Professional Documents
Culture Documents
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3. Vessel Wall 25
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Platelet Plug Fibrin Clot
Formation Formation
Antithrombotic
Fibrinolytic System
Mechanism
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Platelet Plug Formation
On vascular injury, platelets adhere to the site of injury,
usually covering the vascular intimal surface.
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Inherited? Acquired?
Determine: NSAID » precipitate GI bleeding
Easy bruising? Menorrhagia?
- the bleeding or thrombosis
Epistaxis? (Not specific)
site Effect of other NSAIDs is shorter,
Post partum haemorrhage?
- is it enhanced by medical as the inhibitor effect is reversed
Prolonged bleeding in/post surgery?
condition/medication/dietary when the drug is removed
supplement?
UNDERLYING SYSTEMIC
HISTORY OF
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DISEASES THAT CAUSE OR
EXACERBATE A BLEEDING
TENDENCY THROMBOSIS
• Screening assays
• Mixing studies
• Specific factor assays
• Testing for Antiphospholipid antibodies
• Other coagulation test
• Laboratory testing for thrombophilia
• Measures of platelet function
Hemostatic Abnormalities
And what to expect?
Thank you