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  • Pathway

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    pathway

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    © All Rights Reserved
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    21 views1 page

    Pathway

    Uploaded by

    dimas galuh
    pathway

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Diabetes

    Diacylglycerol (DAG) Oxidative stress


    Advanced glycosylation
    generation
    end products (AGE)

    PKC β activation

    Ruboxistaurin

    ↑VEGF/VPF
    Microvascular damage
    ↑TGF β

    ↑eNOS
    ↓ET-1A11 Nephopathy

    Macular Edema Neovascularization


    Renal falure
    Neuropathy
    Vision loss

    Ulcers, Amputation

    Sumber : www.medscape.com

    PKC Protein Kinase C


    VEGF/VPF Vascular Endothelial Growth Factor/Vascular
    Permeability Factor
    TGF Transforming Growth Factor
    eNOS Endhothelial Nitric Oxide Synthase
    ET-1A11 Endothelin

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