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AnalgesiaGuidelinesPaediatric 2017 PDF
AnalgesiaGuidelinesPaediatric 2017 PDF
V5.1
JUNE 2017
Table of Contents
3. Scope
3.1. This policy applies to anyone who looks after children within RCHT.
4. Definitions / Glossary
4.1.
PCA- Patient Controlled Analgesia
NCA- Nurse Controlled Analgesia
TTO- Tablets to Take Out
NSAID- Non Steroidal Anti-Inflammatories
IV- Intravenous
5.2.
Dr Julian Berry
Medicines Practice Committee
Acute Paediatric Pain Service
Anaesthetists (Paediatric)
Clinical staff members
1
Morton, N S.(2007) Arch Dis Child Educ Pract Ed 92: ep14-ep19
2
Anderson, B J. (1998) What we don’t know about Paracetamol in children. Paediatric Anaesthesia ;8:451–60
3
Kokki, H. (2003) Non steroidal anti-inflammatory drugs for postoperative pain: a focus on children. Paediatric Drugs; 5:103–23.
4
Ippokratis Pountos, Theodora Georgouli, Giorgio M. Calori, and Peter V. Giannoudis (2012). Do Nonsteroidal Anti-Inflammatory Drugs
Affect Bone Healing? A Critical Analysis. The Scientific World Journal, Volume 2012, Article ID 606404.
5
MHRA (2013) Drug safety update. MHRA; Volume 6, Issue 12.
6
Morton, N. (1997) Paediatric Patient Controlled Analgesia. Paediatric Perinat Drug Ther; 1:9–13.
Paediatric Analgesia Guidelines
Page 4 of 23
6.2. Guidelines for Paediatric Analgesia
Whenever possible use a pre-prescribed weight-based EPMA protocol: ‘Paed Pain (ward), ‘Paed Peri’ (theatre) or
‘Femur Child’ (# femur in ED).
Adequate and regular dosing is essential. Use the oral route if pain is not severe. Use parenteral administration if the
drug can only be used this way or if enteral administration has failed or ineffective.
Prescribe ONE drug from each colour only.
If more than two IV opiate doses are required, consider IV infusion/PCA/NCA with guidelines.
Contact Paediatric Pain Team on bleep 2283 (office hours) or Senior Anaesthetic Trainee (bleep3513) for advice
or help.
DRUG ROUTE DOSE ESCALATING
ANALGESIA
Intravenous-
<6 months 100 micrograms/kg 6 hourly
>6 months 100 micrograms/kg 4 hourly
TTO’s of Oramorph-
>12 months- 100 micrograms/kg 6 hourly
If OSA/altered respiratory drive-
50micrograms/kg 6 hourly
INTRANASAL- ONCE ONLY
Diamorphine Intranasal spray- See separate guideline on intranet
720micrograms/spray intranetanaestheticguidelinespaediatric pain
1600micrograms/spray
RESPIRATORY DEPRESSION
Give oxygen, contact paediatric or ITU consultant. Consider PERT call.
< 12 years- Naloxone 10micrograms/kg IV bolus and repeat if necessary. If no response, give subsequent doses of 100
micrograms/kg (max 2mg)
> 12 years- Naloxone 100micrograms IV bolus and repeat if necessary. If no response, give subsequent doses in
increments of 100micrograms every 2 minutes if required (max dose 10mg).
FIRST-LINE ANTI-EMETIC
Ondansetron Intravenous 0.1mg/kg 8 hourly Can cause severe constipation.
See BNFC for Orally <4 years- 2mg 8 hourly May be ineffective in opioid induced nausea
alternatives >4 years- 4mg 8 hourly and vomiting.
CONSIDER ENTONOX FOR PROCEDURAL PAIN RELIEF
Contraindications
Necrotising enterocolitis.
Suspected hyperglycaemia.
Dose
Must be prescribed on their drug chart.
The dose is administered onto the baby’s tongue approximately 2 minutes prior to the
procedure. After administration the baby should be given a dummy or comforter to suck on
as this can potentiate the analgesic effect of sucrose. The effect may last for approximately
10 minutes.
There is no data regarding repeated doses or long term effects of using sucrose.
Holsti, L. and Grunau, R.E. (2010) Considerations for using sucrose to reduce procedural pain in
preterm infants, Pediatrics, 125(5) pp 1042-1047.
Stevens, B., Yamada, J., Lee, G. and Ohlsson, A. (2013) Sucrose for analgesia in newborn infants
undergoing painful procedures, Cochrane Database of Systematic Reviews; Cochrane Neonatal
Group, DOI: 10.1002/14651858.CD001069.pub4
Indications
First line treatment of severe pain in a child without IV access e.g.
Clinically suspected limb fractures
Painful dressings/burns
Procedural pain
Intranasal Diamorphine is usually effective within 5-10 minutes but allow 20 minutes
for maximum pain control. Analgesic effect lasts for up to 4 hours.
Oxygen saturation monitoring will be required once Diamorphine has been
administered and for 1 hour post administration.
