially, from 1950, it was marketed to
diabetics, but in the 1960s, as Americans became more health and diet conscious, it was
increasingly used as a sugar substitute in a wide variety of foods.
In 1964 Abbott completed the first major acquisition in company history when it purchased
Columbus, Ohio-based M & R Dietetic Laboratories. M & R was the manufacturer of Similac
baby formula and over the succeeding decades, as the company's Ross Products Division,
formed the basis for Abbott's market-leading infant and adult nutritionals business.
several years before they could market their discoveries. Consumer products, on the other
hand, involved more expensive marketing and generated less profit than pharmaceuticals.
Unable to increase profits without substantial risk, Abbott's management decided to maintain
the strategies that were in place.
Cyclamate sales had grown so dramatically that by 1969 they accounted for one-third of
Abbott's consumer product revenues--or about $50 million. The increasing popularity of
cyclamates as an ingredient in diet foods, however, led the Food and Drug Administration
(FDA) to conduct an investigation of possible side effects from their overuse. The FDA's
research was widely criticized as 'fragmentary' and 'fatally flawed,' but it was nonetheless
used as evidence that cyclamates were carcinogenic. The market collapsed in August 1970
when the FDA banned domestic sales of cyclamates. Abbott, which overnight had suffered the
loss of one of its most profitable operations, protested the ban, but was unable to reverse the
decision. Although the company continued to petition the FDA, subsequent studies confirmed
that metabolization of cyclamates can lead to chromosome breakage and bladder cancer.
Less than a year after cyclamates were banned, Abbott was forced to recall 3.4 million bottles
of intravenous solution. The bottles were sealed with a varnished paper called Gilsonite,
which, it was discovered, harbored bacteria. The contamination was discovered only when
healthcare workers noticed and then investigated the high incidence of infection in patients
who had been administered Abbott's intravenous solutions. The Center for Disease Control
linked the contaminated solutions to at least 434 infections and 49 deaths. With sales down
from $17.9 million to $3 million, Abbott's share price began to fall. Abbott moved quickly to
replace its Gilsonite seals with synthetic rubber, but the company was unable to regain its
leadership of the intravenous market. Litigation resulted in the company eventually pleading
no contest to a charge of conspiracy and paying a $1,000 fine.
division at Abbott resulted in a revenue increase of 139 percent for that division between 1974
and 1979. He correctly predicted that the next most profitable trend in healthcare would be
toward cost-effective analysis and treatment. Schoellhorn was later promoted to president and
chief operating officer of the company. Meantime, in 1977 Abbott entered into a joint venture
with Takeda Chemical Industries, Ltd. of Japan called TAP Pharmaceuticals Inc. for the
codevelopment and comarketing of pharmaceuticals.
Abbott Laboratories registered an annual sales growth rate of 15.5 percent and an earnings
growth rate of 16.5 percent by 1979. This expansion was attributed by financial analysts to the
company's increased productivity, reduced costs, expansion into foreign markets, and greater
involvement in hospital nutritionals and diagnostic testing equipment. The company also
introduced three new drugs in 1979: Depakene, an anticonvulsant; Tranxene, a mild
tranquilizer; and Abbokinase, a treatment for blood clots in the lungs. All three products were
the direct result of the company's increased investment in research and development in the
mid-1970s.Utilizing its knowledge of intravenous solution production, vitamin therapy, and
infant formula, Abbott developed a comprehensive nutritional therapy program to speed the
recovery of hospital patients and thereby reduce medical care costs. In the 1980s, as many as
65 percent of all hospital patients suffered from some form of malnutrition, so Abbott was
highly successful in marketing their program. Another advantage of adult nutritional products
was that they had a place in the growing home care market.
Abbott had similar success marketing its lines of diagnostic equipment. Electronic testing
devices developed by Abbott proved more accurate than manual procedures. In order to
strengthen the technical end of its diagnostic equipment research, Abbott hired two top
executives away from Texas Instruments to head the division.
Robert Schoellhorn, who advanced to chairperson and chief executive officer in 1979,
continued to emphasize investment in pharmaceutical research and development in the 1980s.
Seven new drugs introduced in 1982 accounted for 17 percent of sales in 1985. Foreign
operations also remained extremely important to Abbott, and the company had more than 75
foreign subsidiaries and manufacturing facilities in more than 30 countries. Schoellhorn
continued to support Ledder's original diversification policy. The introduction of Murine eyecare products and Selsun Blue dandruff shampoo served to expand the domestic consumer
product line and promised to provide earning stability in the event of a downturn in any of the
company's other markets.
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Schoellhorn was also credited with promoting Abbott's emphasis on diagnostic equipment,
especially blood analyzers. These devices were increasingly used to detect legal and illegal
substances in the bloodstream. Abbott led the trend, developing the first diagnostic tests for
Acquired Immune Deficiency Syndrome (AIDS), in 1985, and hepatitis. The company's
'Vision' blood analyzer fit on a desktop and performed 90 percent of typical blood tests within
eight minutes. By the end of the 1980s, sales of blood analysis devices represented a billiondollar business, and medical diagnostic products (at $2.3 billion per year) constituted nearly
half of Abbott's annual sales. Meanwhile, in the pharmaceuticals arena, Abbott in 1987
received FDA approval for a new drug called Hytrin for the treatment of hypertension. Hytrin
was approved in 1993 for the treatment of noncancerous enlarged prostate.
