Overview Notes (4) Related Modules

37

TRYPTOPHAN

Tryptophan :Chemistry 00:02:16

CH,--H
coOH

Benzene Pyrole
ring H
ring

Indole Ring
Aromatic amino acid
" Esserntial amino acid
" Both Ketogenic gucogenic
’ Anabolic fote
Tryptaphan (Trp)
QARTase
-Tryptophan/ myptoghan
Niacin Serotonin melatonin
pyrrolase /oygenase
e) ryptoghan
tapubhuyan39332@gmail.c.. hydroxinse
hetogenie fate Ghucogenic fate

space
Actlve

Tryptophan : Metabolism catabolic fate 00:06:27

Catabolic fate : A/WA kunurenine anthraniate pathuay

Biochemistry v40 Marow 6.5- 2023

Page 1/4

MARK COMPLETE
Overview Notes (4) Related Modules

230 Proteins and 37

Amino acids

Tryptophan
Tryptophan Pyrrolase N Formy kynurenine
THFA(Tetra Hydro Folic Acic)
(Heme containing)
SFornyl THFA
Kyurenine
hynurenine hydroxyase
Require NADPH
3-OH Kynurenine
/nynureninase - Coenzyme - PLP (vt 6)
Alanine
3-OH Anthranilate

Glucogenie
fate GPRTase
Rate limiting step
NAD' pathuay hetogenic ate

QPRTase - Quinolinate Phospho Rbosul Transerase

Ine, deRciency-3oH ynrenine
Xarthurenic acid

bcreted in urine
Niacin pelagra like sumptoms.
ConB359T5a7df22be2e5370d693
’Ima o niacin.

Feedback
D Tryptophan : Metabolism - anabolic fate 00:14:36

" Serotonin:

Tetrahydrobiopterin
NADPH
Tryptoghan Tryptophan hyroajase S-OH Tryptophan
Aromaticaminoacid
co Dcarboauase
S-OH tryptamine Serotonn

Rocheistry - Maro 65223 Page 2/4

Overview Notes (4) Related Modules

37 Tryptophan 231

Degrades to 5-OH Indole acetic acid.

Functions of serotonin : Neuro transmitter.

Vasoconstriction, mood elevator, temperature requiation

gastro intestinal tract motility
Site ofsuthesis Argentain cels.

intestine, mast celis, platelets and brain

melatonin :
Synthesized in pineal gland.
Serotonin ’Acetyl serotonin
SAm methionine
SAH

methyl acety! serotonin

(melatonin)
Function : Biologjcal rhythm
" Neurotransmitter.

Carcinoid tumor/syndrome 00:20:17

Neuroendocrine tumor.
A/n/A aroentaffinoma.
Tumor of arqentafin cels :

‘ Synthesis of serotonin; Niacin sunthesis

Feedback Clinical eatures :
" Intermittent diarrhoea.
"Cutaneous Aushing due to ‘ tachyinins.
"Sweating .
636975aZdt22he2e5370d693
"
space
Active
Niacin’Pelagra symptoms.
like
Diagnoss ‘ Serum Serotonin
‘SHAA in a4 hr urine W=< Smg / daup.
Overview Notes (4) Related Modules

232 oteiris anc 37

Amint ciets

Hartnup's disease

Delect in absorpion ot trptopharn other neutral aneo

acids Pronm intestine renal tutbules.

intestine
eO4t - delectve
Tryptophan
635975a7df22bezées37Od8I3cer
Bacterial in urine

enzyme
Renal
Circulation
indogy
Compounds
*indigoblue Sustemie
Circulation
"Indicarn

" Tryptophan in cells ’ Serotonin and Niacin.

me sumptonm:Cutaneous photosensitivity
(fhotosensitive dermatis cue to nacn .
Neurologicalmanitestation ( serotonir):wicde based qat,
intermittent ataxia.
Diagnosis by Obermeyer Test Test for incican
Treatment Supplement NAD'
*Lipid soluble esters o trytophan
Drummond syndrome 00:20:17

Feedback
D * eOAT- Transporter (of tryptoghar at intestne
coded by SLCAAN9,
Dxummond sundrome 80AT Iis defective in intestine
tlue cdiaper suynrome