Ensure that intravenous access is obtained as soon as possible.
Ensure that supplementary analgesia is prescribed (see coloured paediatric
analgesia dosing guideline) e.g. Paracetamol and NSAIDs.
Naloxone must be prescribed (see coloured paediatric analgesia dosing guideline).
*Child less than 12kg weight (unlicensed) only to be administered by a senior doctor.
Contraindications
Nasal trauma or epistaxis.
Decreased conscious level or head injury
Allergy to opiates.
Dose schedule
Dosing is based on weight
Preparation and administration-
Reconstitute, if required and date the bottle. Attach pump and nasal tip, remove
green collar and prime with 8 sprays.
Subsequent doses- Remove the green safety collar. Attached new nasal tip and
before use prime using 2 sprays.
Administer the required number of sprays (alternate nostrils).
Discard the used nasal tip and replace the green safety collar.
CD register- Record both the wastage from priming and the number of sprays in the
register.
720micrograms/spray 10-30kg
IV Morphine infusion
Any patient requiring a morphine infusion with complex medical or surgical needs requires
paediatric HDU.
Early discussion with Paediatric Consultant on call required before commencing case.
Young infants require reduced doses.
Prematurely-born neonates and infants must be discussed with a consultant anaesthetist.
The current pump to use is a PCAM pump with the handset removed. It should be
programmed with the background as ml/hr with no bolus.
Must have naloxone prescribed (see coloured paediatric analgesia dosing guideline).
TO MAKE INFUSION
Example For a 20kg child, use 20mg morphine and dilute to 50ml with normal saline.
20mg divided by 50ml = 0.4 mg/ml (or 400 micrograms/ml).
Infusion
regimes 0-1 months: maximum of 5 micrograms/kg//hour = max 0.25mL/hour
1-3 months: maximum of 10 micrograms/kg/hour = max 0.5mL/hour
Over 3 months: maximum of 40 micrograms/kg/hour = max 2mL/hour
Pumps are kept in recovery, need drug keys to unlock. Keys for PCA machines are kept
together with the controlled drug keys by the nurse in charge.
The default is set to 200 micrograms/ml, this needs adjusting depending on weight:
For use in 4 years and above, usually have the ability to understand and push the button.
LOCKOUT 5 minutes.
Pumps are kept in recovery, keys for PCA machines are kept together with the controlled
drug keys by the nurse in charge.
The default is set to 200 micrograms/ml, this needs adjusting depending on weight:
o To set rate, scroll down to continuous and alter the rate in mls
Use with constant background, and allows bolus for breakthrough and procedures.
Use on paediatric HDU only. Early discussion with Paediatric Consultant on call required
before commencing case.
Dose: 1mg/kg Morphine made up to 50ml with normal saline, example as above for
morphine.
Pumps are kept in recovery, need drug keys to unlock. Keys for NCA/PCA machines are
kept together with the controlled drug keys by the nurse in charge.
The default is set to 200 micrograms/ml; this will need adjusting, depending on weight:
o To set rate, scroll down to continuous and alter the rate in mls
Dose: 50 micrograms/kg Fentanyl made up to 50ml with normal saline (max 40kg).
Example For a 20kg child use 50 micrograms/ml Fentanyl and draw up 20mls (ie 2 large 500
micrograms amps), dilute with normal saline to 50ml: 1000 micrograms divided by
50ml = 20 micrograms/ml.
Maximum dose 50mls (i.e. 5 large 500microgram ampoules).
Dose: 50micrograms/kg Fentanyl made up to 50mls with Normal Saline (max 40kg).
LOCKOUT 10 minutes.
Pumps are kept in recovery, need drug keys to unlock. Keys for NCA/PCA machines are
kept together with the controlled drug keys by the nurse in charge.
The default is set to 10 micrograms/ml; this will need adjusting, depending on weight:
o To set rate, scroll down to continuous and alter the rate in mls
500micrograms Fentanyl (=10mls neat fentanyl) made up to 50mls with Normal saline
There is no per kilogram calculation
Dose: 10micrograms/ml
BOLUS 1ml
LOCKOUT 5 minutes
Pumps are kept in recovery, need drug keys to unlock. Keys for NCA/PCA machines are
kept together with the controlled drug keys by the nurse in charge.
Ensure oxygen available. Monitor for respiratory depression, sedation and itch
If patient BMI>30 calculate an ideal body weight using patient height-50th centile weight
chart (see page 17 or BNFc back page).
Dose
Practice points
Must have naloxone prescribed (see coloured paediatric analgesia dosing guideline).
Must have anti-emetics prescribed (see coloured paediatric analgesia dosing guideline).
Children require larger volume with lower concentrations of opiate to block dermatomes.
Continuous infusion rates of around 0.4mg/kg/hr are effective for children > 3 months.
Please complete a yellow paediatric acute pain audit form to ensure follow-up.
Infusion
Rate 0.2-0.4ml/kg/hr
Keys for epidural machines are kept together with the controlled drug keys by the nurse in
charge.
