neoBona, which is based on the analysis of the actual DNA

of fetal placental origin provides greater confidence for

parents as false positives are reduced to less than 0.1% Ghana Ltd. ISO:15189:2012

There is confidence that chromosomal abnormalities can

be detected early in pregnancy. The test is non-invasive
and poses no risks to the pregnancy.

Experience: Synlab is the European leader in prenatal Results You

diagnostic tests to date. neoBona is the result of 10+ years Can Trust...
of experience. Medlab will coordinate the collection and will
provide the service in Ghana as a member of the Synlab group.

Who can have the test?

T he test is suitable for any

pregnant woman with a neoBona
gestation period of 10 the Next generation of NIPT
weeks or more.
Prenatal diagnostics
neoBona can be performed in cases

C
of assisted reproduction, including hromosomal abnormalities occurs in approximately 1% of
IVF through egg donation. neoBona all neonates at birth. There is an increased risk with
is suitable for twin examination. increasing maternal age, of a disorder of the chromosome
number. For example the likelihood of Down's syndrome or Trisomy
What is the process 21 increases exponentially after age 35.

O nce you have taken an independent personal decision that

you want to have the NIPT prenatal test performed, you
will be asked to sign a consent form and your blood sample
Combined Screening

can be taken from a vein in your arm. The result should be available
within 1 week.
Your contacts at Medlab:
Head-ofce: 0302 769 680 / 0302 765 335
0540 124 371 / 0540 124 372
E-mail: customercare@medlab.com.gh
C
ombined screening was used to indicate this risk. This
screening test incorporates maternal age, biochemical tests
(E3, AFP, BHCG, Inhibin and PAPP-A) and ultrasound
parameters. Maternal height, weight and gestational age should be
recorded. Sensitivity is 90% that is 10 in 100 are missed and specificity
is 95% that is 5% are false positives.

The Gold Standard
I nvasive diagnostics allows for the earliest possible sampling of fetal
tissue to perform genetic tests. The great advantage of prenatal
chromosomal analysis is the fact that the
percentage of errors is very low. However, the
methods used are invasive. Amniocentesis at 15
weeks is followed by karyotyping. Mothers may
have complications, such as contractions, bleeding,
infection and leakage of amniotic fluid. The
spontaneous abortion rate is 0.5% - 1%. Therefore
these methods were reserved for those at greatest
risks. The indications for invasive procedure
includes:
Maternal age > 35
Previous pregnancy with a chromosome defect
Familial genetic disorders.
Suspicious ultrasound.
Suspicious combined screening result.
Non-invasive prenatal testing (NIPT)
N on-invasive prenatal testing (NIPT) was introduced after
the recognition that cell free fetal DNA
was circulating in the maternal blood.
Extraction and analysis of this should therefore
give an insight into the genes of the child.The great
advantage of this test method is that it is non
invasive and does not pose a risk of miscarriage. It
has a high accuracy rate and eliminates false
positive results. It is a new option in prenatal
screening for (trisomy 21) and other common fetal
Cell-free fetal DNA
chromosomal conditions (trisomies 18 and 13).
Female
Free maternal DNA
n
About neoBona
eoBona is a new generation of non-invasive prenatal
testing developed by integrating the most innovative
technologies. It analyses the cell-free fetal DNA in the
mother's blood using massive parallel sequencing with paired-end
reads. It differentiates between cell-free DNA of fetal and maternal
origin.A low fetal fraction may provide false negative results.
It uses counting statistics to see if more than the expected number
of counts is mapped to the target chromosome. Fragment size
statistics is determined. The two are combined to create a score.
This score is used for the analysis.
In the presence of a result consistent with an abnormality, Synlab
offers genetic counselling to the physician and amniocentesis is
reduced to 1% of previous figures.
Advantages of neoBONA 2015
over Harmony 2012
Fetal Fraction - Unlike other prenatal tests, neoBona
measures the fraction of cell-free fetal DNA in the sample,
improving the reliability of the result
Technology - Next Generation sequencing.
No amplification, hence less computing power needed
therefore it is cheaper
Professional Counselling - neoBona is the only prenatal
test available that has a support team of 600 medical
professionals and geneticists from the Synlab group that is
available to support the clinician
Accuracy – False positives are eliminated. Specificity –
99.9% and Sensitivity – 99%