Flupenthixol

About Flupenthixol
First-Generation Antipsychotic, a thioxanthene derivative, Typical Antipsychotic.
Mechanism of Action of Flupenthixol
Flupenthixol exerts its antipsychotic action by blocking post synaptic Dopamine receptor
in the limbic system. It is a potent antagonist of D1&D2 receptors.
Flupenthixol is an alpha adrenergic receptor blocker and depresses many hypophyseal
and hypothalamic hormones. It also blocks Prolactin inhibitory factor (PIF) and results in
hyperprolactinemia.
Pharmacokinets of Flupenthixol
Absorption: Flupenthixol is slowly and incompletely absorbed after oral administration.
Its bioavailability is only 50 % because it undergoes first pass metabolism. Distribution:
It is distributed widely in the body in protein bound form. Metabolism: It is metabolised
in the liver to inactive metabolites. Excretion: It is excreted mainly through faeces and
small amount through urine.

Melitracen
About Melitracen
A tricyclic antidepressant, Antidepressant.
Mechanism of Action of Melitracen
Melitracen acts by decreasing reuptake of Norepinephrine and Serotonin at the synapse
resulting in high concentration of these neurotransmitters at the post-synaptic end. Thus it
produces its antidepressant effect.
Pharmacokinets of Melitracen
Absorption: It is well absorbed orally.