Protocol for the administration of Teicoplanin

(Adults)
Teicoplanin IV Dosing Guidance

Indication Dosage Expected therapeutic

through levels
Bone and Joint
infections
S. aureus sepsis
(MRSA, MSSA) 10mg/kg to nearest 100mg
Severe sepsis/septic (maximum 800mg per dose) 20 to 40 mg/L
shock for 3 loading doses 12
Intravenous drug hours apart then every 24
abusers hours*
Burns

70Kg weight
600mg for 3 loading doses
12 hours apart then every
24 hours
No need to monitor levels
Other infections <70 Kg weight routinely;
400 mg for 3 loading doses unless acute renal failure
12 hours apart then every aim for:
24 hours 10 to 40 mg/L

*Teicoplanin blood levels should be measured to ensure therapeutic

concentrations are achieved. Please send trough level before 4th dose; if sub
therapeutic level discuss with Microbiologist.

Most patients do not require further drug level monitoring unless prolonged
antibiotic therapy is scheduled.

Renal Failure dosage

In severe renal failure full loading dose is required, subsequent maintenance dose
will vary according to CrCl and use of renal replacement therapy, liaise with
Pharmacist and or Microbiologist.

Intravascular Infections
Patients with Intravascular infections/endocarditis and patients with significant
renal failure require careful monitoring; in these cases frequent dose monitoring is
indicated and should be discussed with Microbiology.

Produced by the Antibiotic Management Team 2010, ratified March 2010

Dr JA Cepeda, Consultant Microbiologists & T Keyser, Antibiotic Pharmacist Review March 2012