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  • Animal Simulator - XcologyPro

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    Indra Rukmana
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    This document summarizes experiments on the effects of various drugs on isolated perfused frog hearts. It finds that adrenaline and calcium chloride have positive chronotropic and inotropic effects, increasing heart rate and contraction amplitude, while acetylcholine and potassium chloride have negative effects. Propranolol and atropine inhibit the actions of adrenaline and acetylcholine, respectively, but not calcium chloride or potassium chloride. Digoxin increases contraction amplitude and decreases heart rate in a hypodynamic frog heart perfused with low-calcium Ringer's solution.

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    This document summarizes experiments on the effects of various drugs on isolated perfused frog hearts. It finds that adrenaline and calcium chloride have positive chronotropic and inotropic effects, increasing heart rate and contraction amplitude, while acetylcholine and potassium chloride have negative effects. Propranolol and atropine inhibit the actions of adrenaline and acetylcholine, respectively, but not calcium chloride or potassium chloride. Digoxin increases contraction amplitude and decreases heart rate in a hypodynamic frog heart perfused with low-calcium Ringer's solution.

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    © All Rights Reserved
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    49 views11 pages

    Animal Simulator - XcologyPro

    Uploaded by

    Indra Rukmana
    This document summarizes experiments on the effects of various drugs on isolated perfused frog hearts. It finds that adrenaline and calcium chloride have positive chronotropic and inotropic effects, increasing heart rate and contraction amplitude, while acetylcholine and potassium chloride have negative effects. Propranolol and atropine inhibit the actions of adrenaline and acetylcholine, respectively, but not calcium chloride or potassium chloride. Digoxin increases contraction amplitude and decreases heart rate in a hypodynamic frog heart perfused with low-calcium Ringer's solution.

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    © All Rights Reserved
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    of 11

    Determination of the Effects of Drugs on Isolated and Perfused Frog Heart

    Recording
    Observation Table
    Conclusion
    Effect of Given Drugs on Isolated Frog Heart
    1) Adrenaline increases heart rate and increases the amplitude of contractions. This indicates the positive
    inotropic and positive chronotropic effects of adrenaline

    2) Acetylcholine decreases heart rate and decreases the amplitude of contractions. This indicates the
    negative inotropic and negative chronotropic effects of Acetylcholine.

    3) Potassium chloride decreases the heart rate and decreases the amplitude of contractions. This
    indicates the negative inotropic and negative chronotropic effects of Potassium chloride.

    4) Calcium chloride increases heart rate and increases the amplitude of contractions. This indicates the
    positive inotropic and positive chronotropic effects of Calcium chloride.
    Determination of the Effects of Drugs on Isolated and Perfused Frog Heart
    Recording
    Observation Table
    Conclusion
    Effects of Antagonists on the Actions of Agonists on Isolated and Perfused Frog
    Heart

    1) Propranolol inhibits the positive inotropic and positive chronotropic effects of Adrenaline.

    2) Atropine inhibits the positive inotropic and positive chronotropic effects of Acetylcholine.

    3) Propranolol and Atropine do not affect the actions of Calcium chloride and Potassium chloride on frog
    heart.
    Observation Table
    Conclusion
    Effect of Cardiotonics on Hypodynamic Frog Heart
    Perfusion of isolated frog heart with modified Ringer solution (containing 1/4th of Calcium chloride)
    reduces the amplitude of contraction of heart, whereas, administration of Digoxin solution increases the
    amplitude of contraction and reduces heart rate.

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