Cells (Abnormal RBCs) Size Nucleus Cytoplasm N/C Ratio Reference Interval

Pronormoblast 12 2 um Round; Dark blue 8:1 BM: 1%

Nucleoli (1-2); fine chromatin PB: 0%
Basophilic Normoblast 10 15 um Round; Dark blue 6:1 BM: 1-4%
Nucleoli 0-1; slightly condensed chromatin PB: 0%
Polychromatic Normoblast 10 12 um Round; Gray blue 4:1 BM: 10-20%
Nucleoli 0; quite condensed chromatin PB: 0%
Orthochromic Normoblast 8 10 um Round; Blue to Salmon 0.5:1 BM: 5-10%
Nucleoli 0; fully condensed chromatin PB: 0%
Polychromatic Erythrocyte 8 8.5 um Absent Blue to Salmon NA BM: 1%
PB: 0.5% - 2%
Erythrocyte 7 8 um Absent Salmon NA BM: NA
PB: Predominant cell
type

Erythrocyte: Variations in Size

Microcyte Normocyte Macrocyte Dimorphoc population of

Erythrocytes
Associated with: Normal Erythrocyte are Associated with: Associated with:
Iron def anemia approximately the same Liver disease Transfusion
Sideroblastic anemia size as the nucleus of a Vitamin B12 deficiency Myelodysplastic
Thalassemia minor small lymphocyte Folate deficiency syndromes
Chronic disease Neonates Vit. B12
(occasionally) Folate
Lead poisoning Iron deficiency early in
Some treatment process
hemoglobinopathies