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  • LN CP Slope Intercept K X (AUC) 0-tn Auct (AUC) - T: CP (MG/L) Waktu (Jam) N

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    Desy Purnamasari
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    This document contains pharmacokinetic data from an experiment measuring drug concentration (Cp) over time. It includes the calculated elimination rate constant (Kel), area under the curve (AUC) from time 0 to each timepoint, and the product of Kel and AUC which is used to determine fraction of drug remaining in the body (Ab/Ab∞) over time. The slope of the linear regression of the ln-transformed fraction remaining values over time gives the absorption rate constant (Ka).

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    Metode wagner-nelson

    Original Title

    Wagner Nelson Method

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    This document contains pharmacokinetic data from an experiment measuring drug concentration (Cp) over time. It includes the calculated elimination rate constant (Kel), area under the curve (AUC) from time 0 to each timepoint, and the product of Kel and AUC which is used to determine fraction of drug remaining in the body (Ab/Ab∞) over time. The slope of the linear regression of the ln-transformed fraction remaining values over time gives the absorption rate constant (Ka).

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    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
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    3 views2 pages

    LN CP Slope Intercept K X (AUC) 0-tn Auct (AUC) - T: CP (MG/L) Waktu (Jam) N

    Uploaded by

    Desy Purnamasari
    This document contains pharmacokinetic data from an experiment measuring drug concentration (Cp) over time. It includes the calculated elimination rate constant (Kel), area under the curve (AUC) from time 0 to each timepoint, and the product of Kel and AUC which is used to determine fraction of drug remaining in the body (Ab/Ab∞) over time. The slope of the linear regression of the ln-transformed fraction remaining values over time gives the absorption rate constant (Ka).

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Waktu

    (jam)
    Cp (mg/L) Ln Cp Slope Intercept Kel AUCtn-1-tn (AUC)0-tn k x (AUC)0-tn
    0 0 Err:502
    0.25 0.901 -0.10425 0.733084 -0.19738 -0.73308 3.604 3.604 -2.6420339201
    0.5 1.309 0.269263 8.84 12.444 -9.1224944787
    0.75 1.526 0.42265 11.34 23.784 -17.435664471
    1 1.577 0.455524 12.412 36.196 -26.534700269
    1.5 1.429 0.356975 6.012 42.208 -30.941999916
    3 0.964 -0.03666 1.595333333 43.80333333 -32.111512896
    6 0.384 -0.95711 0.449333333 44.25266667 -32.440911872
    12 0.062 -2.78062 0.074333333 44.327 -32.495404432
    18 0.01 -4.60517 0.012 44.339 -32.504201438
    24 0.002 -6.21461 0.002 44.341 -32.505667605
    Cp + k x (AUC)0-tn
    Ab/Ab∞ 1-Ab/Ab∞ Ln 1-Ab/Ab∞ slope Ka

    -1.74103 0.053561 0.9464390659 -0.055048689 -1.96252 1.962523


    -7.81349 0.240373 0.7596267035 -0.274928146
    -15.9097 0.489443 0.5105572153 -0.672252571
    -24.9577 0.767795 0.2322046551 -1.460136162
    -29.513 0.907934 0.0920660275 -2.385249269
    -31.1475
    -32.0569
    -32.4334
    -32.4942
    -32.5037

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