Schoellhorn was widely praised as the driving force behind Abbott's phenomenal growth
during the 1980s--sales nearly tripled, profits doubled, and the pharmaceutical company rose
to 90th from 197th on Fortune's list of the world's top 500 companies. The leader's aggressive
management style, however, often led to conflict. Over the course of the 1980s, three
presidents--James L. Vincent (1981); Kirk Raab (1985); and Jack W. Schuler (1989)--quit. In
December 1989, Abbott's board of directors unseated Schoellhorn, who in turn sued the
company for his job. Abbott accused Schoellhorn of misappropriation of company assets and
'fraudulent conduct,' adding that the former CEO exercised stock options worth $9.3 million
within days of his release. Schoellhorn was succeeded by Vice-Chairman Duane L. Burnham.
acquire ALZA Corporation for $7.3 billion in stock. ALZA was a leading producer of
advanced drug-delivery systems and had a solid pipeline of new pharmaceuticals under
development. The Federal Trade Commission (FTC), however, raised antitrust concerns about
the merger, and when the two sides were unable to reach an agreement with the FTC, they
called off the merger in December. Another possible factor in the collapse of the deal was the
decline in Abbott's stock price following the company's agreement in November to pull 125
types of medical-diagnostic test kits off the U.S. market and to pay a $100 million civil
penalty to the U.S. government. Since 1993 the FDA had been issuing warnings to Abbott
regarding quality control deficiencies at its test kit plants, with the market withdrawal and
payment of the fine being the outcome of this process. The FDA also cited poor
manufacturing controls as the reason for its halting the sales of Abbott's clot-dissolving agent
Abbokinase in early 1999.
In the meantime, Abbott managed to complete two smaller acquisitions in 1999. It acquired
Perclose, Inc., a maker of sutures used to close arteries during angioplasty procedures, for
about $600 million in stock. Abbott also paid $217 million in cash to Glaxo Wellcome Inc. for
five anesthesia products. In January 2000 Abbott sold its agricultural products business to
Sumitomo Chemical Co., Ltd. Abbott was now for the first time in decades a pure healthcare
firm. Abbott in April of that year began marketing Biaxin XL, a new once-daily formulation
of its flagship Biaxin antibiotic. The FDA in September 2000 granted expedited approval to
Kaletra, a second-generation AIDS medication developed by Abbott. Kaletra had the potential
to overtake the top AIDS drug, Pfizer Inc.'s Viracept, because it had fewer side effects. It also
appeared that patients did not develop resistance to Kaletra over time, as happened with most
other AIDS drugs, including Viracept. Then in December 2000 Abbott launched another
attempt at a major acquisition when it reached an agreement to acquire the Knoll
Pharmaceutical Co. unit of German chemical giant BASF AG for $6.9 billion in cash. Once
again, Abbott's aim was to bolster its product pipeline, and Knoll had at least one potential
blockbuster in a drug called D2E7, an experimental rheumatoid arthritis treatment. Knoll's
existing products included Meridia, an obesity drug with annual sales of about $400 million,
and Synthroid, a $150 million thyroid drug.
In 2010, Abbott Laboratories acquired Piramal Healthcare Ltd.s branded generic-medicine
unit in India for $3.72 billion, making it the countrys biggest drug maker and tapping into a
market expected to more than double by 2015. Abbott said it will pay $2.12 billion upfront
and $400 million annually for four years from 2011 for the unit, which sells retail-ready
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pharmaceuticals in India, Sri Lanka and Nepal. The Abbott Park, Illinois-based company will
pay cash for the transaction, expected to close in the second half of 2010.
The acquisition is the second-largest takeover in Indias health-care industry and gives Abbott
a 7 percent stake in the $8 billion Indian pharmaceutical market. The move fits into Abbotts
strategy of broadening its business beyond brand-name pharmaceuticals in the U.S. and
Europe, where sales are slowing because of generics competition and pricing pressure from
governments.
In India, the pharmaceutical market is expected to increase as much as 16 percent a year
through 2014, according to IMS Health Inc. The $300 billion U.S. market will grow at a
slower rate of 3 percent to 6 percent over the same period, said IMS. The slower growth in the
U.S. and Europe has Abbott and other drug maker turning toward developing countries to
increase sales. Tokyo-based Daiichi Sankyo Co. bought 64 percent of Ranbaxy Laboratories
Ltd., Indias largest drug maker, for about 488.7 billion yen ($5.45 billion) in 2008, the
biggest takeover in the South Asian nations pharmaceutical industry, and Pfizer Inc. has been
licensing products from Indian generic-drug maker Aurobindo Pharma Ltd.
Recognition
Barron's: Listed No. 29 in 2012 ranking of world's 100 most respected companies
Barron's: Miles White among worlds 30 "Most Respected CEOs" four straight years
The Deal magazine: Most Admired Corporate Dealmaker in health care four straight
years
Working Mother: "100 Best Companies for Working Mothers" 11 straight years
Science and The Scientist magazines: Recognized as a top employer for scientists
for many years
Key Dates:
1888
1900
1915
1929
1936
1952
1964
1967
1970
1971
1977
Company forms joint venture with Takeda Chemical Industries, Ltd. of Japan
called TAP Pharmaceuticals Inc.
1985
1987
1991
1996
1999
Abbott agrees to acquire ALZA Corporation for $7.3 billion but the deal later
collapses; Abbott agrees to pay a $100 million fine relating to quality control
problems at its medical test kit plants; suture maker Perclose, Inc. is acquired.
