The IBSA Group -

Pharmaceutical research
and technology applied to
skin healthcare.
Founded by a group
of Swiss biologists
in 1945, IBSA –
Institute Biochimique SA
has gained a unique
experience in
pharmaceutical research
and technology.
IBSA’s corporate philosophy is focused on the development of a series of niche-
oriented proprietary technologies. Testimony to this philosophy are our core
products such as Flector, one of the first anti-inflammatory patches and market
leader of its kind, not to mention Sinovial (Rheumatology), Fostimon (Human
Reproduction) and Ialuset (Dermatology).
IBSA is now an established name, with highly specialized production plants
worldwide.
IBSA’s experience and competence in the pharmaceutical field have also
been applied to the development of hyaluronic acid-based medical devices in
orthopedic and respiratory areas as well as in dermatology and skin healthcare.
IBSA Farmaceutici Italia SRL, the Italian based subsidiary boasts high level
standards as a top quality manufacturer in the pharmaceutical, nutritional
products and medical device fields.

Of the 7 therapeutic areas in which IBSA specializes, the dermoesthetic area

(produced and managed in Italy) offers a complete range of products including
Viscoderm®, Viscoderm® Skinkò and Aliaxin® based on Hydrolift® Action.
Hydrolift® Action is an innovative and
exclusive therapeutic approach, aimed at
preventing and treating the physiological
reduction of hyaluronic acid in the skin,
restoring hydration, elasticity and skin tone.

Hydrolift® Action is an expression of the synergic action of the bio-regenerative and

mechanical lifting of skin depressions by Hyaluronic Acid, thanks to the combined use of
selected Hyaluronan of IBSA patented production, both natural and modified.
medical device Class III
for BIOCOMPLEMENTATION

Prevention of early signs of skin aging and maintenance of active cell trophism in the dermis.
The Skinkò and Skinkò E anti-aging complex contains more than 50
dermofunctional elements including hyaluronic acid, minerals, essential amino acids and vitamins.
Skinkò and Skinkò E acts on both the causes and the effects of skin
aging preserving the skin’s biological qualities and enhancing natural beauty by:
• Improving hydration and cell trophism
• Providing essential elements for skin restructuration
• Protecting against oxidative stress and harmful UV rays
The outcome is a younger looking healthier skin with improved skin tone, enhanced radiance and freshness.

MINERALS AMINO ACIDS VITAMINS

Ammonium, Calcium, Copper, Iron,
Magnesium, Manganese, Potassium,
Sodium, Tin, Zinc
Alanine, Arginine, Asparagine, Aspartic
Acid, Cysteine, Glutamic Acid, Glutamine,
Glycine, Histidine, Isoleucine, Leucine, Lysine,
Methionine, Phenylalanine, Proline, Serine,
Threonine, Tryptophan, Tyrosine, Valine
Biotin (Vit. B8), Calcium Pantothenate (Vit. B5),
Choline Chloride, Folic Acid (Vit. B9),
Inositol (Vit. B7), Nicotinamide (Vit. B3),
Pyridoxine (Vit. B6), Riboflavin (Vit. B2),
Thiamine (Vit. B1), Vitamin B12

2mg HA + anti-aging complex

5ml vial of injectable solution

32mg HA + anti-aging complex

5ml vial of injectable solution

Skinkò and Skinkò E are applied by injection into the superficial layer
of the face, neck, décolleté and hands. They are also suited for use on extended body areas.
medical device Class III
for BIORESTRUCTURATION

Promotion of skin renewal through intradermal injections of natural hyaluronic acid stimulating the
activation of fibroblasts and synthesis of new collagen.
prevents and counteracts the effects of reduced hyaluronic acid for in depth repair of
structures supporting skin tissue.
significantly improves skin hydration and elasticity with an excellent tolerability
is available in three different concentrations of hyaluronic acid designed to meet all
patients needs.

0.8%
Hyaluronic acid sodium salt
Concentration 0.8% (8 mg/ml)
Indicated for particularly thin,
delicate skin areas and for
prevention treatments.

1.6%
Hyaluronic acid sodium salt
Concentration 1.6% (16 mg/ml)
Indicated for biorevitalization
treatments of face, neck,
décolleté, hands and larger
body areas for prevention,
restructuring and maintenance.

2.0%
Hyaluronic acid sodium salt
Concentration 2.0% (20 mg/ml)
Indicated for restructuring
treatments of the mid to deep
dermis, in areas of thick skin,
and to obtain a long-term filler
effect in some wrinkle types.
HIGH VOLUME
MaXXimize Volume, Versatility and Comfort,
for even better and earlier aesthetic results

IDEAL FOR ADVANCED AGING TREATMENTS

50mg of Hyaluronic Acid in 2,5 ml - 1 prefilled syringe
+ 2 thin wall 30G needles

IDEAL FOR EXTENDED AREAS

24mg of Hyaluronic Acid in 1,5 ml - 3 prefilled syringe
+ 6 30G needles

PERFECT FOR ENHANCED HYDRATION

16mg of Hyaluronic Acid in 2ml - 1 prefilled syringe
+ 2 30G needles
medical device Class III
for DERMAL RESHAPING
Global rejuvenation solutions enhancing natural facial beauty
Four different formulations, with specific, differentiated visco-elastic properties, are the result of
IBSA research, which is capable of exploiting to the maximum the clinical effectiveness combi-
ning hyaluronic acid with different molecular weights, differentiating their behaviour by altering their
cross-linking degree.
IDEAL FOR DERMAL REMODELLING
Replenishing facial fullness, with natural and well
defined contour.

