Penicillin G

MU= million units or mega units = 1,000,000 unit

Spectrum: Actinomycessp, Corynebacterium diphtheria, Clostridium perfringens, Enterococcus faecalis,
Leptospira spp., Propionibacterium acnes, Pasteurella multocida, Peptostreptococci, Strep. Anginosisgp, Strep.
Gp A,B,C,D,F,G, Strep. Pneumoniae, Treponema pallidum.
Inactivated by penicillinase (staph. aureus)
Types Benzylpenicillin Benzathine penicillin Procaine Penicillin G
Common Aq. crystalline penicillin G, C-
Bicillin LA Procaine Benzylpenicillin
name Pen
0.6 mcg sodium penicillin G,
1 unit of
0.625 mcg potassium 0.75 mcg benzathine penicillin G 1 mcg procaine penicillin G
activity
penicillin G
3 MU (3g)
Strength
1 MU (0.6g) , 5MU (3g) 2.4MU (1.8g) Fortified 4 MU (+ 0.6g
(s)
Benzylpenicillin)
Duration: 1 to 4 weeks (dose
t =31-50 mins. Duration: 15 to 24 hours
Pharmacoki dependent)
netic Penetrates into the CSF more easily when the meninges are acutely inflamed. CSF/blood penetration
5-10%, usually effective.
Administrat IV over 15-30mins, dilute in
IM IM
ion 100ml NS
12-24 MU/day in divided
Usual dose 1.2 -2.4 MU as a single dose 300,000- 900,000 U q24H
doses q4-6H
Specific Neurosyphilis Syphilis: primary, secondary, Syphilis: Primary, secondary,
indication 3 to 4 MU q4H OR early latent OR latent (with negative
& Dose 18 to 24 MU/day as a 2.4 MU as a single dose spinal fluid)
continuous IVI, for 10-14 days Syphilis: Late latent, latent 600,000 U q24H for 10 days
(NAG 14 days) of unknown duration, tertiary Syphilis:Tertiary, or late
Leptospirosis 2.4 MU weekly for 3 doses latent (when spinal fluid not
2 MU q6H for 7 days Syphilis in pregnancy tested or positive)
Streptococci meningitis 1st& 2nd trimester :single dose ;
600,000 U q24H for 14 days
4 MU q4-6H for 10-14 days 3rd trimester :2 doses,1wk
Neurosyphilis
Skin infection, Group A apart
Strep Streptococcal pharyngitis 2.4 MU daily (+probenecid
2-4 MU q4-6H (if Necrotizing Acute: 1.2 MU as a single dose. 500mg QID) for 10-14 days
Fasciitis, + Clindamycin)
GBS prophylaxis
 5 MU STAT, then 2.5-3 MU
q4H until delivery

Reference: *refer to NAG for indications other than

mentioned above
1. National Antibitics Guideline 2014. 2nd ed. Ministry of Health.
2. DRUGDEX System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Available at:
http://www.micromedexsolutions.com/ (cited: 12/28/2016)
3. The Sanford Guide to Antimicrobial Therapy.[Mobile application software],Version 1.0.34. (2016). [Cited 2017 January 03].

Prepared by KoayKS. 03/01/2017. Drug Information, Pharmacy Hospital Marudi