2000
FDA approves the AIDS drug Kaletra; Abbott agrees to acquire the Knoll
Pharmaceutical Co. unit of BASF AG for $6.9 billion in cash.
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1944:
All shares issued to Boots Pure Drug Co., Ltd. Only 5 shares issued for cash
1963:
1965:
1969:
1976:
1977:
1,48,150 Right Equity shares issued to Indian shareholders (prem. Rs 3.50 per
shares: prop. 2:9)
1979:
1983:
1984:
1986:
4,27,280 new equity shares were offered as Rights to the resident Indian equity
shareholders at a premium of Rs 45 per shares
1987:
The Company received a letter of intent for both the products and the expansion
capacity of Ibuprofen was being implemented
40,50,000 bonus equity shares issued in prop. 1:1
1988:
1989:
A number of new products, namely Brufen Junior Syrup, Chota Strepsils Icy,
Optrex Eye Lotion, Highly Purified Insulins and Nausidome were launched during
the year
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1994:
1995:
1997:
The Company has acquired the product Epilex for a total consideration of Rs 9.90
crores. The product is used in the treatment of epilepsy
The new Goa plant of Knoll Pharmaceuticals, a part of the BASF group, has been
set up. BASF India has also set up two state-of-the-art plants to manufacture
speciality dyes and dispersons in Mangalore and these were commissioned.
1998:
1999:
Beem Healthcare which was engaged in marketing of consumer brands has been
merged with Knoll with effect with July 1998
Knoll Pharma has entered into a three-way pact with the Gujarat-based Torrent
Pharmaceuticals and Danish giant, Novo Nordisk, in the anti-diabetes segment
2000:
The Company has entered into a agreement with Kalpataru Homes for the
assignment of the leasehold
Ranbaxy Laboratories Ltd has entered into an agreement with Knoll Pharmaceuticals Ltd to market the latter's leading brands in select overseas markets
2001:
2002:
Knoll Pharmaceuticals, the maker of popular painkiller Brufen, has changed its
name to Abbott India following global takeover of Knoll's majority stakeholder German firm BASF Pharma - by US drug major Abbott Laboratories
2003:
Mr V D Narkar, Director of Abbott India Ltd, has resigned with effect from June
19, 2003
Mr.Ashok Dayal is appointed as Additional Director of the company
Scheme of amalgamation of Lenbrook Pharmaceuticals (a wholly owned subsidiary of the company) with the company
2008:
Abbott India Ltd has informed that the Board of Directors of the Company at its
meeting held on February 14, 2008, has appointed Mr. Thomas Dee as the
Additional Director of the Company
2010:
Competition Overview
Competition is mainly from the domestic manufacturers and imports from
China because of the low manufacturing cost. With the new patent regulations the industry
expects to see a major structural shift with the entry of foreign pharmaceutical manufacturers.
There are five government-owned companies the Indian public sector. These companies are
the Indian Drugs and Pharmaceuticals, Hindustan Antibiotics Limited, Bengal Chemicals and
Pharmaceuticals Limited, Bengal Immunity Limited and Smith Stanistreet Pharmaceuticals
Limited. Some of the major Indian private companies are Alembic Chemicals, Aurobindo
Pharma, Ambalal Sharabhai Limited, Cadila Healthcare, Cipla, Dr. Reddys, IPCA
Laboratories, Jagsonpal Pharma, J.B. Chemicals, Kopran, Lupin Labs, Lyka Labs, Nicholas
Piramal, Ranbaxy Labs, Matrix Laboratories, Orchid Chemical and Pharmaceuticals, Sun
Pharmaceuticals, Ranbaxy Laboratories, Torrent Pharma, TTK Healthcare, Unichem Labs,
and Wockhardt. The foreign companies in India include Abott India, Astra Zeneca India,
Aventis Pharma India, Burrough-Wellcome, Glaxo SmithKline, Merck India, Novartis, Pfizer
Limited, and Wyeth Ledele India.
Company Name
1348.51
Ranbaxy
1327.56
1178
Lupin Ltd
929.84
Aurobindo Pharma
865.19
Dabur
700.3
Sun Pharmaceutical
673.99
Cadila Healthcare
629.45
561.03
10
475.8
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CHAPTER 2
Research Methodology
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Research Methodology
A questionnaire was prepared to gauge the awareness of new molecule in customer.
Survey has been done out of the company covering a wide cross-section of the
industry.
The question was presented in one to one interview with each of the respondents.
Responses of the concerned persons had been thoroughly analyzed.
Conclusions had been arrived at using the response of the concerned persons and not
on questionnaire alone.
Generally speaking, doctors are most reserve persons on the planet and they are not flattered
by attention and this sometimes overcomes any inhibitions so that matters quite secret are
paraded before the observer with seeming abandon. At other times, particularly where an issue
has been the subject of recent press attention, the shutters go up and there is no way in. All
you can do in such circumstances is to give up and try something else likely to be more
productive - you haven't the time to spend on lengthy negotiation. Crucial to the business of
initially gaining access is the whole matter of assurances of confidentiality, anonymity, etc,
which I consider below. Your stance, once granted access, depends on how much of an active
participant you want to be in the arena you are observing - the more obviously committed you
are to one particular stance or ideology the more others will take this into account when
revealing their thoughts or their actions to you.
