POPULATION GENETICS

5. (10pts) The following are the observed ABO blood group phenotypes
among a group of 600 Canadian Indians: Type O = 288, Type A = 280, Type
B = 19, Type AB = 13. Calculate the gene and allele frequencies.

6. (10pts) Which of the following genotype frequencies of AA, Aa and aa,

respectively, satisfy the
Hardy-Weinberg principle? Show all your calculations.
e) 0.25, 0.50, 0.25
f) 0.36, 0.55, 0.09

EXTRACHROMOSOMAL INHERITANCE
2. (15pts) In barley, a self-fertilizing species that can be cross-fertilized,
two true-breeding strains with virescent leaves occur. In strain A, the trait
is caused by a cytoplasmic gene while in strain B, it is by a recessive
chromosomal gene. What phenotypes would you expect among the
progeny, and in what proportions in reciprocal crosses between A and B?

4. (15pts) In corn, male sterility is controlled by maternal cytoplasmic

elements. This phenotype renders the male part of corn plants (tassel)
unable to produce fertile pollen; the female parts, however, remain
receptive to pollination by pollen from male fertile corn plants. However,
the presence of a nuclear fertility restorer gene F restores fertility to male
sterile lines.
What are the phenotypes and genotypes of the offsprings in the following
crosses?

a. Male sterile female x Ff male

b. Selfing of (a) to produce F2
QUANTITATIVE
1. (10pts) In sorghum, many widely diverse types of plants exist. In the
milotypes sorghum, 4 recessive genes for short stature have been
identified. They have been designated dw1, dw2, dw3, and dw4. The
effect of these dwarfing genes is to shorten the internode length. A plant
homozygous recessive for these 4 pairs of dwarfing genes is 16 inches tall.
A plant homozygous dominant for these 4 pairs of genes is 96 inches tall.
Assume these alleles contribute quantitatively, cumulative and equally
for this height difference.

A plant of genotype Dw1Dw1Dw2Dw2Dw3Dw3dw4dw4 was crossed to

one of genotype dw1dw1dw2dw2dw3dw3Dw4Dw4. F1 and F2
generations were observed.
a) What would be the heights of the F1?
b) Show the range of heights expected in the F2 progeny.
3. (10pts) Two inbred strains of corn were crossed to produce an F1,
which was then intercrossed to produce an F2. Data on ear length from a
sample of F1 and F2 individuals gave phenotypic variances of 15.2cm2 and
27.6cm2, respectively. Why was the phenotypic variance greater for the
F2 than for the F1?
Human Genetics
1. (15pts) Below is the pedigree of dwarfism in 5 generations of a family
(Red = affected). What is the mode of inheritance of dwarfism? How do
you explain the appearance of dwarfism in the 2nd generation when it is
not found in the 1st generation?

2. (10pts) The pedigree below shows the inheritance of a recessive trait

(Red = affected). What is
the chance that the couple III-3 and III-4 will have an affected child?

BONUS: (5pts) You want to introduce the human insulin gene into a bacterial host in hopes of
producing
a large amount of human insulin. Should you use the genomic DNA or the cDNA? Explain your
reasoning.