Abstract

Background : Sepsis is a life-threatening organ dysfunction. Clinical symptoms and signs are
found can be used as an assessment of the stages and prognosis of sepsis, in addition, the
prognosis of sepsis may also be assessed through biomarkers. Biomarkers that are often used as
prognostic include C-reactive protein (CRP) and procalcitonin (PCT). In sepsis there is an
increasing use of cholesterol resulting in hypocholesterolemia This study aims to determine the
correlation of total cholesterol and CRP in sepsis patients at RSUP Dr Mohammad Hoesin
Palembang.

Method: This case study was conducted in the Department of Surgery of RSMH Palembang
RSUP Dr Mohammad Hoesin Palembang from November to December 2107. Obtained 30
patients with sepsis patients who met the inclusion criteria. The frequency and distribution of
data are described in tabular form. The correlation between total cholesterol and CRP was
analyzed using Spearman Rho's test. The association of cholesterol and CRP with mortality was
analyzed using Chi Square test. Data analysis using SPSS version 18.0.

Result: From 30 samples of sepsis patients, the mean age was 44.33 ± 16,308 years old with the
age range of 16 to 77 years. The majority of sexes in this study were males in which male and
female ratio of 2: 1 with the most occupation was private (33.3%) and housewife (30%). In this
study we found the mean cholesterol of 1st day sepsis patient was 131,71 ± 32,16 mg / dl and
increased at 3rd day equal to 148,13 ± 51,04 mg / dl while mean CRP of sepsis patient equal to
119,8 ± 100.09 ng / L and decreased on 3 rd day by 99.3 ± 79.07 ng / L. The correlation test
showed a significant mean negative correlation between cholesterol and 1 st day CRP in sepsis
patients (r = - 0.456; p = 0.011; n = 30) and the negative correlation was not significantly
significant between cholesterol and 3rd day CRP in sepsis patients (r = - 0.065; p = 0.733; n =
30). In addition, there was no significant association between 1st day cholesterol and mortality in
sepsis patients (PR = 1,154; p = 1,000; p> 0.05) and a non-significant relationship between 1 st
day CRP and death in septic patients (PR = 1,333; p = 1,000; p> 0,05).

Conclusion: It can be concluded that there is no significant negative correlation between

cholesterol and CRP levels in sepsis patients at Dr Mohammad Hoesin Hospital Palembang.

Keywords: C Reactive Protein, Death, Cholesterol, Correlation, Sepsis.