In this context the questionnaire was not a fully fledged one and was made with an intention
of getting the main information as doctors dont have that much time to spare and also a long
questionnaire may irritate them. So the questionnaire used in my research was really crisp and
was aimed at getting the required information in the least time, also the questionnaire was
used for primary purpose only.
33 | P a g e
Research Design
Research design specifies the methods and procedures for conducting a particular study. A
research design is the arrangement of conditions for collection and analysis of the data in a
manner that aims to combine relevance to their search purpose with economy in procedure.
Research design is broadly classified into three types as:
Exploratory Research Design
Descriptive Research Design
Causal Research Design
Descriptive Research Design
Descriptive research studies are those studies which are concerned with described the
characteristics of particular individual. In descriptive as well as in diagnostic studies, the
researcher must be able to define clearly, what he wants to measure and must find adequate
methods for measuring it along with a clear cut definition of population he want to study.
Since the aim is to obtain complete and accurate information in the said studies, the procedure
to be used must be carefully planned. The research design must make enough provision for
protection against bias and must maximize reliability, with due concern for the economical
completion of the research study.
SAMPLE DESIGN
A Sample Design is a definite plan for obtaining a sample from a given population. It refers to
the technique to the procedure adopted in selecting items for the sampling designs are as
below:
SAMPLE SIZE
The sample size has been 40 doctors. Conclusions had been arrived at using the response of
the questionnaire.
SAMPLING METHOD
In this marketing research project, I am using Random sampling method.
SAMPLE TYPE
Area Sampling, and the area of sampling is Mumbai & Pune.
34 | P a g e
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36 | P a g e
CHAPTER 3
Conceptual Discussion
37 | P a g e
Current Issue/News
March 21, 2012
Company Remains on Track for Separation into Two Publicly Traded Global Health
Care Companies by End of 2012
Abbott Park, Illinois (NYSE: ABT) Abbott today announced that AbbVie [pronounced
Abb-vee] will be the name of the new, independent research-based pharmaceutical company it
expects to launch by the end of 2012.
The naming of the new company is the latest milestone in the process that began in October
2011, when Abbott announced it would separate into two publicly traded companies, one in
diversified medical products and the other in research-based pharmaceuticals. AbbVie, the
research-based pharmaceutical company, will include Abbotts current portfolio of leading
proprietary pharmaceuticals and biologics. The diversified medical products company, which
will retain the Abbott name, will consist of Abbotts existing diversified medical products
portfolio, including its branded generic pharmaceutical, devices, diagnostics and nutritional
businesses. Both companies will be global leaders in their respective industries.
Miles D. White will remain chairman and CEO of Abbott. Richard A. Gonzalez, currently
executive vice president, Global Pharmaceuticals, will become chairman and CEO of AbbVie.
The name is derived from a combination of Abbott and "vie," which references the Latin root
"vi" meaning life.
"The beginning of the name connects the new company to Abbott and its heritage of
pioneering science," said Mr. Gonzalez. "The 'vie' calls attention to the vital work the
company will continue to advance to improve the lives of people around the world."
39 | P a g e
living with diabetes.2 Among the products being developed for the Indian market are meal
complements for diabetics and pre-diabetics. In addition, the center will address local taste
and texture preferences with new flavors and formulations.
"India is a priority market for investment, growth and innovation," said Robert H. Miller,
Ph.D., divisional vice president, Global R&D and Scientific Affairs for Abbott Nutrition.
"Our strategic collaboration with Syngene will accelerate the design, development and
delivery of science-based, affordable nutrition products in India, for India."
"Health care in India has reached a tipping point as patients seek quality care and products at
affordable prices," said Rehan Khan, managing director, Abbott Nutrition India. "We have
consistently invested in India, and this world-class R&D center will allow us to leverage local
expertise and insights to develop the products we need to successfully expand our portfolio
here."
The nutrition market in India is relatively new and growing steadily. In addition to the
undernutrition and diabetes issues facing India, a rapidly expanding middle class and aging
population are driving increased demand in the country for high-quality, affordable nutrition
products.
"With malnutrition and common chronic diseases at their highest in this region, Abbott and
Syngene have a common vision and commitment to support the development of a healthier
India," said Kiran Mazumdar-Shaw, founder, chairman and managing director, Biocon Group.
"The combined market insights and nutrition science expertise of our two organizations will
enable us to address these immediate needs by developing critically important, innovative yet
affordable nutrition products for the Indian population."
Commenting on the collaboration, Peter Bains, director, Syngene & Clinigene, said, "We are
extremely delighted to partner with Abbott for this synergistic collaboration for its nutrition
business. Our objective will be to develop new products for Abbott's nutrition portfolio. This
symbolizes Syngene's growing capability to offer science-based research and development
solutions across a wide range of life science platforms."
41 | P a g e
About Abbott
Abbott (NYSE: ABT) is a global, broad-based health care company devoted to the discovery,
development, manufacture and marketing of pharmaceuticals and medical products, including
nutritionals, devices and diagnostics. The company employs approximately 91,000 people and
markets its products in more than 130 countries. Abbott currently employs more than 12,000
people throughout India.
About Abbott Nutrition
For more than 85 years, Abbott Nutrition has been developing and marketing science-based
pediatric and adult nutritional products to support the growth, health and well-being of people
of all ages. Abbott offers a variety of nutritional products in India including PediaSure
(complete, balanced nutrition for children), Similac (infant milk formula for infants and
children), Mama's Best (nutritional supplement for pregnant and breastfeeding mothers),
Ensure (adult nutritionals), Glucerna (nutrition for people with diabetes) and Prosure
(nutrition for people with cancer).
