Scribd
Upload
611 views1 page

Dengue Hemorrhagic Fever Pathophysiology

The document discusses the pathophysiology of dengue fever. It outlines the predisposing factors like age, heredity, and sex that make one susceptible. The precipitating factors are the bite of an Aedes Aegypti mosquito carrying the dengue virus. The virus then enters the bloodstream and infects cells, replicating in sufficient amounts. This initiates an immune response and the activation of memory T-cells upon re-exposure, stimulating the release of cytokines which can damage cells and tissues. This leads to symptoms like fever, headache, and dizziness. The virus ultimately targets the liver and spleen, causing apoptosis of cells and resulting in thrombocytopenia and hemorrhagic fever.

Uploaded by

karl
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
611 views1 page

Dengue Hemorrhagic Fever Pathophysiology

The document discusses the pathophysiology of dengue fever. It outlines the predisposing factors like age, heredity, and sex that make one susceptible. The precipitating factors are the bite of an Aedes Aegypti mosquito carrying the dengue virus. The virus then enters the bloodstream and infects cells, replicating in sufficient amounts. This initiates an immune response and the activation of memory T-cells upon re-exposure, stimulating the release of cytokines which can damage cells and tissues. This leads to symptoms like fever, headache, and dizziness. The virus ultimately targets the liver and spleen, causing apoptosis of cells and resulting in thrombocytopenia and hemorrhagic fever.

Uploaded by

karl
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOC, PDF, TXT or read online on Scribd
  • Pathophysiology of Dengue Hemorrhagic Fever: The section provides a detailed flowchart explaining the factors and biological processes involved in Dengue Hemorrhagic Fever.

X.

Pathophysiology

Predisposing Factors:
Precipitating Factors: Bite of a virus carrying
Age, Heredity, Sex, Age
Aedes Aegypti mosquito
Mosquito
Environment (open
spaces with water) Mosquito injects fluid into patients
skin

Platelet will provide a shield


Virus enters into the hosts blood
for the virus from exposure
stream
and binding to neutralize
pre-existing antibody
Infects cells and replicate in sufficient
amount

Macrophages or monocytes Initiates an immune response


engulfed the virus having the
platelet (phagocytosis)
Activation of memory T-cell response Stimulates release
during re-exposure of cytokines

Vasculopathy Virus- anti body complex


(Binding of ab-virus) High fever, body
(Plasma
weakness,
leakage)
headache and
dizziness
AB- enhance uptake
Cytokines destroy cell
Coagulopathy membrane and cell wall (viral
(PT/APTT) antigens found in monocytes)
Cytolysis

Cellular direct destruction and Complement system activation


Virus ultimately targets liver and infection of red bone marrow
spleen parenchymal cells where precursor cells as well as
infection produces apoptosis/cell immunological shortened platelet
death survival causing platelet lyses
Vascular endothelial activation

Hepatosplenomegaly Thrombocytopenia

Dengue Hemorrhagic
Fever

Legend:

*words formatted as bold, were manifested by the client

You might also like