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  • Acetyl Coa + Acetoacetyl Coa: Dimethylallyl Pyrophosphate

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    Merie Santia
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    The document outlines the mevalonate pathway and how the drug simvastatin works. It shows acetyl CoA and acetoacetyl CoA entering the pathway and being converted to HMG-CoA by HMG-CoA synthase. HMG-CoA is then converted to mevalonate by HMG-CoA reductase, which is inhibited by simvastatin, blocking cholesterol synthesis. Mevalonate goes on to create intermediates that lead to cholesterol, ubiquinone, dolichol, and protein prenylation products through further enzymatic conversions.

    Original Description:

    KOLESTEROL

    Original Title

    biosintesis kolesterol

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    The document outlines the mevalonate pathway and how the drug simvastatin works. It shows acetyl CoA and acetoacetyl CoA entering the pathway and being converted to HMG-CoA by HMG-CoA synthase. HMG-CoA is then converted to mevalonate by HMG-CoA reductase, which is inhibited by simvastatin, blocking cholesterol synthesis. Mevalonate goes on to create intermediates that lead to cholesterol, ubiquinone, dolichol, and protein prenylation products through further enzymatic conversions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    16 views1 page

    Acetyl Coa + Acetoacetyl Coa: Dimethylallyl Pyrophosphate

    Uploaded by

    Merie Santia
    The document outlines the mevalonate pathway and how the drug simvastatin works. It shows acetyl CoA and acetoacetyl CoA entering the pathway and being converted to HMG-CoA by HMG-CoA synthase. HMG-CoA is then converted to mevalonate by HMG-CoA reductase, which is inhibited by simvastatin, blocking cholesterol synthesis. Mevalonate goes on to create intermediates that lead to cholesterol, ubiquinone, dolichol, and protein prenylation products through further enzymatic conversions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    Acetyl CoA + Acetoacetyl CoA

    HMG CoA
    Synthase

    HMG CoA
    HMG CoA Simvastatin
    Reductase

    Mevalonate

    Mevalonate phyrophosphate

    Isopentenyl Pyrophosphate Dimethylallyl


    Pyrophosphate

    Geranyl Pyrophosphate
    Prenyl
    Transferase

    Ubiquinone Farnesyl Pyrophosphate Geranyl-Geranyl


    Pyrophosphate
    Squalen
    Dolichol synthetase
    Farnesyl
    Transferase Geranyl-
    Squalene Geranyl
    Transferase

    Protein Geranyl
    Protein Farnesylation
    Geranylation
    Cholesterol

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