About Biocon Limited
Biocon Limited (BSE code: 532523, NSE Id: BIOCON, ISIN Id: INE376G01013) is India's
premier biopharma enterprise focused on innovation to deliver affordable health care solutions
to patients, partners and health care systems across the globe. Established in 1978 by Ms.
Kiran Mazumdar-Shaw, Biocon is committed to reduce therapy costs of chronic diseases like
diabetes, cancer and autoimmune diseases to provide access to affordable treatment to patients
globally. Biocon's key innovations include the world's first Pichia-based recombinant human
Insulin, INSUGEN, insulin analog Glargine, BASALOG and India's first indigenously
produced monoclonal antibody, BioMAb-EGFR, for head & neck cancer. INSUPen is a
next-generation affordable insulin delivery device introduced in India. With a risk-balanced
business model comprising small molecules, novel molecules, biosimilars, branded
formulations and research services, Biocon has evolved into an emerging global enterprise
serving its partners and customers in over 70 countries.
More information is available at www.biocon.com
42 | P a g e
43 | P a g e
CHAPTER 4
Data Analysis
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45 | P a g e
I. Editing
The first task in data processing is the editing. Editing is the process of examining
errors and omissions in the collected data and making necessary corrections in the
same.
II. Coding
Coding is necessary to carry out the subsequent operations of tabulating and analyzing
data. If coding is not done, it will not be possible to reduce a large number of
heterogeneous data into meaningful categories with the result that the analysis of data
would be weak and ineffective, and without proper focus.
III. Tabulation
Tabulation comprises sorting of the data into different categories and counting the
number of cases that belong to each category. This is also called universal tabulation.
The analysis based on just one variable is obviously meager. Where two or more
variables are involved in tabulation, it is called vicariate or multivariate tabulation.
IV. Analysis
After the all three above steps, the most important step is analysis of the data.
46 | P a g e
DETAIL ANALYSIS
OBJECTIVE 1: NMB Molecule Practiced by Doctors
In the process of market survey, the first thing to determine was to find out the Neuromuscular
Blocker (NMB) preferred by the doctors in their clinical practice. Out of those visited, the
information has been collected and it has been noticed that though most of the Doctors
preferred one or more available NMB molecule.
Hence, in order to find out the actual figure for the preference of the available NMB, the
criteria has been set to find out the actual preference of the NMB by doctors.
This is done by maintaining the criteria for NMB preference by doctors, if the percentage of
consumption of the particular molecule is 50 % or more than only it is counted in the
following chart:
16%
Atracurium
19%
65%
Vecuronium
Rocuronium
47 | P a g e
INFERENCE
65% of doctors Preferred Atracurim than any other available molecule and their
percentage of consumption ranged above 50% to 90%, some of them were using 100%
only Atracurium
The 2nd and 3rd preference by doctors were consecutively Vecuronium and
Rocuronium, with 19% and 16% respectively
Other molecules, like Pancuronium & Succinylcholine too stand in the preferred list of
molecules but their percentage of consumption is too less to be considered in the
above chart.
21%
Atracurium
11%
Vecuronium
68%
Rocuronium
48 | P a g e
33%
58%
Vecuronium
Rocuronium
INFERENCE
From the above chart, it is quite obvious that Atracurium is the most preferred
molecule in both Pune & Mumbai Region.
But, another fact noticed here is that Rocuronium is the 2nd best preferred and
consumed in Mumbai, while it is Vecuronium in the case of Pune.
49 | P a g e
90%
77%
80%
74%
70%
60%
55%
50%
40%
30%
22%
23%
20%
16%
16%
10%
7%
10%
0%
Atracurium
Vecuronium
Rocuronium
< 30 % of Consumption
30 - 60 % of Consumption
> 60 % of Consumption
INFERENCE
The above Chart gives the clear view of the actual percentage of consumption of each
molecule.
As seen above, Atracurium is the most preferred as well as most consumed molecule
compared to Vecuronium & Rocuronium,
55% of doctors have higher degree of consumption of Atracurium, i.e. - more than
60%. While in the case of both Vecuronium and Rocuronium, only less than 20% of
doctors consumption value ranges in the same category.
Again, from the chart it can be easily determined that Vecuronium has edge over the
Rocuronium in terms of consumption which lies between 30-60%.
Pancuronium is no more practiced in the GA procedures. Only one or two cases were
found where Pancuronium is still being practiced, but in very few cases.
Apart from this, Succinylcholine is used in the most of GA procedures, but its use is
mostly restricted to the intubation cases or difficult airway cases.
50 | P a g e
35%
30%
13%
13%
9%
9%
17%
48%
26%
Safety
52%
39%
5%
4%
Recovery Time
9%
13%
52%
13%
13%
Potency
4%
9%
13%
22%
52%
Onset of Action
Duration of Action
With respect to above table it can be concluded that, in Mumbai doctors prefer the following
characteristics in an ideal NMB.
(The list given below is in ascending order)
1. Safety
2. Onset Of Action
3. Recovery Time
4. Duration of Action
5. Potency
51 | P a g e
Onset of Action
14%
36%
7%
29%
14%
Duration of Action
7%
29%
43%
14%
7%
Safety
79%
14%
7%
Recovery Time
29%
50%
21%
Potency
22%
14%
7%
57%
With respect to above table it can be concluded that, in Pune doctors prefer the following
characteristics in an ideal NMB.
