Professional Documents
Culture Documents
What?
• Esthesioneuroblastoma (ENB)
• Olfactory neuroblastoma (ONB)
http://www.theantiseptic.in/uploads/medicine/
Olfactory%20Neuroblastoma%20-
%20A%20Rare%20Sinonasal%20Malignancy.jpg
•Neuroectodermal Tumors
• Small, blue round cells
• Group I: With epithelial differentiation, i.e. sinonasal undifferentiated carcinoma
• Group II: Without epithelial differentiation, i .e. olfactory neuroblastoma
http://histonano.com/books/Junqueira%27s%2
https://www.semanticscholar.org/paper/HEAD-AND-NECK-PRE-
0Basic%20Histology%20PDF%20WHOLE%20BO MEETING-OF-THE-22-N-D-EUROPEAN-OF-
OK/17.%20The%20Respiratory%20System.htm Thompson/552e82d429b20c47a6733a0053f2c658360c159a/figure/8
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https://www.istockphoto.com/photos/stacked-
files?sort=mostpopular&mediatype=photograp
hy&phrase=stacked%20files
Diagnostic Workup
•Clinical Exam
• Revealed a “polypoid lesion medial to the right turbinate”
•Ultrasound
• Lymph nodes evaluated- found three nodules in the right neck, largest at 3 cm
•Biopsy
• Fine needle aspiration (FNA) of right lymph node was positive for neuroendocrine
carcinoma
• Diagnostic endoscopic sinus surgery (ESS) performed- showed a large sinonasal tumor
on the right side that was ”destructive in nature and vascular in appearance”
• Ruled out undifferentiated sinonasal carcinoma, and confirmed a high grade olfactory
neuroblastoma
•M RI & CT
• Revealed a large “bilobed mass” centered on the cribriform plate, extension into
inferior right frontal lobe and sinonasal cavity, and also extensive nodal disease
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• Stage A: • Grade I:
• Tumor is confined to the nasal cavity • No mitotic figures
• Stage B: • Grade II:
• Tumor is confined to the nasal cavity and paranasal sinuses Kadish Stage D • Some mitotic figures Hyams Grade III-IV
• Stage C: • Grade III:
• Tumor extends beyond the nasal cavity and paranasal sinuses • Prominent mitotic figures
• Stage D: • Grade IV:
• Regional lymph node or distant metastasis • Marked mitotic figures
https://www.alamy.com/stock-photo/endoscopic.html
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https://www.amazon.com/60pcs-Untreated-Unflavored-Disposable-Sponge/dp/B01E5A4W9A
http://www.karibuadventure.com/oxygen/
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