After switching on enter code
PROBLEM ACTION
Infusion rate too low On-call should give a bolus dose of epidural mixture and
increase rate.
Bolus dose is 0.25ml/kg of 0.25% Levobupivicaine, e.g. 0.25
x 20kg = 5mls of 0.25%.
A bolus of epidural mix can also be given, 0.25mls/kg. Press
and hold bolus, enter code, then amount, MAX 10ml.
Catheter not in epidural Check catheter site for leakage.
space, or kinked Consider removing and replacing with PCA.
Regular review of site.
Child may have full bladder Consider catheterisation.
Patchy Block Consider top-up in correcting position.
Remove and replace with PCA.
Witnessed catheter Clean the end of the catheter with 2% Chlorhexidine, allow
disconnection from filter. drying and holding the catheter with a sterile swab, cut the
catheter with a sterile scissors approximately 2 – 3 cm and
insert into the filter.
Un-witnessed catheter Epidural will require removal. If in doubt contact the Acute
disconnection from filter. Pain Team or 1st Call Anaesthetist
Side effects
Local anaesthetic toxicity. STOP infusion, contact Senior Anaesthetic Trainee bleep
Signs and symptoms: 3513 as an emergency.
Dizziness, blurred vision, Local anaesthetic rescue boxes are located in:
decreased hearing, tingling in General and trauma recovery.
mouth and lips, restlessness, Eden Ward
tremor, hypotension, bradycardia, ITU
arrhythmias, seizures, sudden loss
of consciousness.
Leg weakness/ motor block Stop infusion, monitor sensory and motor block every 15
minutes, contact on call anaesthetist or pain team, the
DENSE MOTOR BLOCK IS concern is epidural haematoma.
ABNORMAL! See flow chart on next page.
Contact the
Increasing leg weakness? Paediatric Pain
Motor block score 3 or 4 Team or Senior
Anaesthetic Trainee
Yes bleep 3513 to inform
Routine them of the situation
observations
Switch epidural
Yes infusion off
Recommence
epidural Reassess leg
infusion strength every
30 minutes
Yes
No
No
Yes
The table below shows the mean values for weight, height and gender by age; these values have
been derived from the UK-WHO growth charts 2009 and UK1990 standard centile charts, by
extrapolating the 50th centile, and may be used to calculate doses in the absence of actual
measurements. However, the child’s actual weight and height might vary considerably from the
values in the table and it is important to see the child to ensure that the value chosen is
appropriate. In most cases the child’s actual measurement should be obtained as soon as possible
and the dose re-calculated.
2 months 5.4 58
3 months 6.1 61
4 months 6.7 63
6 months 7.6 67
1 year 9 75
3 years 14 96
5 years 18 109
7 years 23 122
10 years 32 138
12 years 39 149
14 year-old boy 49 163
9.2. Any revision activity is to be recorded in the Version Control Table as part of
the document control process.
Dr Julian Berry
July 11 V1.0 Initial Issue
Lead For APPS
Dr Julian Berry
Dec 11 V2.0 Additional guidance introduced.
Lead for APPS
Dr Julian Berry
Sept 13 V3.1 Change in practice regarding Codeine
Lead for APPS
Dr Julian Berry
Jan 15 V4.0 Update of guidance
Lead for APPS
Dr Julian Berry
July 17 V5.1 Change to intranasal Diamorphine priming
Lead for APPS
All or part of this document can be released under the Freedom of Information
Act 2000
This document is to be retained for 10 years from the date of expiry.
This document is only valid on the day of printing
Controlled Document
This document has been created following the Royal Cornwall Hospitals NHS Trust
Policy on Document Production. It should not be altered in any way without the
express permission of the author or their Line Manager.
4. *How will you Monitor through audit, incident reporting and case discussions at
measure the governance meetings
outcome?
Are there concerns that the policy could have differential impact on:
Equality Strands: Yes No Unsure Rationale for Assessment / Existing Evidence
Age
Sex (male,
female, trans-gender /
gender reassignment)
Race / Ethnic
communities
/groups
Disability -
Learning disability,
physical
impairment, sensory
impairment, mental
health conditions and
some long term health
conditions.
Religion /
other beliefs
Marriage and
Civil partnership
Pregnancy and
maternity
Sexual
Orientation,
Bisexual, Gay,
heterosexual, Lesbian
You will need to continue to a full Equality Impact Assessment if the following have
been highlighted:
You have ticked “Yes” in any column above and
No consultation or evidence of there being consultation- this excludes any policies which have
been identified as not requiring consultation. or
9. If you are not recommending a Full Impact assessment please explain why.
No areas indicated
Keep one copy and send a copy to the Human Rights, Equality and Inclusion Lead
c/o Royal Cornwall Hospitals NHS Trust, Human Resources Department, Knowledge Spa,
Truro, Cornwall, TR1 3HD
This EIA will not be uploaded to the Trust website without the signature of the
Human Rights, Equality & Inclusion Lead.
Signed _ ____________