(The list given below is in ascending order)
1. Safety
2. Onset Of Action
3. Duration of Action
4. Recovery Time
5. Potency
INFERENCE
From the data collected, it can be easily figured out that Safety is the most important
characteristics that doctors seek in any molecule, while Potency is the least important
characteristics in the list.
Considering the above facts now the data is further compiled and analyzed to get a real
picture of the preference.
52 | P a g e
Onset of Action
27%
32%
11%
19%
11%
Duration of Action
3%
16%
27%
35%
19%
Safety
62%
30%
5%
3%
Recovery
5%
8%
44%
27%
16%
Potency
3%
13%
14%
16%
54%
With respect to above table it can be concluded that, doctors prefer the following characteristics in an ideal NMB (the list given below is in ascending order):
1. Safety
2. Onset Of Action
3. Recovery Time
4. Duration of Action
5. Potency
On compilation of entire sample size, it is now clear that Safety is the most important element
in the molecule which doctors values most, followed by Onset of action, Recovery Time,
Duration of Action and last Potency.
Out of the whole sample size, 62% of the sample space considers Safety to be most ideal
characteristics in NMB.
53 | P a g e
Onset Of Action
Atracurium
6%
Rocuronium
44%
Pancuronium
3%
Succinylcholine
47%
54 | P a g e
Duration Of Action
Succinylcholine
3%
Pancuronium
22%
Rocuronium
17%
Vecuronium
25%
Atracurium
33%
Recovery Time
Rocuronium
22%
Succinylcholine
6%
Cisatracurium
5%
Atracurium
67%
55 | P a g e
Safety
Rocuronium
19%
Cisatracurium
11%
Vecuronium
28%
Atracurium
42%
Potency
Pancuronium
8%
Vecuronium
33%
Atracurium
14%
Rocuronium
42%
Succinylecholine
3%
56 | P a g e
70%
60%
% of Doctors
50%
40%
30%
20%
10%
0%
Atracurium
Onset of Action
6%
Rocuroniu
m
44%
Vecuroniu
m
0%
Succinylch
oline
47%
Pancuroni
um
3%
Cisatracuri
um
0%
Duration Of Action
33%
17%
25%
3%
22%
0%
Recovery Time
67%
22%
0%
6%
0%
5%
Safety
42%
19%
28%
0%
0%
11%
Potency
14%
42%
33%
3%
8%
0%
Chart 10: Overall % of doctors supporting NMB with its best attribute
INFERENCE
From the above chart the positioning of the molecules can be easily derived.
While considering the Safety aspect of NMB, 42% doctors consider Atracurium as the
safest NMB followed by Vecuronium & Rocuronium.
47% of doctors are with Succinylcholine & 44% of doctors are with Rocuronium, in
terms of onset of action.
In terms of recovery time, 67% of doctors consider Atracurium the best neuromuscular
agent.
With the 42% of doctors supporting Rocuronium, it is considered the most potent
NMB agent.
Most interesting fact came in the study is that, before the launch of Cisatracurium- it
has positioned itself as the safe molecule and also holds a position with good recovery
time.
57 | P a g e
Succylincholine
5%
5%
Atracurium
87%
Atracurium is the most commonly used molecule in less than < 30 minutes surgery
procedure.
Vecuronium is the least preferred molecule with the above parameters.
58 | P a g e
Rocuronium
3%
Vecuronium
26%
Atracurium
58%
Vecuronium
26%
59 | P a g e
INFERENCE
From the above chart, it is evident that 87% doctors prefer Atracurium in <30 minute
surgery while only 58% doctors prefer Atracurium in 30-60 min. surgery procedure.
But, the percentage is quiet low in case of >60 minute surgery. Only 32% doctors
prefer Atracurium in long surgery procedure.
Vecuronium is the second most preferred molecule in the 30-60 minutes surgery
procedure.
Though Pancuronium is very less in clinical practice these days. But still 13% of
doctors prefer it in 30-60 minutes procedures.
From the above facts, it is quite clear that choice of NMB in GA is also dependent of
the surgery duration.
Pancuronium
Longer acting
Rocuronium
Duration
Safe
Better relaxant
No repetition
Longer duration of action
60 | P a g e
Atracurium
Vecuronium
No cardiac effect
Longer duration of action
Intermediate acting
Cardiostable & Potent NMB agent
Top ups needed after some reasonable period
Potency & Safety
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21%
Yes
No
79%
62 | P a g e
100%
90%
24%
16%
16%
80%
63%
70%
60%
92%
50%
84%
40%
84%
76%
30%
37%
20%
10%
8%
0%
Atracurium
Rocuronium
Vecuronium
Yes
#Cisatracurium Succinylcholine
NO
Chart 15: Distribution of NMB Agents with their % of Need of Reversal Agent
Note: - In terms of Cisatracurium, most of the doctors resisted in providing opinions about it
since they werent using it. Hence, total sample size is only 16 in the case of Cisatracurium.
Out of which, 63% of doctors believed it dont any reversal agent.
Reasons for the Need of Reversal Agent as mentioned by Doctors
The patient should be reversed even though it is a self reversal agent, to rule out
residual blockade if any.
