Protein

By El Wathan
Organic Chemistry for third grade
Out Line

Classificatio
Definition Structures Bonds
1 2 3 ns 4

Functions Sources Analysis

5 6 7
 Definition

#aminoacid #Peptidebond #peptides

#polypeptides
Definition

are macromolecules
that consist of one or
Proteins
more polypeptide
chains
Definition

are polymer chain of

amino acid as
Polypeptide
monomer linked by
peptide bonds
Definition

are bi-functional
compounds that
Amino Acid contain amine and
carboxylic acid which
are attached to α
carbon
Definition

are a covalent bond in

amide functional
Peptide Bond group that are formed
from reaction between
two amino acids
 Structures

#primary #secondary #tertiary

#quarternary #folding
Structures
Structures

m a r y
P ri
Linear structure of protein and there is no interaction
beside peptide bond between amino acid
Protein
Structures
2 regular
folding
patterns have
been
identified –
formed
between the
bonds of the
peptide
backbone

ond a r y Regular folding of polypeptide chain as a result of

Sec hydrogen interaction between every amino acid
Protein
Structures
2 regular
folding
patterns have
been
identified –
formed
between the
bonds of the
peptide
backbone

ond a r y Regular folding of polypeptide chain as a result of

Sec hydrogen interaction between every amino acid
Protein
Structures
2 regular
folding
patterns have
been
identified –
formed
between the
bonds of the
peptide
backbone

ond a r y Regular folding of polypeptide chain as a result of

Sec hydrogen interaction between every amino acid
Protein
Structures
2 regular
folding
patterns have
been
identified –
formed
between the
bonds of the
peptide
backbone

ond a r y Regular folding of polypeptide chain as a result of

Sec hydrogen interaction between every amino acid
Protein
Structures Core of many proteins is
the -sheet
Form rigid structures
with the Hydrogen bond
Can be of 2 types :
-sheet Anti-parallel – run in an
opposite direction of its
neighbor (A)

Parallel – run in the same

direction with longer

ond a r y looping sections between

Sec them (B)

Protein
Structures Formed by a Hydrogen
bond between every 4th
peptide bond – C=O to N-H

Usually in proteins that

span a membrane

α-helix
The helix can either coil to
the right or the left

Can also coil around each

ond a r y other – coiled-coil shape –
Sec a framework for structural

Protein
proteins such as nails and
skin
Structures

r ti ra y Irregular folding of one polypeptide chain as a result

Te of many interactions between side group in every
Protein different amino acid
Structures

r ti ra y Irregular folding of one polypeptide chain as a result

Te of many interactions between side group in every
Protein different amino acid
Structures

ter na r y
Qua r Irregular folding of two or more polypeptide chains
as a result of many interactions between side
Protein group in every different amino acid
Structures
 Bonds

#peptidebond #hydrogenbond #saltbridge

#disulfidebridge #vanderwaalsinteraction
#hydrophobicinteraction
Bonds Peptide Bond
Bonds Peptide Bond
Bonds Hydrogen Bond
Bonds Salt Bridge
Bonds Disulfide Bridge
Bonds Disulfide Bridge
Bonds Van Der Waals Interaction
Bonds Hydrophobic Interaction
Bonds
Classifications

#globular #fibrouos #simple

#conjugated #derived
Classification
base on Shape

Fibrous
Classification Example
base on Shape Elastin

Fibrous
Classification Stabilizing Cross-Links
Example
base on Shape • Cross linkages can be between 2 parts of a Elastin
protein or between 2 subunits

Fibrous • Disulfide bonds (S-S) form between adjacent

-SH groups on the amino acid cysteine
Classification Example
base on Shape Keratin

Fibrous
Classification
base on Shape

G lobular
Classification Example
base on Shape Hemoglob

G lobular
Classification Example
base on Shape Globulin

G lobular
Classification
base on Composition

S imple
Classification Example
base on Composition Histone

S imple
Classification
base on Composition

Conjugated
Classification
base on Composition

Conjugated
Lipoprotein
Protein that
has LIPIDS
as
prosthetic
group
Ex. Peripheral
apoprotein
Classification
base on Composition

Conjugated

Glycoprotein
Protein that has
CARBOHYDRATE
as prosthetic group
Ex. Some membrane
Classification
base on Composition

Conjugated
Nucleoprotein
Protein that has
DNA/RNA as
prosthetic
group
Ex. Nucleosome
Classification
base on Composition

Conjugated
Metaloprotei
Proteinn that
has METAL
as
prosthetic
group
Ex. Hemoglobin
Classification
base on Composition

Conjugated
Chromoprotein
Protein that has
CHROMOPHORE
group as
prosthetic group
Ex. Myoglobin
Classification
base on Composition

Derived
 Functions

#structural #functional #enzyme

#hormone #transport #storage
FunctionsStructural
One of the important function of protein is structural,
ex. Collagen (A) and Elastin (B)
FunctionsFunctional

Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional
Ligan Binding
Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional
Ligan Binding
Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional

Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional

Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional

Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional

Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional

Enzymes
Hormones
Antibodies
Storages
Transport
FunctionsFunctional Example is
Hemoglobin
can transport
Enzymes Oxygen
Hormones
Antibodies
Storages
Transport
Protein can
be used to
transport a
specific
molecule
inside the
body.
Sources

#eggs #soy #milk

Sources

Casein

Milk
Sources

Soy Protein

soy
Sources

Albumin

Egg
 Analysis

#qualitative #quantitative #biurettest

#electrophoresis #kjeldahlmethod #nitrogencontain
Analysis

Qualitative
Analysis
Analysis

Quantitative
Analysis
Thank you

El Wathan