G.S.N. Koteswara Rao, M.Pharm., D.D.D., D.C.T., (Ph.

D), (MBA)
Asst. Professor,
RAGHU College of Pharmacy,
Visakhapatnam. Pharmacokinetics Solved Problems
www.raghupharmacy.com www.pharmainfo.net/og/rcp/downloads

Pharmacokinetics
Bioavailability
Solved Problems
by G.S.N.K.Rao {Eswar}

PROBLEM-7:
AUC values of penicillin up on i.v administration of 50 mg and oral administration of 100 mg tablet
were found to be 70 and 90 respectively.
Calculate:
a. Absolute Bioavailability of penicillin.
b. Relatively Bioavailability of penicillin from tablet based on penicillin suspension whose dose is
100 mg and AUC is 95.

SOLUTION-7:
a. Calculate Absolute Bioavailability of penicillin.
Given,
i.v. dose of penicillin, Div = 50 mg
Oral dose of penicillin tablet, Doral = 100 mg
AUC of iv administered penicillin, [AUC]iv = 70 mg. hr/lt
AUC of oral administered penicillin, [AUC]oral = 90 mg. hr/lt
Absolute Bioavailability, F = ?
Formula:
[AUC]oral D i.v
Absolute Bioavailab ility, F = x 100
[AUC]i.v D oral
90 x 50 4500
F= = = 0.64 x 100 = 64%
70 x 100 7000

b. Calculate Relatively Bioavailability of penicillin from tablet based on penicillin suspension

whose dose is 100 mg and AUC is 95.
Dose of penicillin tablet, Dtest = 100 mg
Dose of penicillin suspension, Dstd = 100 mg
AUC of penicillin tablet, [AUC]test = 90 mg. hr/lt
AUC of penicillin suspension, [AUC]std = 95 mg. hr/lt
Relative Bioavailability, Fr = ?
Formula:
[AUC]test D std
Absolute Bioavailab ility, Fr = x 100
[AUC]std D test
90 x 100 9000
Fr = = = 0.95 x 100 = 95%
95 x 100 9500

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G.S.N. Koteswara Rao, M.Pharm., D.D.D., D.C.T., (Ph.D), (MBA)
Asst. Professor,
RAGHU College of Pharmacy,
Visakhapatnam. Pharmacokinetics Solved Problems
www.raghupharmacy.com www.pharmainfo.net/og/rcp/downloads

PROBLEM-8:
Following data is obtained for 4 formulations of pentoxyifylline in volunteers of average weight 50 kg.

Drug Product Dose (mg/kg) AUC (mg. hr/lt)

i.v. solution 1.2 450
oral solution 4.0 822
oral capsule 4.0 736
oral S.R. tablet 8.0 1040

SOLUTION-8:
Given data:
Drug Product Dose Dose in AUC (mg. hr/lt)
(mg/kg) mg /50kg
i.v. solution 1.2 Di.v. = 1.2 x 50 = 60 [AUC]i.v. = 450
oral solution 4.0 Dsol = 200 [AUC]sol = 822
oral capsule 4.0 Dcap = 200 [AUC]cap = 736
oral S.R. tablet 8.0 DSR = 400 [AUC]SR = 1040

a. What is the absolute bioavailability of the drug from capsule?

[AUC]cap Di.v. 736 x 60 44,160

F= = = = 0.49 x 00 = 49%
[AUC]i.v. Dcap 450 x 200 90,000

b. What is the absolute bioavailability of the drug from S.R. tablet?

[AUC]S.R Di.v. 1040 x 60 62,400

F= = = = 0.346 x 00 = 34.6%
[AUC]i.v. DS.R. 450 x 400 1,80,000

c. What is the relative bioavailability of capsule against oral solution?

[AUC]cap Dsol 736 x 200 1,47,200

Fr = = = = 0.895 x 00 = 89.5%
[AUC]sol Dcap 822 x 200 1,64,400

d. What is the relative bioavailability of S.R. tablet against oral solution?

[AUC]S.R. Dsol 1040 x 200 2,08,000

Fr = = = = 0.632 x 00 = 63.2%
[AUC]sol DS.R. 822 x 400 3,28,800

e. Which solid formulation shows better bioavailability?

Bioavailability of capsule (49%) is more than S.R. tablet (34.6%).

Reference: Bio-Pharmaceutics and Pharmacokinetics by: Brahmankar

GOOD LUCK : V. Venkateswarlu

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