Hoffmans elimination
Major findings from the above analysis and chart can be concluded as:
79% of doctors have a belief that a patient must be reversed, even though if it is a self
reversal agent.
Though, it is not true in the case of Succinylcholine, 92% dont use any reversal agent
with it.
Rocuronium & Vecuronium stands at similar situation having 84% doctors using
reversal while used in GA.
Most important concept in the analysis came out as, Cisatracurium is considered as
self reversal agent as likes of Succinylcholine.
64 | P a g e
24%
Different NMB
76%
Same NMB Agent
0%
10%
20%
30%
40%
50%
60%
70%
80%
Since, percentage of doctors using the different NMB molecule in intubation and
maintenance is very low but most of doctors still mix the molecule as per the patient norms.
Mostly, it depends on the type of surgery and the criticality of the case. Availability of
molecule also influences the decision of using the same NMB agent in intubation as well as in
maintenance.
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Atracurium/Vecuronium/Rocuronium/Pancuronium
Rocuronium
Atracurium
Atracurim
Vecuronium
Vecuronium
Atracurium
From the above facts & feedbacks collected in research process, it can be said mostly
Succinylcholine is used in intubation and continued by any of the muscle relaxant available or
the muscle relaxant of their choice. But, as the above chart shows 76% doctors dont mix the
molecules in surgery procedures. If Atracurium/Rocuronium is used in intubation than it is
followed by same molecule in maintenance. Only in few cases, Rocuronium is followed by
Atracurium & Atracurium is followed by Vecuronium
66 | P a g e
B
C
D
18%
3%
13%
F
3%
67 | P a g e
11%
8%
A
41%
16%
C
D
24%
68 | P a g e
INFERENCE
From the chart above, it can be derived that:- 41% of doctors out of total sample size, thinks Cisatracurium can be used in all GA
procedures.
- 24% of doctors feel it will be useful only in GA procedures below 30 minutes of
surgery duration.
- Rest all has the mix opinion about Cisatracurium.
- One of the major findings, from the above analysis is that majority of doctors feel it
can be used in all the GA procedures.
Though, Cisatracurium is yet to be launched in India. Hence the initial opinion about the
molecule has positive response from doctors. Some of doctors consider that Cisatracurium is
more useful in Kidney disease patients. One of the other positioning characteristics of
Cisatracurium came in research process is that, few doctors has belief that Cisatracurium may
not require reversal agent as complete recovery is possible out of it.
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CHAPTER 5
Findings, Conclusion
And Suggestions
70 | P a g e
INTERPRETAION
Abbott Labs strength is in its differentiation. Its strength in differentiation comes from the
immense diversity of products the company offers that are considered innovative and unique
compared to products made by competitors. Abbott Labs produces pharmaceutical, medical,
and nutritional products. They are the leading innovators in anesthetics, and diabetes care.
Abbotts financial performance is consistent with its mission, objectives, and organizational
environment. The companys vision is Always at the forefront, always first choice, and the
company embraces the idea of focusing on a culture of continuous improvement and a
dedication towards organizational excellence. This includes the improvement of employees,
products, and the company as a whole. Abbotts greatest differentiator is in the diverse mix of
their business portfolio. Abbotts broad line of products and the success of their employees is
what contribute to such high numbers, as well as the companys ability to produce what
people need throughout the world, medically, pharmaceutically, and nutritionally.
The industry is changing fast. To survive and to prosper involves managing drug pipelines
as drugs come off patents they no longer bring in enough revenues and must be replaced
quickly by other drugs with durable patents. This means that the companies have to think
ahead, something that sounds easy but involves great risks. Huge sums must be invested in
uncertain in-house research and development and/or must go toward mergers and acquisitions
with other promising companies. Strategic alliances can be used to augment opportunities as
well. As companies develop their new pipelines, they must be mindful of changes caused by
regulations and deregulations in countries all over the globe. The global competitive
environment creates challenges and opportunities for the companies with equal importance
for the communities in which they reside.
This research offers no new insights into what it takes to build a viable new product launch
but it surely underlines two facts that it is worth doing in Indian market and that it will
involve retaining and attracting more market share with financial boost that need to take
sizeable financial risks.
71 | P a g e
From the research, it has been figured out that Safety is the most important
characteristics that individual seek in a NMB agent.
Atracurium has been in the top of the list in their clinical practice in any GA
procedures, followed by Rocuronium and Vecuronium. This creates a good market for
Cisatracurium, since most of the doctors consider it as one of the safest molecule in
the NMB category.
Apart from this, use of reversal agent in GA procedure has been very often or
common. Though, the main reason cited for the need to use reversal has been that,
79% of doctors believe the patient must be reversed.
But, it is not true for all the molecules. In terms of Succinylcholine, 92% doctors
believe it doesnt need any reversal, as it is considered as self- reversal agent. 63% of
doctors have similar belief about Cisatracurium, which gives it competitive advantage
over available NMB agents.
But more than 60 minutes surgery is controlled by nearly equal market share of
Vecuronium, Rocuronium & Atracurium. Where, Rocuronium has edge over the other
two.
From the above analysis it is evident that Atracurium is the most preferred molecule
by doctors and also holds larger market share than other competitors.
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CONCLUSION
The pharmaceutical industry currently represents a highly competitive environment.
