GENES UPREGULATED

log2 fold
Name Gene Symbol Location Type(s)
change
NADPH oxidase 3 NOX3 cytoplasm enzyme 13.21
De-etiolated homolog 1 (Arabidopsis) DET1 nucleus other 10.97
plasma transmembrane
Patched 2 PTCH2 10.9
membrane receptor
Wingless-type MMTV integration site extracellular
WNT6 other 6.74
family, member 6 space
Zinc finger, matrin-type 4 ZMAT4 nucleus other 5.02
Retinoic acid induced 2 RAI2 unknown other 4.75
Dual specificity phosphatase 18 DUSP18 cytoplasm phosphatase 4.69
transcription
Transcription factor B1, mitochondrial TFB1M cytoplasm 4.58
regulator
MAP/microtubule affinity-regulating kinase 1 MARK1 cytoplasm kinase 4.30
extracellular
Interleukin 20 IL20 cytokine 4.29
space
Fatty acyl CoA reductase 2 FAR2 cytoplasm enzyme 4.16
transcription
Ets homologous factor EHF nucleus 4.09
regulator
SH3-domain GRB2-like 3 SH3GL3 cytoplasm other 4.06
2'-5'-oligoadenylate synthetase 1, 40/46kDa OAS1 cytoplasm enzyme 4.05
plasma
Synaptotagmin XIII SYT13 transporter 3.85
membrane
Aldehyde oxidase 1 AOX1 cytoplasm enzyme 3.78
plasma
G protein, alpha inhibiting activity GNAI1 enzyme 3.78
membrane
FXYD domain containing ion transport plasma
FXYD5 ion channel 3.75
regulator 5 membrane
Cytochrome c oxidase subunit VIIb2 COX7B2 unknown unknown 3.73
Wingless-type MMTV integration site extracellular
WNT10A other 3.60
family, member 10A space
Interferon, alpha-inducible protein 6 IFI6 cytoplasm other 3.35
transcription
Sp6 transcription factor SP6 nucleus 3.35
regulator
Acyl-CoA oxidase 2, branched chain ACOX2 cytoplasm enzyme 3.31
extracellular
Transforming growth factor, beta 2 TGFB2 growth factor 3.22
space
extracellular
Interleukin 24 IL24 cytokine 3.15
space
GABA(A) receptor-associated protein like
GABARAPL1 cytoplasm other 2.54
1
FBJ murine osteosarcoma viral oncogene transcription
FOS nucleus 2.41
homolog regulator
Laminin, beta 1 LAMB1 extracellular other 2.37
space
transcription
Nuclear receptor coactivator 4 NCOA4 nucleus 2.09
regulator
Phospholipase D1, phosphatidylcholine-
PLD1 cytoplasm enzyme 2.09
specific
plasma
v-Erb-b2 ERBB2 kinase 2.05
membrane
extracellular
Fibroblast growth factor 11 FGF11 other 2.04
space
plasma
Ret proto-oncogene RET kinase 2.04
membrane
plasma
Fibroblast growth factor receptor 1 FGFR1 kinase 2.04
membrane
Integrin, alpha 2 (CD49B, alpha 2 subunit of plasma transmembrane
ITGA2 2.02
VLA-2 receptor) membrane receptor
Eukaryotic translation initiation factor 2-
EIF2AK2 cytoplasm kinase 1.94
alpha kinase 2
Unc-51 like autophagy activating kinase 1 ULK1 cytoplasm kinase 1.83
extracellular
Vascular endothelial growth factor A VEGFA group 1.75
space
GENES DOWNREGULATED
log2 fold
Name Gene Symbol Location Type(s)
change
Protein tyrosine phosphatase, non-receptor
PTPN22 cytoplasm phosphatase -11.55
type 22
ADAM metallopeptidase with extracellular
ADAMTS9 peptidase -11.21
thrombospondin type 1 motif, 9 space
Prickle homolog 2 PRICKLE2 nucleus other -11.08
Neurotrophic tyrosine kinase, receptor, type plasma
NTRK3 kinase -8.13
3 membrane
Contactin associated protein-like 3B CNTNAP3B unknown other -7.29
extracellular
WNT inhibitory factor 1 WIF1 other -4.75
space
Keratin, Type I cytoskeletal 20 CK20 (KRT20) cytoplasm other -4.22
Deiodinase, iodothyronine, type II DIO2 cytoplasm enzyme -3.62
transcription
Zinc finger protein 217 ZNF217 nucleus -3.41
regulator
plasma
Ca++-dependent secretion activator CADPS other -3.15
membrane
Table 1: Identification of significantly upregulated and downregulated genes by ACSL4 overexpression using RNA-
Seq.