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  • SIRS, Sepsis, Severe Sepsis and Septic Shock Defined

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    jamesomoore
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    This document outlines the differences between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock. SIRS involves two or more symptoms but no confirmed infection, while sepsis involves SIRS plus a confirmed infection. Severe sepsis occurs when sepsis leads to organ dysfunction or hypoperfusion. Septic shock is defined as sepsis with refractory hypotension despite fluid resuscitation. Early goal directed therapy aims to achieve specific clinical targets within 6 hours to treat severe sepsis and septic shock.

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    Sepsis guidelines 2017

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    Sepsis

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    This document outlines the differences between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock. SIRS involves two or more symptoms but no confirmed infection, while sepsis involves SIRS plus a confirmed infection. Severe sepsis occurs when sepsis leads to organ dysfunction or hypoperfusion. Septic shock is defined as sepsis with refractory hypotension despite fluid resuscitation. Early goal directed therapy aims to achieve specific clinical targets within 6 hours to treat severe sepsis and septic shock.

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    11 views2 pages

    SIRS, Sepsis, Severe Sepsis and Septic Shock Defined

    Uploaded by

    jamesomoore
    This document outlines the differences between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock. SIRS involves two or more symptoms but no confirmed infection, while sepsis involves SIRS plus a confirmed infection. Severe sepsis occurs when sepsis leads to organ dysfunction or hypoperfusion. Septic shock is defined as sepsis with refractory hypotension despite fluid resuscitation. Early goal directed therapy aims to achieve specific clinical targets within 6 hours to treat severe sepsis and septic shock.

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    © All Rights Reserved
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    of 2

    SIRS / SEPSIS / SEVERE SEPSIS / SEPTIC SHOCK

    SIRS-(Systemic Includes 2 or more of the following


    Inflammatory Temperature 100.4 or 96.8
    Response
    Heart Rate 90/min (caution: Meds that reduce HR and pacemakers)
    Syndrome)
    Respiratory Rate 20 breaths/min or PaCO2 < 32 or mechanically ventilated
    WBC count 12 or 4 or >10% bands
    SEPSIS SIRS + Confirmed or suspected infection.
    SEVERE Sepsis + Organ Hypoperfusion or Dysfuntion
    SEPSIS Hypoperfusion:
    o Elevated LA
    o Oliguria
    o Poor Capillary Refill
    o AMS
    Dysfunction:
    o Acute Renal Failure
    o Thrombocytopenia, DIC
    o ARDS
    o Hyperbilirubinemia
    o Delirium
    SEPTIC Sepsis + Refractory Hypotension
    SHOCK (Unresponsive to a fluid challenge of 30ml/kg)
    Systolic B/P < 90
    MAP < 65
    Vaopressors
    Early Goal Directed Therapy
    3 Hour 6 hour
    1. Blood Cx x 2/ Urine Cx / Sputum Cx before 1. MAP > 65
    2. Antibiotics 2. ScVO2 70%
    3. Lactic Acid & Procalcitonin 3. CVP 8-12
    4. 30ml/kg NS bolus for hypotension or LA 4 4. Urine Output 0.5ml/kg/hr

    If still hypotensive start Vasopressors


    NorepinephrineEpinephrine
    Vasopressin or DopamineDobutamine

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