Pharmaceutical companies have to operate in a highly regulated environment; the degree of
regulation to a significant extent depends on the country and type of the product. One of the
most important aspects of government regulation for pharmaceutical companies is price
regulation, and different countries have different policies on this issue. As the result of price
control, prices of the same products can significantly differ in different countries.
Abbott Laboratories has been enjoying the long run of its monotonous market in terms of its
product Sevorane. With the new product launch, Cisatracurium it wouldnt be wrong to say
that company will enjoy the similar situation, if price being the competitive factor.
With the Atracurium occupying the maximum market shares in NMB category, it would be
easy to be replaced by Cisatracurium. Since, it is one of the 10 isomers of original molecule
atracurium besylate. Prior to its launch and clinical use Cisatracurium has been well
positioned as self reversal agent. Hence, it has good positioning in terms of need of reversal
agent. Cisatracurium being one of the safest molecule in the NMB category, it can pick up in
the market quiet well. As in the research it has been found that safety is the most important
characteristics that doctor seek in an ideal NMB. Apart from this, majority of doctors has a
belief that it would be essential for all GA procedures.
Hence, it can be considered that the market condition and initial opinion about the product is
ideal for the launch of Cisatracurium.
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SUGGETIONS
The main challenges for drug companies come from four areas. First, they must deal with
competition from within and without. Second, they must manage within a world of price
controls that dictate a wide range of prices from place to place. Third, companies must be
constantly on guard for patent violations and seek legal protection in new and growing global
markets. Finally, they must manage their product pipelines so that patent expirations do not
leave them without protection for their investment.
Lastly, in terms of Cisatracurium the market development is essential which would help the
company in creating increased market share. For this purpose Abbott India Ltd. should focus
on following:
There is a need of self reversal agent in the NMB category, since the Succinylcholine
is only muscle relaxant available hence Cisatracurium should be positioned as self
reversal agent. Most of the individual already believe that it doesnt need any reversal.
Safety and Onset of action are two most vital characteristics for an ideal NMB
which doctors prefer and Cisatracurium is considered to possess both characteristics.
Thus, it should be counted in the marketing strategy of the product.
Cisatracurium is considered to perform better in Kidney & Renal patients. Thus, this
market should be targeted prior to expansion of any other area.
Abbott Labs should launch it India with price being competitive. It will be the best
molecule available in market so if priced competitively it will be picked up like
anything.
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CHAPTER 6
Appendix & Bibliography
75 | P a g e
Percentage of Consumption
Vecuronium
Rocuronium
Succinylcholine
2. What are the characteristics you expect to be in an ideal Neuromuscular Blocker (NMB)?
Put the numbering as per your preference.
Parameters
Preference
Onset of action
Duration of action
Safety
Recovery time
Potency
3. Among the given parameters, which parameter you consider, best defines the below mentioned NMB? (Kindly mark only one molecule with [ ], against each parameter)
Neuromuscular
Blocker Agents
Onset of
Action
Duration of
Action
Recovery
Time
Safety
Potency
Atracurium
Vecuronium
Rocuronium
Succinylcholine
Cisatracurium
Pancuronium
76 | P a g e
4. Kindly mention the dosage protocol you follow for each of the following NMB agents.
Intubation
(mg/kg)
NMB
Maintenance
(mg/kg)
1st maintenance
(Time in min)
2nd maintenance
(Time in min)
Atracurium
Vecuronium
Rocuronium
Succinylcholine
Cisatracurium
Pancuronium
5. Under the following parameters, what is your preference of the NMB molecule? Mention
the quantity of the molecule used along with the reason for the choice.
Surgery
Duration
NMB Agent
Preference
<30
minutes
30-60
minutes
>60
minutes
6. Do you need to use the Reversal agent with the following NMB molecules? If yes, What
is the percentage of surgery procedure in which you have to use reversal agent?
Also give the remarks for its need of use.
Reversal Agent? What % of Procedures?
NMB Agents
Remarks if any?
Yes
No
Atracurium
Vecuronium
Rocuronium
Succinylcholine
Cisatracurium
Pancuronium
7. Do you use the same agent for intubation and maintenance of neuro muscular blockade? If
No, what are the different combinations of NMBs that you use clinically?
Intubation NMB
Maintenance NMB
% of procedures?
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8. According to you, which of the following is the most vital characteristic of the Cisatracurium?
a. More potent than available NMB agents
b. Less risk associated with the molecule
c. Very Less histamine release than Atracurium
d. Among other intermediate acting NMB, it has slower onset of time
9. Considering the above advantages, which of the following will be the ideal condition for
the use of Cisatracurium?
a. All the GA procedures with duration below 30 min
b. All the GA procedures with duration between 30 60 min
c. All the GA procedures with duration above 60 min
Date: -
Signature
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Abbreviations
NMB: Neuro Muscular Blocker
GA: General Anaesthesia
R & D: Research and Development
ABT[NYSE]: ABBOTT[New York Stock Exchange]
E.E.S.: Erythromycin Ethylsuccinate
FTC: Federal Trade Commission
FDA: Food and Drug Administration
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Bibliography
Reference Books
Marketing Management, Philip Kotler 14th Edition
Research Methodology, C. R. Kothari Second Edition
Strategic Marketing Management, Richard M. S. Wilson, 3rd Edition
Medical Journals
Clinical Literatures
Website References
www.generalanaesthesia.info
www.drugs.com
www.wiki-meds.com
www.druglib.com
en.wikipedia.org
www.abbott.co.in
www.abbott.com
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