IDEAL FOR TREATING THE MOST COMMON

FACIAL BEAUTY FLAWS
May also be used to restore localised volume and
for touch-ups.

SPECIFIC FOR LIP TREATMENT

The particular structure of the gel guarantees high
resistance to mechanical stress and excellent diffusion
in the labial mucosa.

VOLUME & CONTOUR

Optimal lifting capacity makes it the ideal product for
subcutaneous implants, restoring facial volume.

CHARACTERISTICS

GEL TYPE monophasic monophasic monophasic monophasic

HYALURONIC ACID:
1000 kDa, 2000 kDa
MOLECULAR WEIGHTS

FREE BDDE CONTENT

EXTRUSION STRENGTH
(NEEDLE)
 IBSA’S MULTI APPROACH TO SKIN AGING
0.8% 1.6% 2.0%
trio

Reshaping &
Hydration + Hydration + Deep Mid & Deep Volume & Fine
Treatment Hydration Biorestructuration Restoration Mid Volume/Cheek,
Trophism Trophism Biorestructuration Depressions of Lines /Lip &
goal / area Face & Body Face & Body & Lower Third of Chin & Jawline
Face & Body Face & Body Face & Body Skin Perioral Area
the Face
Skin type Thin skin Normal skin Thin skin Normal skin Thick skin All skin types All skin types All skin types All skin types
Moderate/
Photo-aging Mild/Moderate Moderate Mild Moderate Moderate Moderate Not applicable Not applicable
Severe

HA 0.40mg/ml 6.40mg/ml 25mg (22.5

concentration + antiaging + antiaging 8mg/ml 16mg/ml 20mg/ml Crosslinked + 25mg/ml 25mg/ml 25mg/ml
complex complex 2.5 natural)
Packaging 10x5ml 10x5ml 1x1ml -1x2ml 1x1ml - 3x1.5ml 1x1ml - 1x2.5ml 2 x 1ml 2x 1ml 2 x 1ml 2 x 1ml
point by point, point by point,
linear/
Suggested nappage, nappage, linear/ linear/ linear/ linear/
point by point retrograde/fan bolus
technique transdermal transdermal retrograde retrograde retrograde retrograde
technique
system system
27G TW x
12.7mm / 27G 27G TW x 27G TW x 25G TW x
NEEDLE 30G x 1/2” 30G x 1/2” 30G x 1/2” 30G x 1/2” 30G x 1/2”
TW x 19mm 12.7mm / 27G 12.7mm / 30G 12.7mm / 25G
(0.3x12mm)” (0.3x12mm)” (0.3x12mm)” (0.3x12mm)” (0.3x12mm) TW
Optional TW x 19mm TW x 12.7mm TW x 19mm
cannula

•• ••• ••••• ••••• ••••• •••• •• ••• •

• •• ••• •••• •••• •••••
Repair and
Prevention Prevention Prevention Repair and
maintenance of
of early signs of early signs of early signs maintenance of
the physiological
of aging of aging of aging the physiological Dermal Correction of
conditions of Definition of the
Radiance Radiance Enhanced conditions of remodelling, deep wrinkles Volume recovery
healthy skin vermillon border,
Improvement Improvement hydration healthy skin redistribution of (nasolabial folds, for extended
INDICATION/ in cases of lip volume, oral
1 treatment 1 treatment 1 treatment 1 treatment facial volume, marionette lines) areas such as
PROTOCOL advanced aging commissures,
every 30 days every 30 days every 20 days every 20 days symmetry, skin and volume cheek/chin
1 treatment perioral wrinkles
(repeat 3x) (repeat 3x) (repeat 3x) (repeat 4x) Wait tone, firmness, redefinition of and jawline
every 20 days and facial fine
Wait 1 month- Wait 1 month- Wait 1 month- 1 month- elasticity targeted areas remodelling
(repeat 4x) lines
1more treatment 1 more treatment 1 more treatment 1 more treatment (cheek/chin)
Wait 1 month-
Repeat twice/ Repeat twice/ Repeat twice/ Repeat twice/
1 more treatment
year year year year
Repeat twice/year

INJECTION Epidermis and Mucosa and Subdermis and

LAYER Epidermis Reticular Dermis Reticular Dermis Mid Dermis Mid Dermis Deep Dermis
Papillary Dermis Mid Dermis Supraperiosteal

PREVENTION – BIOCOMPLEMENTATION REPAIR – BIORESTRUCTURATION RESHAPING

1.6% 0.8%
trio
stratum CORNEUM

Epidermis
0,07 mm - 0,12 mm
BASAL LAYER
PAPILLARY DERMIS

RETICULAR DERMIS

MID DERMIS dermis

1,0 mm - 4,0 mm
LOWER RETICULAR DERMIS

SUBCUTANEOUS TISSUE
SUBCUTIS

2.0%
 IBSA Farmaceutici Italia S.r.l
Via Martiri di Cefalonia 2 - 26900 Lodi - Italy
www.ibsaderma.com